Continuous Glucose Monitoring System Profile of Women Stratified Using Different Levels of Glycated Hemoglobin (HbA1c) in Early Pregnancy: A Cross-sectional Study

Gupta, Yashdeep; Singh, Charandeep; Goyal, Alpesh; Kalaivani, Mani; Bhatla, Neerja; Tandon, Nikhil

doi:10.1007/s12325-022-02405-w

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HbA1c levels as a key indicator of glucose control are associated with better T2DM management and reduced complications risk 37 . Generally, elevated HbA1c indicates persistent hyperglycemia, fostering NAFLD development, 38 hepatic lipid accumulation, hepatic steatosis, and triggering inflammation, leading to liver cirrhosis. Findings of our study provide valuable insights into the relationship between HbA1c levels and the risks of NAFLD and liver cirrhosis in individuals with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus

Han,

Zhang,

Liu

et al. 2024

Journal of Diabetes

View full text Add to dashboard Cite

BackgroundNonalcoholic fatty liver disease (NAFLD) and liver cirrhosis are significant clinical concerns, especially among individuals with type 2 diabetes mellitus (T2DM). However, in China, there is a paucity of reliable evidence detailing the characteristics of NAFLD and liver cirrhosis in T2DM. Furthermore, the relationship between blood glucose levels and NAFLD prevalence remains unclear.MethodsData from the Shanghai Suburban Adult Cohort and Biobank were analyzed, including 6621 participants with T2DM. NAFLD was diagnosed by ultrasonography and liver cirrhosis was performed according to the health information systems. Logistic regression and restricted cubic spline analysis were used to explore the potential risk factors for NAFLD and liver cirrhosis.ResultsThe prevalence of NAFLD was 59.36%, and liver cirrhosis was 1.43% among T2DM patients. In these patients, factors like age, being female, marital status, and obesity significantly increased the risk of NAFLD. Specifically, obesity had a strong positive association with NAFLD (odds ratio [OR] = 4.70, 95% confidence interval [CI]: 4.13–5.34). The higher glycated hemoglobin (HbA1c) quartile was associated with a heightened NAFLD risk compared to the lowest quartile (all p < .001). The HbA1c‐NAFLD relationship displayed a linear that mimicked an inverted L‐shaped pattern. A significant positive association existed between HbA1c levels and NAFLD for HbA1c <8.00% (OR = 1.59, 95% CI: 1.44–1.75), but this was not observed for HbA1c >8.00% (OR = 1.03, 95% CI: 0.92–1.15).ConclusionSystematic screening for NAFLD is essential in T2DM patients, especially with poor glucose control and obesity in female.image

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus

Han,

Zhang,

Liu

et al. 2024

Journal of Diabetes

View full text Add to dashboard Cite

show abstract

Biometrics of complete human pregnancy recorded by wearable devices

Keeler Bruce,

González,

Dasgupta

et al. 2024

npj Digit. Med.

View full text Add to dashboard Cite

In the United States, normal-risk pregnancies are monitored with the recommended average of 14 prenatal visits. Check-ins every few weeks are the standard of care. This low time resolution and reliance on subjective feedback instead of direct physiological measurement, could be augmented by remote monitoring. To date, continuous physiological measurements have not been characterized across all of pregnancy, so there is little basis of comparison to support the development of the specific monitoring capabilities. Wearables have been shown to enable the detection and prediction of acute illness, often faster than subjective symptom reporting. Wearables have also been used for years to monitor chronic conditions, such as continuous glucose monitors. Here we perform a retrospective analysis on multimodal wearable device data (Oura Ring) generated across pregnancy within 120 individuals. These data reveal clear trajectories of pregnancy from cycling to conception through postpartum recovery. We assessed individuals in whom pregnancy did not progress past the first trimester, and found associated deviations, corroborating that continuous monitoring adds new information that could support decision-making even in the early stages of pregnancy. By contrast, we did not find significant deviations between full-term pregnancies of people younger than 35 and of people with “advanced maternal age”, suggesting that analysis of continuous data within individuals can augment risk assessment beyond standard population comparisons. Our findings demonstrate that low-cost, high-resolution monitoring at all stages of pregnancy in real-world settings is feasible and that many studies into specific demographics, risks, etc., could be carried out using this newer technology.

show abstract

Continuous Glucose Monitoring System Profile of Women Stratified Using Different Levels of Glycated Hemoglobin (HbA1c) in Early Pregnancy: A Cross-sectional Study

Cited by 2 publications

References 25 publications

Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus

Prevalence of nonalcoholic fatty liver disease and liver cirrhosis in Chinese adults with type 2 diabetes mellitus

Biometrics of complete human pregnancy recorded by wearable devices

Contact Info

Product

Resources

About