Continuous Glucose Monitoring System in the Screening of Early Glucose Derangements in Children and Adolescents with Cystic Fibrosis

Franzese, Adriana; Valerio, Giuliana; Buono, Pietro; Spagnuolo, Maria Immacolata; Sepe, Angela; Mozzillo, Enza; Simone, Ilaria De; Raia, Valeria

doi:10.1515/jpem.2008.21.2.109

Cited by 47 publications

(41 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have shown a weak correlation between HbA1c and the degree of glucose tolerance. However, when HbA1c yields a high result, it should be taken into consideration in the diagnosis (20,21).…”

Section: Definition and Diagnosis Of Cfrd -An Evolving Visionmentioning

confidence: 99%

Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)

Noronha

Calliari

Damaceno

et al. 2011

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Cystic fibrosis (CF) is the most common recessive autosomal disease among Caucasian. Children with CF have benefitted from advances in medical and nutritional treatments, and this can be gleaned from the improvement in the survival of these patients. The increase in the survival rate brought with it the appearance of co-morbidities related to CF. Nowadays cystic fibrosis-related diabetes (CFRD) is considered the most common complication associated with CF. It can appear as early as infancy or adolescence, and its prevalence can be as high as 50% in adult patients. Because of its high prevalence, difficulties in early detection and the risks involved, in recent years several studies and consensuses have focused on this condition, adding information about the epidemiology, pathophysiology, prognosis and treatment of CFRD. The main aspects of these new concepts, as well as the current recommendations for its diagnosis and follow-up, will be presented in this study.

show abstract

Section: Definition and Diagnosis Of Cfrd -An Evolving Visionmentioning

confidence: 99%

Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)

Noronha

Calliari

Damaceno

et al. 2011

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Franzese et al 194 also examined the use of CGMSs, this time in further investigation of PPH. Eighty-seven patients aged > 10 years had OGTTs, and 27 had at least one abnormal intermediate (30,60 or 90 minutes, but details not given) level of > 7.6 mmol/l.…”

mentioning

confidence: 99%

Screening for cystic fibrosis-related diabetes: a systematic review.

Waugh

Royle²,

Craigie³

et al. 2012

Health Technol Assess

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

show abstract

“…Moreover, in selected high-risk adolescents with CF and NGT or IGT, pathological CGMS glucose excursions were reported in around 50-70% of the cases (10,12).…”

Section: Discussionmentioning

confidence: 99%

“…There is now evidence that the OGTT method, evaluating fasting and 2-h postload glucose, may miss episodes of hyperglycaemia. It has been demonstrated recently that the continuous glucose monitoring system (CGMS) is a useful and valid tool in defining glucose metabolism in children and adults affected by CF with early glucose derangements (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Abnormal glucose tolerance in children with cystic fibrosis: the predictive role of continuous glucose monitoring system

Schiaffini

Baratto

Russo

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

A long pre-diabetic phase of abnormal glucose tolerance is described in subjects with cystic fibrosis (CF) since childhood. Objective: The aims of the study were to compare oral glucose tolerance test (OGTT) and continuous glucose monitoring system (CGMS) in the diagnosis of altered glucose metabolism, and to longitudinally evaluate the role of CGMS in predicting glucose metabolism deterioration in children with CF. Methods: Seventeen children with CF and 14 controls were enrolled (mean age 13.3G3.0 years). All subjects underwent OGTT and CGMS registration. On the basis of OGTT, children were classified as normal glucose tolerance, impaired glucose tolerance (IGT), IGT plus at least one glucose value above 200 mg/dl at intermediate OGTT points (IGTC200) and CF-related diabetes (CFRD). HbA1c, glucose area under the curve, insulin sensitivity, and insulinogenic and disposition indexes were also considered. Subjects with CF underwent another OGTT after 2.5 years. Results: Baseline OGTT revealed 3/17 (7.6%) children with CF with at least one glucose value above 200 mg/dl (1 CFRD and 2 IGTC200), while CGMS revealed 6/17 (35.3%) children with glucose excursions above 200 mg/dl (PZ0.010). None of the controls showed glucose over 200 mg/dl either at OGTT or at CGMS. At the 2.5-year follow-up OGTT, all the six subjects who had diabetic glucose excursion (i.e. O200 mg/dl) at baseline CGMS presented IGTC200 or CFRD. In logistic regression analysis, CGMS diabetic excursion was the strongest predictor of IGTC200 and CFRD (P!0.001). Conclusions: CGMS could be a useful tool to predict glucose metabolism derangements in children affected by CF.

show abstract

Continuous Glucose Monitoring System in the Screening of Early Glucose Derangements in Children and Adolescents with Cystic Fibrosis

Abstract: Intermediate glucose values during OGTT should be considered as a screening test in patients with CF. CGMS can be useful in studying the early occurrence of glucose derangements in selected patients.

Cited by 47 publications

References 20 publications

Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)

Update on diagnosis and monitoring of cystic fibrosis-related diabetes mellitus (CFRD)

Screening for cystic fibrosis-related diabetes: a systematic review.

Abnormal glucose tolerance in children with cystic fibrosis: the predictive role of continuous glucose monitoring system

Contact Info

Product

Resources

About