Continuous Glucose Monitoring in Newborn Babies at Risk of Hypoglycemia

Harris, Deborah L; Battin, Malcolm; Weston, Philip J.; Harding, Jane E.

doi:10.1016/j.jpeds.2010.02.003

Cited by 135 publications

(118 citation statements)

References 19 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…22 The monitor remained in place for at least 48 hours or up to seven days until there was no longer clinical concern about hypoglycemia. These monitors have been shown to be safe and reliable in newborn babies, including at low glucose concentrations.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study): a randomised, double-blind, placebo-controlled trial

et al. 2013

View full text Add to dashboard Cite

BackgroundNeonatal hypoglycemia is common and a preventable cause of brain damage.Dextrose gel is used to reverse hypoglycemia in diabetics. However, there is little evidence for its use in babies. MethodWe enrolled 514 babies 35 to 42 weeks' gestation, < 48 hours, and at risk of hypoglycemia, to a randomized, double-blind placebo controlled trial to determine whether 40% dextrose gel massaged into the buccal mucosa is more effective than feeding alone in reversing hypoglycemia. Hypoglycemic babies were randomized to 40% dextrose gel 200 mg/kg (n= 118) or placebo (n= 119) and encouraged to feed.Primary outcome was treatment failure (blood glucose concentration <2·6 mmol/L) after two treatment attempts. FindingsDextrose gel reduced the frequency of treatment failure (16/118 (14%) in dextrose vs. 29/119 (24%) in placebo group, RR 0·57; 95% CI 0·33 to 0·98; p=0·04). Babies receiving dextrose gel were less likely to be admitted to intensive care for hypoglycemia, (16/118 (14%) vs. 30/119 (25%); RR 0.54 (0.31, 0.93); P=0.03), to receive formula feeds (median 7 vs. 10 feeds; median difference 2; 95% CI 0 to 4; p=0·04) and to be formula fed at two weeks (5/118 (4%) vs.15/119 (13%), RR 0·34; 95% CI 0·13 to 0·90; p=0·03). 3 InterpretationDextrose gel should be considered for first-line treatment for management of hypoglycemia in late preterm and term babies in the first 48 hours after birth.

show abstract

Section: Resultsmentioning

confidence: 99%

“…These monitors have been shown to be safe and reliable in newborn babies, including at low glucose concentrations. 22,23 Interstitial glucose concentrations cannot be viewed in real time, ensuring clinical practice was not influenced by the results.…”

Section: Resultsmentioning

confidence: 99%

Dextrose gel for neonatal hypoglycaemia (the Sugar Babies Study): a randomised, double-blind, placebo-controlled trial

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Insulin dose was increased based on the result of the glucose curve with the portable device. Insulin dosage unit for regular (R-) insulin and neutral protamine Hagedorn (NPH) is IU/kg and blood glucose unit is mmol/l doi: 10.17221/25/2017-VETMED caemia monitoring, but also in human paediatrics; it could detect 215 out of 265 episodes (81%) of infant hypoglycaemia, which were not verified with blood glucose measurements (Harris et al 2010). Furthermore, the CGMS showed a reasonable accuracy and allowed clinicians to identify and prevent hypoglycaemia, so that BG levels were well-controlled in children with septic shock (Prabhudesai et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Comparison of continuous and intermittent glucose monitoring systems in a dog with diabetic ketoacidosis: a case report

Kim¹,

Kim²,

Kang³

et al. 2017

Vet. Med. - Czech

View full text Add to dashboard Cite

ABSTRACT:A Miniature schnauzer (12 years old, neutered male) was referred for lethargy, anorexia, and oral bleeding. On initial evaluation, severe hyperglycaemia (blood glucose concentration of 34.9 mmol/l), ketonuria, systemic inflammation (fever, panting, left-shift neutrophilia, and a high C-reactive protein level of 980.97 nmol/l, abnormal pancreatic lipase immunoreactivity, and periodontitis were found. With consideration of possible insulin resistance, blood glucose (BG) levels were monitored using a portable glucose meter (q 1-3 h) and a continuous glucose monitoring system (CGMS) for 72 h (three consecutive trials); intensive insulin therapy was initiated using regular insulin (2.2 IU/kg intravenously). The insulin doses needed, based on the nadir, peak, and duration of insulin action from a traditional intermittent glucose curve were higher than those based on the CGMS results. Meanwhile, transient hyperglycaemic and hypoglycaemic periods, occurring between the intermittent measurements, were easily identified with the CGMS. Therefore, insulin resistance and the Somogyi phenomenon are less likely to occur with use of the CGMS than with intermittent BG measurements. By comparing data from a CGMS to those from an intermittent portable BG measurement system, this case report emphasises the importance and usefulness of a CGMS.

show abstract

“…40 In 2013 Beardsall et al performed a multicenter randomized controlled trial that validated the use of Medtronic CGM from 188 very low birth weight premature infants (<1000 g). The CGM data correlated well with point of care devices, with minimal bias and accuracy that did not deteriorate over a 7-day period.…”

Section: Cgm In Pediatrics Clinical Use S-39mentioning

confidence: 99%