Continuous flow synthesis of the ionizable lipid ALC-0315

Wolf, Jakob B.; Lee, Ju Weon; Plutschack, Matthew B.; Cambié, Dario; Seidel-Morgenstern, Andreas; Seeberger, Peter H.

doi:10.1039/d3re00630a

React. Chem. Eng.

2024

DOI: 10.1039/d3re00630a

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Continuous flow synthesis of the ionizable lipid ALC-0315

Jakob B. Wolf,

Ju Weon Lee,

Matthew B. Plutschack

et al.

Abstract: The ionizable lipid ALC-0315 is the major component of the lipid nanoparticles used to encapsulate the mRNA in the Biontech-Pfizer COVID-19 vaccine. In early 2021, difficulties encountered in scaling up...

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Fatty aldehyde bisulfite adducts as a purification handle in ionizable lipid synthesis

Atwood,

Purbiya,

Reid

et al. 2024

RSC Adv.

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Fatty aldehyde bisulfite adducts as a purification handle in ionizable lipid synthesis

Atwood,

Purbiya,

Reid

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

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Continuous flow synthesis of the ionizable lipid ALC-0315

Abstract: The ionizable lipid ALC-0315 is the major component of the lipid nanoparticles used to encapsulate the mRNA in the Biontech-Pfizer COVID-19 vaccine. In early 2021, difficulties encountered in scaling up...

Cited by 1 publication

References 43 publications

Fatty aldehyde bisulfite adducts as a purification handle in ionizable lipid synthesis

Fatty aldehyde bisulfite adducts as a purification handle in ionizable lipid synthesis

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