Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

Azevedo, Lais S. D.; Aguillón, Anderson R.; Lima, Marcelo T.; Leão, Raquel A. C.; Souza, Rodrigo O. M. A. de

doi:10.1007/s41981-021-00189-8

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Active Pharmaceutical Ingredients1

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2023

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“…Most of the literature covering 2020-2022 deal with the preparation of key building blocks (Al-Shameri et al, 2020;Böhmer et al, 2020;Hegarty and Paradisi, 2020;Roura Padrosa et al, 2020;Oeggl et al, 2021;Semproli et al, 2020;Teepakorn et al, 2021;Azevedo et al, 2022;Peng et al, 2022) for fine chemicals/APIs (2020)(2021)(2022). Frontiers in Catalysis frontiersin.org rather than with the total synthesis of drugs (Rinaldi et al, 2020;Wu et al, 2020;Kazan et al, 2021;Romero-Fernandez and Paradisi, 2021;Benítez-Mateos et al, 2022a;Benítez-Mateos and Paradisi, 2022).…”

Section: Active Pharmaceutical Ingredientsmentioning

confidence: 99%

What’s new in flow biocatalysis? A snapshot of 2020–2022

et al. 2023

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Flow biocatalysis is a key enabling technology that is increasingly being applied to a wide array of reactions with the aim of achieving process intensification, better control of biotransformations, and minimization of waste stream. In this mini-review, selected applications of flow biocatalysis to the preparation of food ingredients, APIs and fat- and oil-derived commodity chemicals, covering the period 2020-2022, are described.

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