Continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles via consecutive β-azidation of α,β-unsaturated carbonyl compounds and CuAAC reactions

Abstract

We herein report a multi-step flow protocol for the synthesis of 1,4-disobstitued 1,2,3-triazoles starting from α,β-unsaturated carbonyls. Best results both in terms of chemical productivity and sustainability were obtained using...

Introducing the use of a recyclable solid electrolyte for waste minimization in electrosynthesis: preparation of 2-aryl-benzoxazoles under flow conditions

“…22 We considered it of general interest to explore the contribution of the solid electrolyte to the overall conductivity. In agreement with our research, 23 we have here also designed and built a customized electrochemical flow reactor to better highlight the utility of using a reusable solid electrolyte to enhance the productivity and scalability of the process. Importantly, the flow electrochemical cell allowed us to also improve the usage of the solid electrolyte in terms of current efficiency and electricity consumption.…”

A waste-minimized approach for the synthesis of iodinated organic borazines

“…In our research, we have always tried to compare different reaction techniques, such as flow chemistry, 32–34 microwave irradiation, 35 ball-milling 36 and green solvents 37–39 using green metrics 40,41 to assess the actual benefit in terms of sustainability.…”

Accessing Borazine Substitution Patterns through Late‐Stage Iodination

“…Our research program is committed to develop modern and efficient synthetic tools for advancing the synthetic methodologies making valuable molecules more accessible [24–26] by combining safer reagents/catalysts [27,28] and technologies [29–31] …”

“…[23] Our research program is committed to develop modern and efficient synthetic tools for advancing the synthetic methodologies making valuable molecules more accessible [24][25][26] by combining safer reagents/ catalysts [27,28] and technologies. [29][30][31] In this work we explore strategies to enhance and generalize the post-functionalization of borazines, aiming to facilitate access to a broader array of structures.…”