Continuous flow strategies for using fluorinated greenhouse gases in fluoroalkylations

Abstract

This review highlights recent advances in continuous flow strategies toward enabling the use of fluorinated greenhouse gases in fluoroalkylations.

Repurposing of F-gases: challenges and opportunities in fluorine chemistry

“…Flow methods are emerging as a powerful approach in this regard. 13 The ultimate aim should be to employ chemical recycling methods using recovered F-gases. In the long-term it will be necessary to consider both life-cycle analysis and technoeconomic analysis of any technologies developed – as is already standard in CO 2 remediation methods.…”

“… 184 A recent review article discusses strategies for using CF 3 H and other fluorinated greenhouse gases in flow. 13 …”

“…12 A further review details the advances made in using fluorinated gases in continuous flow processes. 13 2. Applications of F-gases…”

Tetrahydroxydiboron and Nickel Chloride Cocatalyzed Rapid Radical Cyclization toward Pyrrolizidine and Indolizidine Alkaloids

“…Izidines make up an important class of alkaloids containing fused azabicyclic systems, which are prevalent in many bioactive compounds (Scheme a) . Their diverse biological activities and rich structural modifiability have intrigued many synthetic chemists .…”

Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer

“…Emerging and rapidly expanding photocatalysis has offered enormous opportunities to access fluorinated carbon radicals to realize previously inaccessible chemical spaces in a green and sustainable manner . Among them, a variety of transformations have been developed for the difluoromethylation of alkenes .…”