Continuous-Flow Electrochemistry Promoted Aza-Wacker Cyclizations

Electrochemical Rearrangement of Indoles to Spirooxindoles in Continuous Flow

“…While most of the organic electrosynthesis is conducted with batch reactors, continuous flow electrochemical microreactors facilitate conversion, allow easy scale‐up and automation, and reduce the use of supporting electrolyte because of their unique features such as small interelectrode distance, short residence time and large surface to volume ratio [20–28] . Importantly, continuous flow electrochemical microreactors has been shown to enable reactions that are difficult in batch [29–37] . Despite these advantages, continuous flow electrochemical microreactors are underutilized in electrochemical organic synthesis.…”

“…[20][21][22][23][24][25][26][27][28] Importantly, continuous flow electrochemical microreactors has been shown to enable reactions that are difficult in batch. [29][30][31][32][33][34][35][36][37] Despite these advantages, continuous flow electrochemical microreactors are underutilized in electrochemical organic synthesis. During the preparation of this manuscript, Tong and coworkers reported electrochemical oxidative rearrangement of tetrahydro-β-carbolines employing a zero-gap divided flow cell with solution recycle.…”