Continuous‐flow Chemistry in Catalytic Asymmetric Synthesis

Pyrene‐Based D‐A Molecules as Efficient Heterogeneous Catalysts for Visible‐Light‐Induced Aerobic Organic Transformations

“…Due to the aggravation of global energy crisis and environmental contamination, traditionally rough chemical production modes are obviously contrary to the concept of sustainable development, and “green” and “atom economy” become the main theme and pursuit for modern organic chemistry [1–4] . In the past decades, organic chemists spare no efforts in the development of environmental friendly strategy to take place of traditional synthetic methods, consequently, numerous green methods have been developed [5–11] . Recently, photocatalysis, which adopts abundant solar energy for the actuation of artificial synthesis, has been recognized as technically achievable and environmentally sustainable methodology, and has always been the fiery‐hot research field in modern chemistry [12–16] .…”

“…[1][2][3][4] In the past decades, organic chemists spare no efforts in the development of environmental friendly strategy to take place of traditional synthetic methods, consequently, numerous green methods have been developed. [5][6][7][8][9][10][11] Recently, photocatalysis, which adopts abundant solar energy for the actuation of artificial synthesis, has been recognized as technically achiev-able and environmentally sustainable methodology, and has always been the fiery-hot research field in modern chemistry. [12][13][14][15][16] In spite of the potential application of photocatalysis in chemical industry, most researches on this project are still far from practical utilization, the key scientific issues are the development of highly efficient photocatalysts.…”

Reductive N-Alkylation of Amines with Ketones Using Heterogeneous Polysilane–Palladium Catalysts under Continuous-Flow Conditions

“…Scanning tunneling electron microscopy (STEM) images revealed smaller palladium nanoparticles in the 0.05 mmol/g DMPSi−Pd/AC catalyst compared to those in the 0.1 mmol/g version (Figures S5− S8). On the basis of previous studies indicating that calcium phosphate creates more electron-rich palladium species suitable for hydrogenolysis via oxidative addition, 43 we proposed that it might be beneficial for that pathway. In contrast, for reductive amination involving hydrogenation of imine/iminium intermediates, calcium phosphate appeared to have a minimal impact on catalytic activity.…”

“…Interestingly, DMPSi−Pd/AC exhibited superior activity (green line) compared to that of the AC−CP-supported catalyst, contradicting our earlier observations. 41,43 Furthermore, the Pd loading significantly impacted catalytic activity. DMPSi−Pd/AC with a Pd loading of 0.05 mmol/g afforded a >70% yield of 3a after yield stabilization (purple line).…”