Continuous Electrodeless Dielectrophoretic Separation in a Circular Channel

Zhang, L; Tatar, F.; Turmezei, P.; Bastemeijer, J.; Mollinger, J.R.; Piciu, O.M.; Bossche, A.

doi:10.1088/1742-6596/34/1/087

Cited by 17 publications

(13 citation statements)

References 14 publications

(14 reference statements)

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“…Zhang et al. proposed the original idea of using the dielectrophoretic motion induced in a circular microchannel to separate particles with different dielectrophoretic responses. Specifically, the particles with nDEP response are pushed away from the center while those with pDEP response are pulled toward the center.…”

Section: Curved Microchannelsmentioning

confidence: 99%

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Xuan

2019

Electrophoresis

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Microfluidic devices have been extensively used to achieve precise transport and placement of a variety of particles for numerous applications. A range of force fields have thus far been demonstrated to control the motion of particles in microchannels. Among them, electric field‐driven particle manipulation may be the most popular and versatile technique because of its general applicability and adaptability as well as the ease of operation and integration into lab‐on‐a‐chip systems. This article is aimed to review the recent advances in direct current (DC) (and as well DC‐biased alternating current) electrokinetic manipulation of particles for microfluidic applications. The electric voltages are applied through electrodes that are positioned into the distant channel‐end reservoirs for a concurrent transport of the suspending fluid and manipulation of the suspended particles. The focus of this review is upon the cross‐stream nonlinear electrokinetic motions of particles in the linear electroosmotic flow of fluids, which enable the diverse control of particle transport in microchannels via the wall‐induced electrical lift and/or the insulating structure‐induced dielectrophoretic force.

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Section: Curved Microchannelsmentioning

confidence: 99%

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Xuan

2019

Electrophoresis

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“…Combining microfluidic systems with different readout techniques has produced powerful tools in the emerging area of the on-chip controlled handling and monitoring of biological and synthetic microparticles and nanoparticles, with especially great impact on biotechnology and environmental topics, such as hydrodynamic forces [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20], optical methods [21,22], electric fields and dielectrophoresis [23][24][25][26][27] or acoustic fields , either isolated or combined with other fields.…”

Section: Introductionmentioning

confidence: 99%

Optimizing Polymer Lab-on-Chip Platforms for Ultrasonic Manipulation: Influence of the Substrate

González

Tijero²,

Martin

et al. 2015

Micromachines

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Abstract:The choice of substrate material in a chip that combines ultrasound with microfluidics for handling biological and synthetic microparticles can have a profound effect on the performance of the device. This is due to the high surface-to-volume ratio that exists within such small structures and acquires particular relevance in polymer-based resonators with 3D standing waves. This paper presents three chips developed to perform particle flow-through separation by ultrasound based on a polymeric SU-8 layer containing channelization over three different substrates: Polymethyl methacrylate (PMMA); Pyrex; and a cracked PMMA composite-like structure. Through direct observations of polystyrene microbeads inside the channel, the three checked chips exhibit their potential as disposable continuous concentration devices with different spatial pressure patterns at frequencies of resonance close to 1 Mhz. Chips with Pyrex and cracked PMMA substrates show restrictions on the number of pressure nodes established in the channel associated with the inhibition of 3D modes in the solid structure. The glass-substrate chip presents some advantages associated with lower energy requirements to collect particles. According to the OPEN ACCESSMicromachines 2015, 6 575 results, the use of polymer-based chips with rigid substrates can be advantageous for applications that require short treatment times (clinical tests handling human samples) and low-cost fabrication.

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“…Since then, EDEP has been used for separating particles [30], DNA [42], proteins [43], bacterial, and viral cells [44][45][46][47]. Zhang et al [48] presented the design of a circular EDEP microdevice based on a circular channel. Recently, Barbulovic-Nad et al [49] used oil as an insulating post for creating DEP forces that caused continuous separation of particles based on size in a flowing stream.…”

Section: Introductionmentioning

confidence: 99%

Electrodeless direct current dielectrophoresis using reconfigurable field‐shaping oil barriers

2007

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We demonstrate dielectrophoretic (DEP) potential wells using pairs of insulating oil menisci to shape the DC electric field. These oil menisci are arranged in a configuration similar to the quadrupolar electrodes, typically used in DEP, and are shown to produce similar field gradients. While the one-pair well produces a focusing effect on particles in flow, the two-pair well results in creating spatial traps against crossflows. Uncharged polystyrene particles were used to map the DEP force fields and the experimental observations were compared against the field profiles obtained by numerically solving Maxwell's equations. We demonstrate trapping of a single particle due to negative DEP against a pressuredriven crossflow. This can be easily extended to trap and hold cells and other objects against flow for a longer time. We also show the results of particle trapping experiments performed to observe the effect of adjusting the oil menisci and the gap between two pairs of menisci in a four-menisci configuration on the nature of the DEP well formed at the center. A design parameter, Y, capturing the dimensions of the DEP energy well, is defined and simulations exploring the effects of different geometric features on Y are presented.

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Continuous Electrodeless Dielectrophoretic Separation in a Circular Channel

Cited by 17 publications

References 14 publications

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Optimizing Polymer Lab-on-Chip Platforms for Ultrasonic Manipulation: Influence of the Substrate

Electrodeless direct current dielectrophoresis using reconfigurable field‐shaping oil barriers

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