Continuous EEG in ICU: Not a Luxury After All

Bermeo‐Ovalle, Adriana

doi:10.1177/1535759720973987

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…34 However, various concerns have been raised, such as choice of endpoint, ability to convert to cEEG upon seizure/status epilepticus detection, delayed time to EEG start, and active cEEG monitoring during business hours only, which may explain a lower rate of cEEG intervention. 35,36,37 While evidence emerges about what and in whom constitutes an acceptable “seizure miss rate,” our findings suggest that non-cEEG models of practice can face median false-negative rates as high as missing one in five seizures. Although the 2HELPS2B criteria imply that low-risk EEGs can safely stop running at 1 hour, approximately 3/4 of our recordings were medium or high risk, but median duration of all recordings was only just over 1 hour.…”

Section: Discussionmentioning

confidence: 69%

Residual Seizure Rate of Intermittent Inpatient EEG Compared to a Continuous EEG Model

Xie¹,

Toutant²,

Ng³

2023

Can. J. Neurol. Sci.

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Background: Subclinical seizures are common in hospitalized patients and require electroencephalography (EEG) for detection and intervention. At our institution, continuous EEG (cEEG) is not available, but intermittent EEGs are subject to constant live interpretation. As part of quality improvement (QI), we sought to estimate the residual missed seizure rate at a typical quaternary Canadian health care center without cEEG. Methods: We calculated residual risk percentages using the clinically validated 2HELPS2B score to risk-stratify EEGs before deriving a risk percentage using a MATLAB calculator which modeled the risk decay curve for each recording. We generated a range of estimated residual seizure rates depending on whether a pre-cEEG screening EEG was simulated, EEGs showing seizures were included, or repeat EEGs on the same patient were excluded. Results: Over a 4-month QI period, 499 inpatient EEGs were scored as low (n = 125), medium (n = 123), and high (n = 251) seizure risk according to 2HELPS2B criteria. Median recording duration was 1:00:06 (interquartile range, IQR 30:40–2:21:10). The model with highest residual seizure rate included recordings with confirmed electrographic seizures (median 20.83%, IQR 20.6–26.6%), while the model with lowest residual seizure rate was in seizure-free recordings (median 10.59%, IQR 4%–20.6%). These rates were significantly higher than the benchmark 5% miss-rate threshold set by 2HELPS2B (p<0.0001). Conclusions: We estimate that intermittent inpatient EEG misses 2–4 times more subclinical seizures than the 2HELPS2B-determined acceptable 5% seizure miss-rate threshold for cEEG. Future research is needed to determine the impact of potentially missed seizures on clinical care.

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Section: Discussionmentioning

confidence: 69%

Residual Seizure Rate of Intermittent Inpatient EEG Compared to a Continuous EEG Model

Xie¹,

Toutant²,

Ng³

2023

Can. J. Neurol. Sci.

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“…In line with the few previous studies on this topic, the results of the present analysis suggest that rEEG seems feasible as a neurophysiological biomarker and NCU monitoring option for 12-month survival in adult HE patients [ 21 , 48 ]. Considering the still-limited availability of cEEG in rural regions and developing countries, rEEG is a viable alternative to the gold standard of neurophysiological monitoring in neurocritical care [ 19 ]. A recent international survey showed that only a few ICUs have 24/7 availability of EEG technicians and specialized physicians.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, the availability of cEEG is usually limited to maximum care providers or large specialized hospitals and is not comprehensively accessible, especially in rural areas and developing countries [ 19 ]. In addition, extraordinary medical circumstances, such as the recent SARS-CoV-2 pandemic, can significantly restrict the availability of cEEG at neurocritical care centers [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Repetitive Electroencephalography as Biomarker for the Prediction of Survival in Patients with Post-Hypoxic Encephalopathy

Willems

Rosenow

Knake

et al. 2022

JCM

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Predicting survival in patients with post-hypoxic encephalopathy (HE) after cardiopulmonary resuscitation is a challenging aspect of modern neurocritical care. Here, continuous electroencephalography (cEEG) has been established as the gold standard for neurophysiological outcome prediction. Unfortunately, cEEG is not comprehensively available, especially in rural regions and developing countries. The objective of this monocentric study was to investigate the predictive properties of repetitive EEGs (rEEGs) with respect to 12-month survival based on data for 199 adult patients with HE, using log-rank and multivariate Cox regression analysis (MCRA). A total number of 59 patients (29.6%) received more than one EEG during the first 14 days of acute neurocritical care. These patients were analyzed for the presence of and changes in specific EEG patterns that have been shown to be associated with favorable or poor outcomes in HE. Based on MCRA, an initially normal amplitude with secondary low-voltage EEG remained as the only significant predictor for an unfavorable outcome, whereas all other relevant parameters identified by univariate analysis remained non-significant in the model. In conclusion, rEEG during early neurocritical care may help to assess the prognosis of HE patients if cEEG is not available.

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Continuous EEG in ICU: Not a Luxury After All

Abstract: [Box: see text]

Cited by 2 publications

References 17 publications

Residual Seizure Rate of Intermittent Inpatient EEG Compared to a Continuous EEG Model

Residual Seizure Rate of Intermittent Inpatient EEG Compared to a Continuous EEG Model

Repetitive Electroencephalography as Biomarker for the Prediction of Survival in Patients with Post-Hypoxic Encephalopathy

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