Continuous Dose-Response Association Between Sedentary Time and Risk for Cardiovascular Disease

Pandey, Ambarish; Salahuddin, Usman; Garg, Sushil Kumar; Ayers, Colby; Kulinski, Jacquelyn; Anand, Vidhu; Mayo, Helen; Kumbhani, Dharam J.; Lemos, James A. de; Berry, Jarett D.

doi:10.1001/jamacardio.2016.1567

Cited by 191 publications

(176 citation statements)

References 30 publications

(55 reference statements)

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“…Prolonged sitting time increases cardiometabolic risk and all-cause mortality (54,55). A dose-response analysis suggests a nonlinear relationship between sedentary time and increased cardiovascular risk, with increased risk only at high levels of sedentarity (56). High levels of physical activity (at least 60 minutes per day) appear to compensate for the increased risk of death associated with prolonged sitting time (57).…”

Section: Discussionmentioning

confidence: 99%

menuCH - Swiss Nutrition Survey 2014-2015

Bochud¹,

team²

2017

http://isrctn.com/

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Section: Discussionmentioning

confidence: 99%

menuCH - Swiss Nutrition Survey 2014-2015

Bochud¹,

team²

2017

http://isrctn.com/

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“…Based on the PAF calculations, 16.9% (95% CI 14.0% to 19.6%) of cases of type 2 diabetes were associated with sedentary behaviour. Pandey et al 10 reported an adjusted RR of 1.14 (95% CI 1.09 to 1.19) for the association between CVD and sedentary behaviour. Just under 5% (4.9%, 95% CI 4.2% to 5.5%) of CVD could be attributable to sedentary behaviour.…”

Section: Resultsmentioning

confidence: 99%

“…Just under 5% (4.9%, 95% CI 4.2% to 5.5%) of CVD could be attributable to sedentary behaviour. The adjusted RR for the association between sedentary behaviour and all-cause mortality10 was reanalysed in order to exclude four studies. The studies were inappropriate for the following reasons: their baseline populations were not free of disease27; they reported a per-hour association,28 rather than comparing individuals in the most and least sedentary categories; the definition of prolonged sedentary behaviour was not compatible (≥4 hours instead of ≥6 hours)29; or they reported an inapplicable association (one study reported the association between those who were ‘consistently nonsedentary’ and ‘consistently sedentary’) 30.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the researchers had investigated the association by comparing the most sedentary individuals with the least sedentary, and we preferred studies which had used sedentary time as an exposure. Two studies were appropriate for the outcome of CVD9 10: we chose the more recent meta-analysis by Pandey et al 10 as it had included three additional applicable studies. After examining data from the primary studies, we excluded those that did not meet the exact criteria above and repooled the risk estimate using Review Manager (RevMan V.5.3).…”

Section: Methodsmentioning

confidence: 99%

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Direct healthcare costs of sedentary behaviour in the UK

Heron

O’Neill

McAneney

et al. 2019

J Epidemiol Community Health

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BackgroundGrowing evidence indicates that prolonged sedentary behaviour increases the risk of several chronic health conditions and all-cause mortality. Sedentary behaviour is prevalent among adults in the UK. Quantifying the costs associated with sedentary behaviour is an important step in the development of public health policy.MethodsNational Health Service (NHS) costs associated with prolonged sedentary behaviour (≥6 hours/day) were estimated over a 1-year period in 2016–2017 costs. We calculated a population attributable fraction (PAF) for five health outcomes (type 2 diabetes, cardiovascular disease [CVD], colon cancer, endometrial cancer and lung cancer). Adjustments were made for potential double-counting due to comorbidities. We also calculated the avoidable deaths due to prolonged sedentary behaviour using the PAF for all-cause mortality.ResultsThe total NHS costs attributable to prolonged sedentary behaviour in the UK in 2016–2017 were £0.8 billion, which included expenditure on CVD (£424 million), type 2 diabetes (£281 million), colon cancer (£30 million), lung cancer (£19 million) and endometrial cancer (£7 million). After adjustment for potential double-counting, the estimated total was £0.7 billion. If prolonged sedentary behaviour was eliminated, 69 276 UK deaths might have been avoided in 2016.ConclusionsIn this conservative estimate of direct healthcare costs, prolonged sedentary behaviour causes a considerable burden to the NHS in the UK. This estimate may be used by decision makers when prioritising healthcare resources and investing in preventative public health programmes.

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“…8 It is well known that physical inactivity is related to health impairments, but sedentary behavior has recently emerged as a new independent risk factor for chronic diseases as well as for mortality, regardless of moderate-to-vigorous physical activity. [9][10][11][12][13][14] Examples of sedentary behavior include watching television, sitting, playing video games and using computers. 15 Current studies have been investigating associations of physical activity and sedentary behaviors separately or combined.…”

Section: Introductionmentioning

confidence: 99%

Living near the port area is associated with physical inactivity and sedentary behavior

Sperandio

Arantes²,

Chao

et al. 2017

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: The impact of the port of Santos, Brazil, on the population's health is unknown. We aimed to evaluate the association between living near the port area and physical inactivity and sedentary behavior. DESIGN AND SETTING: Cross-sectional study developed at a university laboratory and a diagnostic clinic. METHODS: 553 healthy adults were selected and their level of physical activity in daily life was assessed using accelerometers. Multiple linear and logistic regressions were performed using physical inactivity and sedentary behavior as the outcomes and living near the port area as the main risk factor, with adjustments for the main confounders. RESULTS: Among all the participants, 15% were resident near the port area. They took 699 steps/day and presented, weekly, 2.4% more sedentary physical activity, 2.0% less time in standing position and 0.9% more time lying down than residents of other regions. Additionally, living near the port area increased the risk of physical inactivity by 2.50 times and the risk of higher amounts of sedentary behavior (≥ 10 hours/day) by 1.32 times. CONCLUSION: Living near the port of Santos is associated with physical inactivity and higher sedentary behavior among adults, regardless of confounders. The reasons for this association should be investigated in longitudinal studies. RESUMO CONTEXTO E OBJETIVOS:O impacto do porto de Santos, no Brasil, sobre a saúde da população é desconhecido. Nosso objetivo foi avaliar a associação entre viver nas proximidades da área portuária e a inatividade física e comportamento sedentário. TIPO DE ESTUDO E LOCAL: Estudo transversal desenvolvido em laboratório universitário e em uma clí-nica de diagnósticos. MÉTODOS: Foram selecionados 553 adultos saudáveis e seu nível de atividade física na vida diária foi avaliado usando acelerômetros. Foi realizada regressão linear múltipla e logística usando a inatividade física e o comportamento sedentário como desfechos e morar perto da área portuária como o fator de risco principal, ajustando para os principais confundidores. RESULTADOS: Entre todos os participantes, 15% residiam na área portuária. Estes deram 699 passos/dia a menos e apresentaram, por semana, 2,4% da atividade física mais sedentária, 2,0% menos tempo em pé e passaram 0,9% mais tempo deitados do que os residentes das demais regiões. Além disso, morar nas proximidades da área portuária aumentou o risco de inatividade física em 2,5 vezes, assim como o risco de maior comportamento sedentário (≥ 10 horas/dia) em 1,32 vezes. CONCLUSÃO: Morar perto do porto de Santos tem associação com a inatividade física, assim como o aumento do comportamento sedentário em adultos, independentemente de fatores de confusão. As razões para tal associação devem ser investigadas em estudos longitudinais.

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Continuous Dose-Response Association Between Sedentary Time and Risk for Cardiovascular Disease

Abstract: The association between sedentary time and the risk for CVD is nonlinear with an increased risk only at very high levels. These findings could have implications for guideline recommendations regarding the risks related to sedentary behavior.

Cited by 191 publications

References 30 publications

menuCH - Swiss Nutrition Survey 2014-2015

menuCH - Swiss Nutrition Survey 2014-2015

Direct healthcare costs of sedentary behaviour in the UK

Living near the port area is associated with physical inactivity and sedentary behavior

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