Continuous dissolution rate determination as a function of the pH of the medium

Turi, Paul; Dauvois, M.; Michaelis, A.

doi:10.1002/jps.2600650604

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…aa) Débitage direction. We distinguish between cordal (1) or centripetal (2). Refits were made in order to know the exact place in the chaîne opératoire and the débitage direction of each flake.…”

Section: Methodsmentioning

confidence: 99%

“…This is because blanks can be obtained by several completely different methods, as exemplified by Levallois points [1], or because the flakes or cores from different methods converge in shape and size and can be difficult to differentiate. Several studies have aimed to morphologically and qualitatively identify some of these methods through the technological, diacritical, and structural readings of blanks and cores [2][3][4], and, more recently, through various methodologies such as typometry, statistics, 3D models, and geometric-morphometric approaches [5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Distinguishing Discoid and Centripetal Levallois methods through machine learning

et al. 2020

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In this paper, we apply Machine Learning (ML) algorithms to study the differences between Discoid and Centripetal Levallois methods. For this purpose, we have used experimentally knapped flint flakes, measuring several parameters that have been analyzed by seven ML algorithms. From these analyses, it has been possible to demonstrate the existence of statistically significant differences between Discoid products and Centripetal Levallois products, thus contributing with new data and a new method to this traditional debate. The new approach enabled differentiating the blanks created by both knapping methods with an accuracy >80% using only ten typometric variables. The most relevant variables were maximum length, width to the 25%, 50% and 75% of the flake length, external and internal platform angles, maximum width and number of dorsal scars. This study also demonstrates the advantages of the application of multivariate ML methods to lithic studies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinguishing Discoid and Centripetal Levallois methods through machine learning

et al. 2020

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Drug Delivery Systems 5A. Oral Drug Delivery

Ranade¹

1991

The Journal of Clinical Pharma

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The two main advantages of controlled drug delivery systems are: maintenance of therapeutically optimum drug concentrations in the plasma through zero-order release without significant fluctuations; and elimination of the need for frequent single dose administrations. The oral and other therapeutic systems in human use have validated the concept that controlled continuous drug release can minimize the daily dose of a drug required to maintain the required therapeutic effect, while minimizing unwanted pharmacological effects. By minimizing patient intervention, a design feature of therapeutic systems, compliance is automatically enhanced. Oral drug delivery systems, in particular, have required innovation in materials science to provide materials biocompatible during prolonged contact with body tissues, bioengineering to develop drug delivery modules, and clinical pharmacology for elucidation of drug action under conditions of continuous controlled drug administration. Recent work in advanced oral delivery has been primarily focused on liposome technology and the concept that substances that are normally destroyed by the stomach can be protected long enough before they could be absorbed downstream. For cost and patient convenience, oral delivery certainly would be an attractive method. The nature of biologic substances, however, with their unique technical problems, will probably limit greatly those that can be delivered orally. Besides, where delivery rate control is critical, oral delivery, even when possible, would probably be insufficiently precise. Oral delivery would also limit the substance to bloodstream delivery to the disease site. Even so, oral controlled drug delivery systems will likely find primary usefulness in specific carefully controlled therapies and prophylactic situations with due regard for drug interactions. This system represents a potentially very significant therapeutic modality. These delivery systems will find usefulness primarily in certain well-defined and well-controllable areas with due regard for individual patient variations. The purpose of the present article is to review oral controlled-release drug delivery systems, with particular emphasis on the practical aspects of testing and fabricating these systems and the underlying mechanisms by which control over drug release rate is accomplished.

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Oral drug delivery

2003

Drug Delivery Systems, Second Edition

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Continuous dissolution rate determination as a function of the pH of the medium

Cited by 3 publications

References 4 publications

Distinguishing Discoid and Centripetal Levallois methods through machine learning

Distinguishing Discoid and Centripetal Levallois methods through machine learning

Drug Delivery Systems 5A. Oral Drug Delivery

Oral drug delivery

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