Continuous delivery of propranolol from liposomes-in-microspheres significantly inhibits infantile hemangioma growth

Guo, Xiaonan; Zhu, Xiaozhong; Liu, Dakan; Gong, Yubin; Sun, Jing; Dong, Chao

doi:10.2147/ijn.s137634

Cited by 24 publications

(12 citation statements)

References 30 publications

(28 reference statements)

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“…In recent years, drug delivery systems, such as liposomes and microspheres, have attracted much attention. Since the membrane of liposomes is soft and easily ruptured, the sustained release of liposomes is not satisfactory, 18 and microspheres were selected as drug delivery system. The microspheres prepared in this study have a higher drug loading efficiency, with encapsulation efficiency fulfilling the requirements of the pharmacopoeia, which proves the reliability of the microsphere preparation process.…”

Section: Discussionmentioning

confidence: 99%

Rifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies

Wang¹,

Maimaitiaili²,

Wang³

et al. 2021

IDR

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Spinal tuberculosis has been a common clinical extrapulmonary tuberculosis in recent years. The general anti-tuberculosis drug treatment cycle is long, with unsatisfactory efficacy. This study focused on the preparation and evaluation of rifapentine polylactic acid sustained-release microsphere complex for spinal tuberculosis therapy. Methods: Rifapentine polylactic acid sustained-release microspheres (RPSMs) were prepared through the double emulsion solvent evaporation method, and RPSMs were combined with hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite material to obtain drugloaded, sustained-release complex. We evaluated the complex for dynamics of drug release and osteogenic ability using in vitro release test, alkaline phosphatase and alizarin red staining, real-time PCR and Western blot. A rabbit model of a spinal tuberculosis defect was established and repaired using HA/β-TCP or complex. The ability of anti-tuberculosis and tissue repair effects of the complex were evaluated through in vivo experiments. Results: The complex constructed of RPSMs and HA/β-TCP demonstrated a long drug release time, with no significant inhibition of cell osteogenic differentiation in vitro experiments. Postoperative macroscopic observation, immunohistochemical staining and Nilsson histological scores showed that the complex has good effects on the tissue repair. Moreover, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), important indexes of inflammation, decreased to normal levels in the complex group. Conclusion:In vitro and in vivo experiments demonstrated that the complex constructed of RPSMs and HA/β-TCP effectively treated spinal tuberculosis. Therefore, the complex represents a promising approach for the treatment of spinal tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Rifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies

Wang¹,

Maimaitiaili²,

Wang³

et al. 2021

IDR

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“…The novel methods of administration of propranolol include propranolol-loaded mesoporous silica nanoparticles and continuous delivery from liposomes-in-microspheres. Despite promising results in studies of tumor inhibition in mice, the safety of this type of therapy is yet to be established [26,27].…”

Section: Propranololmentioning

confidence: 99%

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Kowalska

Dębek

Matuszczak

2021

JCM

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Infantile hemangiomas are the most common benign vascular tumors in infancy. This review includes an update on the current knowledge on pathogenesis, a discussion on indications for treatment, and a review of the mechanisms underlying the different treatment methods. Although most infantile hemangiomas require only active observation because of their natural course, which results in involution, about 10% present with complications that require immediate treatment. The basic treatment includes systemic and topical options. In cases of insufficient response or rebound growth, other forms of treatment should be considered. In some cases, combined therapy might be initiated.

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“…Propranolol-loaded liposomes-in-microsphere (PLIM) is another form of prolonged delivery of Propranolol, which showed enhanced therapeutic effects when compared with free Propranolol [62].…”

Section: β-Blocker Therapymentioning

confidence: 99%

Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics

Luca¹,

Miron²,

Trandafir³

et al. 2021

Rom J Morphol Embryol

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Infantile hemangiomas (IHs) are the most frequent pediatric benign vascular tumors, with a reported incidence of 5% to 10%. They have self-limiting evolution pattern divided into a growth phase in the first 12 months and a regression one, that may take up to 10 years. Occasionally, hemangiomas might lead to local or systemic complications, depending on their morphological characteristics. The first line of treatment is β-blockers, such as Propranolol, Timolol, Nadolol, administered either locally or systemically. Newer therapeutic strategies involving laser therapy and angiotensin-converting enzyme inhibitors are being studied, while older treatment modalities like corticosteroids, Imiquimod, Vincristine, Bleomycin and Interferon-α have become second line therapy options. Before establishing the appropriate treatment, clinical, histological, and imaging investigations are required.

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Continuous delivery of propranolol from liposomes-in-microspheres significantly inhibits infantile hemangioma growth

Cited by 24 publications

References 30 publications

Rifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies

Rifapentine Polylactic Acid Sustained-Release Microsphere Complex for Spinal Tuberculosis Therapy: Preparation, in vitro and in vivo Studies

Infantile Hemangiomas: An Update on Pathogenesis and Treatment

Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics

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