Continuous Catalytic Hydrogenation of a Key Intermediate of Riluzole Using a Micropacked-bed Reactor

Yang, Shangjin; Ming, Weixing; Liu, Song; Wei, Wei; Lu, Jianjun; Gong, Dangsheng; Wang, Jing; Zuo, Cuncun; Huang, Hongtao; Yan, Dongmao

doi:10.1246/cl.210716

Cited by 3 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data of Figures 2,3,4,6,7,8,9,10 are tabulated in the Supporting Information (Figures 1 and 5 do not have any data).…”

Section: Data Availability Statementmentioning

confidence: 99%

See 1 more Smart Citation

Liquid–liquid mass transfer and pressure drop behavior in micro‐packed beds with different shaped packings

Zhang,

et al. 2024

AIChE Journal

View full text Add to dashboard Cite

In this work, the liquid–liquid two‐phase pressure drop and mass transfer characteristics in micro‐packed beds with different shaped packing are investigated. The experimental results show that the liquid–liquid mass transfer performance of micro‐packed bed is significantly affected by both apparent flow rates and phase ratio. By changing the characteristic size of the micro‐packed bed, the experimental results show that the average volume mass transfer coefficient has no obvious correlation with the length of the bed, which indicates that the flow and dispersion behavior along the length of the micro‐packed bed is basically stable. By considering dispersion strengthening, vortex strengthening and size effect, a semi‐empirical model for predicting liquid–liquid mass transfer performance in a micro‐packed bed is established for the first time. The model is in good agreement with the experimental results and has strong applicability to various shaped packings. In addition, by considering the contribution of inertia force, viscous force and interfacial tension to energy dissipation, a semi‐empirical model of liquid–liquid two‐phase pressure drop in a micro‐packed bed is established. The pressure drop prediction model can also be applied to different shaped packings.

show abstract

“…The data of Figures 2,3,4,6,7,8,9,10 are tabulated in the Supporting Information (Figures 1 and 5 do not have any data).…”

Section: Data Availability Statementmentioning

confidence: 99%

“…Micro-packed bed technology has been widely used in oxidation reaction, 1,2 hydrogenation reaction, [3][4][5] deprotection reaction, 6 and catalyst screening. [7][8][9] The micro-packed bed utilizes hundred-micron to submillimeter packing as its core components, enabling a continuous redispersion process throughout the channel.…”

Section: Introductionmentioning

confidence: 99%

Liquid–liquid mass transfer and pressure drop behavior in micro‐packed beds with different shaped packings

Zhang,

et al. 2024

AIChE Journal

View full text Add to dashboard Cite

show abstract

“…Micro‐packed bed technology has been widely applied in oxidation reactions 1,2 and hydrogenation reactions 3–5 . The main advantage of micro‐reactor systems with micro‐dispersion structures as core components is their small dispersion scale.…”

Section: Introductionmentioning

confidence: 99%

Dispersion behavior of liquid–liquid and gas–liquid two‐phase flow in micro‐packed beds

Zhang,

Xu,

Chen

2023

AIChE Journal

View full text Add to dashboard Cite

Micro‐packed beds have the advantages of excellent heat and mass transfer efficiency and high safety, which have been successfully applied to hydrogenation and oxidation reactions. The dispersion behavior of multiphase flow is closely related to mass transfer and reaction performance. However, the study of dispersion law in micro‐packed beds is not sufficient. This work investigated the dispersion behavior of gas–liquid/liquid–liquid two‐phase flow in micro‐packed beds. The average size and distribution of droplets/bubbles were measured in different systems. Key parameters that affect the dispersion characteristics of the two phases were observed experimentally, including gas/liquid phase flow rate, size of the packing, and physical parameters of the systems. The experimental results showed that gas–liquid and liquid–liquid dispersion processes exhibited different characteristics due to the different physical parameters of liquid and gas as the dispersed phase. The fracture driving force of the gas–liquid process was mainly from the continuous liquid phase, while the fracture driving force of the liquid–liquid process came from both the dispersed phase and the continuous phase.

show abstract

Micropacked‐bed Reactor for Continuous Hydrogenation of Aromatic Dinitro Compounds

Yang¹,

Liu²,

Ming³

et al. 2022

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

Due to the intricacy aromatic dinitro compound hydrogenation processes, it is difficult to attain high conversion and selectivity using merely modified catalysts in batch reactors. The micropacked-bed reactor (μPBR) offers efficient heat and mass transfer, a precise and controllable reaction process, and a high level of safety. In this work, the hydrogenation of 2,4dinitroanisole was selected as the model reaction, and a variety of catalysts were utilized in the continuous flow system based on μPBR for hydrogenation of 2,4-dinitroanisole. During 960 minutes of operation, the synthesis of 2,4-diaminoanisole was carried out using a Pd (OH) 2 /C catalyst and the optimal process condition, yielding 100 % conversion, 99.5 % selectivity, and the favorable durability. For the hydrogenation of relevant aromatic dinitro compounds, the continuous flow system demonstrates exceptional performance.

show abstract

Continuous Catalytic Hydrogenation of a Key Intermediate of Riluzole Using a Micropacked-bed Reactor

Cited by 3 publications

References 22 publications

Liquid–liquid mass transfer and pressure drop behavior in micro‐packed beds with different shaped packings

Liquid–liquid mass transfer and pressure drop behavior in micro‐packed beds with different shaped packings

Dispersion behavior of liquid–liquid and gas–liquid two‐phase flow in micro‐packed beds

Micropacked‐bed Reactor for Continuous Hydrogenation of Aromatic Dinitro Compounds

Contact Info

Product

Resources

About