Continuous and reactive nanocrystallization: New concepts and processes for dual-use advances

Spitzer, Denis; Pichot, Vincent; Pessina, Florent; Schnell, Fabien; Klaumünzer, Martin; Blas, Lucia

doi:10.1016/j.crci.2016.06.009

Cited by 3 publications

(4 citation statements)

References 29 publications

(22 reference statements)

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“…With the advancement in pharmaceutical technology, supercritical antisolvent precipitation using supercritical fluids could be used in nanocrystal production. Supercritical fluids behave like liquids and convert to gas above their critical point e.g., carbon dioxide, ammonia, ethane, ethylene etc [49]. The drug in a solvent is sprayed on supercritical antisolvent in a chamber, resulting in rapid nucleation and nanocrystal formation.…”

Section: Bottom-up Methodsmentioning

confidence: 99%

Nano-Crystallization: An Efficient Technology for Targeting Chemotherapeutic Drugs

Iqbal¹,

Delié²

2021

Preprint

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Presently, nano-crystallization is widely accepted for increasing the solubility and biological barrier permeability of poorly soluble drugs. It improves the bioavailability of therapeutic agents, increasing the effectiveness for treating diseased conditions, and could be safely administered by oral, parenteral, or transdermal routes. Drug nanocrystals are drug particles coated with a thin polymer layer to enhance their stability and could be decorated with ligands for active targeting. In addition, nanocrystals, due to their morphological properties, improve cell internalization. Therefore, passive targeting by high cellular uptake and retention in the mononuclear phagocyte system (MPS) may be expected. Drug nanocrystals are formulated by either top-down or bottom-up methods and could be scaled up for industrial manufacturing. In the past few decades, nanocrystal formulation has been increasingly studied to overcome the limitations of BCS Class II and IV chemotherapeutic agents. The study of cytotoxic effects of drug formulation on cell lines gives an insight for estimating its in-vivo biodistribution. This review highlights the role of morphology, stabilizer, and ligand conjugation on drug targeting and cellular uptake in cancer cells, as well as a brief discussion on nanocrystal production.

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Section: Bottom-up Methodsmentioning

confidence: 99%

Nano-Crystallization: An Efficient Technology for Targeting Chemotherapeutic Drugs

Iqbal¹,

Delié²

2021

Preprint

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“…Concerning RESS, the procedure can create nanoorganic materials, for example, explosives or nano size drugs by crystallizing them in a reasonable supercritical dissolvable, for example, high pressure carbon dioxide and high temperature. This is accomplished in a continuous way [50]. Even though these strategies can produce constantly well dried formulation, because of the low solvency of the materials in carbon dioxide, the production amount limit is still low, barely achieving production limits more than 1 gram/hour.…”

Section: Rapid Expansion In Supercritical Solutions and Spray Flash Ementioning

confidence: 99%

“…The extraordinary pressure drops from the highpressure zone to the low-pressure zone with ensuing temperature drop initiate evaporation instantaneously and consequent crystallization of the particles that was dissolved in the original solution. After its crystallization, the item can be trapped in a cyclone, in an electrical precipitator or in filter [50].…”

Section: Rapid Expansion In Supercritical Solutions and Spray Flash Ementioning

confidence: 99%

Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

Joshi

Chandra

Jain

et al. 2019

PNT

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Most of the active pharmaceutical ingredient used in the management of disease have poor water solubility and offer grueling problems in drug formulation development since low solubility is generally associated with poor dissolution characteristics which leads to poor oral bioavailability. The great challenge for the development of a pharmaceutical product is to create its new formulation and drug delivery system to limit solubility problems of existing drug candidate. Limited drug-loading capacity requires a large amount of carrier material to get appropriate encapsulation of the drug, which is another major challenge in the development of pharmaceutical product which could be resolved by developing nanocrystals (NCs). A significant research in the past few years has been done to develop NCs which helps in the delivery of poorly water soluble drugs via different routes. The technology could continue to thrive as a useful tool in pharmaceutical sciences for the improvement of drug solubility, absorption and bioavailability. Many crystalline compounds have pulled in incredible consideration much of the time, due to their ability to show good physical and chemical properties when contrasted with their amorphous counterparts. Nanocrystals have been proven to show atypical properties compared to the bulk. This review article explores the principles of the important nanocrystallization techniques including NCs characterization and its application.

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“…The nanostructured thermites and explosives (NSTEX) are prepared by dry mixing of a nanothermite with high explosives in sub-micrometer-or nanopowders (e. g. RDX, HMX, PETN, CL-20). Explosives can be prepared as fine powders by different techniques, but the Spray Flash-Evaporation (SFE) process developed and patented by NS3E laboratory has proven to be by far the most efficient for this purpose [88][89][90][91][92][93]. NSTEX can be considered as the missing link between pyrotechnics and explosives.…”

Section: Hybrid Compositionsmentioning

confidence: 99%

Nanothermites: A short Review. Factsheet for Experimenters, Present and Future Challenges

Comet

Martin

Schnell

et al. 2018

Propellants Explo Pyrotec

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Nanothermites are the most important family of energetic materials in contemporary pyrotechnics. This article traces the main research which was carried out in this still recent domain and the challenges that remain to be overcome. The academic effort of past two decades has brought nanothermites from the status of laboratory curiosities to the one of pre‐industrial materials. Different aspects of nanothermites are discussed in order to provide valuable information to scientists experimenting in this domain. Experimental details on the preparation and the disposal of nanothermites are reported. The current research on nanothermites deals with: (i) the development of new aluminothermic mixtures; (ii) the preparation of hybrid compositions by combining nanothermites with explosive nanopowders and (iii) the study of reactive properties. From an academic standpoint, the future challenges are to find new compositions and effects. From a practical standpoint, the effort must focus on the integration of nanothermites and their derivatives in pyrotechnic systems. Toxicological concerns are expected to become increasingly important over the next decade.

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Continuous and reactive nanocrystallization: New concepts and processes for dual-use advances

Cited by 3 publications

References 29 publications

Nano-Crystallization: An Efficient Technology for Targeting Chemotherapeutic Drugs

Nano-Crystallization: An Efficient Technology for Targeting Chemotherapeutic Drugs

Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

Nanothermites: A short Review. Factsheet for Experimenters, Present and Future Challenges

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