Continuous and intermittent running to exhaustion at maximal lactate steady state: Neuromuscular, biochemical and endocrinal responses

Dittrich, Naiandra; Lucas, Ricardo Dantas de; Maioral, Mariana Franzoni; Diefenthaeler, Fernando; Guglielmo, Luiz Guilherme Antonacci

doi:10.1016/j.jsams.2012.12.001

Cited by 9 publications

(9 citation statements)

References 26 publications

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“…These results suggested that restraint brings more stress than forced swimming exercise. In addition, it has been reported that cortisol level is significantly increased by resistance training 48 or intermittent exercise training 49 . However, these researches were focused on relatively high intensity exercise that could induce exhaustion.…”

Section: Discussionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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[Purpose]To determine whether voluntary exercise (wheel running) has the potential of relieving stress. [Methods]In this study, restraint stress with or without voluntary wheel running was performed for mice housed in individual cages. A total of 21 ICR male mice were assigned into control (CON), restraint stress with voluntary exercise (RSVE), or restraint stress (RS) without voluntary exercise groups (n = 7 each). [Results]No significant difference in body weight increase was found among the three groups, although CON and RS groups had a tendency of having smaller body weight increase compared to the RSVE group. No significant difference in the expression level of liver heat shock protein 70, Bcl-2, or p53 was found among the three groups. However, caspase-3 protein level in RS group was significantly higher than that in the other two groups. Blood cortisol concentration in RS was higher (p < 0.05) than that in RSVE or CON group. It was the lowest (p < 0.05) in the RSVE group. [Conclusion]Our findings suggest that apoptosis caused by chronic restraint stress might be suppressed by voluntary exercise in mice.

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Section: Discussionmentioning

confidence: 99%

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Seo

Park

Choi

et al. 2016

Journal of Exercise Nutrition &Amp; Biochemistry

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“…Calcium and phosphorus showed a lower concentration value during the second week and the last recovery phase with respect to the first week and baseline level. This diminution could be the result of an increased urinary mineral excretion, greater endogenous fecal excretion, and decreased mineral absorption efficiency in the intestine [10]. Another possible cause could be that, in the course of exercise, decreases production of parathyroid hormone by parathyroid glands [2].…”

Section: Discussionmentioning

confidence: 99%

“…Sodium, chloride, magnesium, calcium, potassium, and phosphorus are important for the correct conduction of electrical impulse through nervous system and muscle and for the muscle contraction [10,19,32]; iron is important for oxygen blood-binding potential, otherwise lactate increment may cause muscular damage and pain [9,19]. Imbalance of serum electrolyte with concomitant increase of blood lactate concentration could be responsible for decline of athletic performances [23][24][25]28].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Electrolytes and Blood Lactate Concentration During Repeated Maximal Exercise in Horse

Assenza

Bergero

Congiu

et al. 2014

Journal of Equine Veterinary Science

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Modifications of some serum electrolyte concentration during two international *** show jumping competition performed in two consecutive weekends were evaluated. Serum sodium (Na), chloride (Cl), magnesium (Mg), potassium (K), phosphorous (P), calcium (Ca), iron (Fe), and blood lactate on 14 well-trained Italian saddle horses were assessed. Blood samples were collected before the beginning of the competition (T0B), within 10 minutes after the end of race (R1, R2, and R3), and on the day after competition (T0R). The same procedure was followed on the second weekend (R4, R5, R6, and T1R). One-way repeated measures analysis of variance was applied on collected data, and a significant effect on sampling time (P < .05) on all parameters studied was found. These results suggest that serum electrolytes and blood lactate concentration are responsive to intense exercise and could be considered an important factor for a correct management training's planning.

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“…Interestingly, altering the intensity and damaging-potential of exercise can shift EV production to favor exosome secretion (Oliveira et al, 2018). This may be a mechanism to confer a more rapid repair and regenerative response from surrounding target cells after a more damaging stimulus—as exosomes may be more efficiently taken up (Dittrich et al, 2013). Different pathways for exosome and ectosome uptake also impact on their intracellular shuttling and thus potential intracellular site of action by their cargoes.…”

Section: Extracellular Vesicle Uptake By the Target Cellsmentioning

confidence: 99%

Contribution of Extracellular Vesicles in Rebuilding Injured Muscles

Bittel

Jaiswal

2019

Front. Physiol.

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Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue function. Myofiber repair and regeneration requires coordinated action of various intercellular signaling factors—including proteins, inflammatory cytokines, miRNAs, and membrane lipids. It is increasingly being recognized release and transmission of these signaling factors involves extracellular vesicle (EV) released by myofibers and other cells in the injured muscle. Intercellular signaling by these EVs alters the phenotype of their target cells either by directly delivering the functional proteins and lipids or by modifying longer-term gene expression. These changes in the target cells activate downstream pathways involved in tissue homeostasis and repair. The EVs are heterogeneous with regards to their size, composition, cargo, location, as well as time-course of genesis and release. These differences impact on the subsequent repair and regeneration of injured skeletal muscles. This review focuses on how intracellular vesicle production, cargo packaging, and secretion by injured muscle, modulates specific reparative, and regenerative processes. Insights into the formation of these vesicles and their signaling properties offer new understandings of the orchestrated response necessary for optimal muscle repair and regeneration.

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Continuous and intermittent running to exhaustion at maximal lactate steady state: Neuromuscular, biochemical and endocrinal responses

Cited by 9 publications

References 26 publications

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice

Evaluation of Serum Electrolytes and Blood Lactate Concentration During Repeated Maximal Exercise in Horse

Contribution of Extracellular Vesicles in Rebuilding Injured Muscles

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