Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice

Beltrán‐Debón, Raúl; Rull, Anna; Rodríguez-Sanabria, Fernando; Iswaldi, Ihsan; Herranz-López, María; Aragonès, Gerard; Camps, Jordi; Alonso-Villaverde, Carlos; Menéndez, Javier A.; Micol, Vicente; Segura‐Carretero, Antonio; Joven, Jorge

doi:10.1016/j.phymed.2010.11.008

Cited by 79 publications

(49 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…*** P < 0.001. compared to the 2-fold inhibition observed under basal conditions. A recent study by Beltrán-Debóna et al [58] showed negligible effects of Rooibos in animals with no metabolic disturbance, while significant reductions in serum cholesterol, triglyceride and free fatty acid concentrations were observed in hyperlipemic mice.…”

Section: The Influence Of Rooibos and Flavonoids On H295r Metabolismmentioning

confidence: 93%

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

Schloms

Storbeck

Swart

et al. 2012

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

Section: The Influence Of Rooibos and Flavonoids On H295r Metabolismmentioning

confidence: 93%

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

Schloms

Storbeck

Swart

et al. 2012

The Journal of Steroid Biochemistry and Molecular Biology

View full text Add to dashboard Cite

“…Some flavonoids have hepatoprotective potential (Harborne and Williams, 2000), and quercetin (Q) is one of the most potent flavonoids (Ader et al, 2000). Several studies, primarily with rodents and pigs, found decreased plasma lipid levels (Hoek-van den Hil et al, 2013;Jung et al, 2013;Wein and Wolffram, 2014) and prevention or reduction of lipid accumulation in the liver after Q treatment (Aguirre et al, 2011;Beltrán-Debón et al, 2011;Joven et al, 2012). The underlying mechanisms of these effects included an improvement in the Ω-and β-oxidation of FA in the liver and an upregulation of the genes involved in lipid metabolism (Kobayashi et al, 2010;Jung et al, 2013;Hoek-van den Hil et al, 2013).…”

Section: Effects Of a 6-wk Intraduodenal Supplementation With Quercetmentioning

confidence: 99%

Effects of a 6-wk intraduodenal supplementation with quercetin on energy metabolism and indicators of liver damage in periparturient dairy cows

Stoldt

Derno

Nürnberg

et al. 2015

Journal of Dairy Science

View full text Add to dashboard Cite

Periparturient dairy cows experience metabolic challenges that result in a negative energy balance (EB) and a range of postpartum health problems. To compensate for the negative EB, cows mobilize fatty acids from adipose tissues, which can lead to fatty liver disease, a periparturient metabolic disorder. Flavonoids, such as quercetin (Q), are polyphenolic substances found in all higher plants and have hepatoprotective potential and the ability to prevent or reduce lipid accumulation in the liver. In ruminants, few studies on the metabolic effects of Q are available, and thus this study was conducted to determine whether Q has beneficial effects on EB, lipid metabolism, and hepatoprotective effects in periparturient dairy cows. Quercetin was supplemented intraduodenally to circumvent Q degradation in the rumen. Cows (n=10) with duodenal fistulas were monitored for 7wk. Beginning 3wk before expected calving, 5 cows were treated with 100mg of quercetin dihydrate per kilogram of body weight daily in a 0.9% sodium chloride solution for a total period of 6wk, whereas the control cows received only the sodium chloride solution. The plasma flavonoid levels were higher in the Q-treated cows than in the control cows. A tendency for higher postpartum (pp) than antepartum (ap) plasma flavonoid levels was observed in the Q-treated cows than in the controls, which was potentially caused by a reduced capacity to metabolize Q. However, the metabolic status of the Q-treated cows did not differ from that of the control cows. The pp increases in plasma aspartate aminotransferase and glutamate dehydrogenase activities were less in the Q-treated cows than in the control cows. The Q had no effect on energy expenditures, but from ap to pp the cows had a slight decline in respiratory quotients. Irrespective of the treatment group, the oxidation of fat peaked after calving, suggesting that the increase occurred because of an increased supply of fatty acids from lipomobilization. In conclusion, supplementation with Q resulted in lower pp plasma aminotransferase and glutamate dehydrogenase, which indicated reduced liver damage. However, the direct effects of Q on the liver and the implications for animal performance remain to be investigated.

show abstract

“…Other major phenolic compounds present in rooibos include �avones (orientin, isoorientin, vitexin, isovitexin, luteolin, and chrysoeriol), �avanones (dihydro-orientin, dihydro-isoorientin, and hemiphlorin), and �avonols (quercetin, hyperoside, isoquercitrin, and rutin) [52,[57][58][59][60]. Phenolic acids, lignans, �avone diglycosides, (�)-catechin, a phenylpyruvic acid glycoside, the �avonol quercetin-3-O-robinobioside, and the coumarins, esculetin and esculin have also been identi�ed [52,[61][62][63][64].…”

Section: Phytochemistry and Biologicalmentioning

confidence: 99%

Commercially Important Medicinal Plants of South Africa: A Review

Street

Prinsloo

2012

Journal of Chemistry

138

114

View full text Add to dashboard Cite

ere is a growing interest in natural plant-based remedies as a source for commercial products. Around 80% of the South African population use traditional medicines to meet their primary health care needs; however, only a few South African medicinal plants have been exploited to their full potential in terms of commercialization. e opportunity for bioprospecting of plant compounds for novel pharmaceuticals remains largely untapped. Certain renowned medicinal plants of international acclaim including buchu and rooibos are currently contributing to local enterprise; however, other exciting opportunities exist for commonly used plants which have not yet reached the international arena. is paper focuses on the key research and development contributions of 10 commercially important medicinal plants of South Africa. �raditional uses, scienti�c validation, commercialisation developments, as well as both potential opportunities and setbacks are discussed.

show abstract

Continuous administration of polyphenols from aqueous rooibos (Aspalathus linearis) extract ameliorates dietary-induced metabolic disturbances in hyperlipidemic mice

Cited by 79 publications

References 38 publications

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: Quantification of steroid intermediates and end products in H295R cells

Effects of a 6-wk intraduodenal supplementation with quercetin on energy metabolism and indicators of liver damage in periparturient dairy cows

Commercially Important Medicinal Plants of South Africa: A Review

Contact Info

Product

Resources

About