Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase

Klocker, Josef; Perkmann, Reinhold; Klein-Weigel, Peter; Mörsdorf, Gabriele; Drasche, Astrid; Klingler, Antón; Fraedrich, Gustav; Schwelberger, H. G.

doi:10.1016/j.vph.2004.02.002

Cited by 16 publications

(8 citation statements)

References 27 publications

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“…To date, little data is available on the prevalence of this enzymatic deficiency related to gender, and it is inconclusive. Klockler et al found no differences in plasma DAO activity between men and women, although the number of individuals considered was scarce (n = 28) [ 93 ]. Likewise, the study performed by Izquierdo et al reported similar percentages of DAO deficiency in migraine-suffering women (83%) and men (90%) [ 66 ].…”

Section: Histamine Intolerancementioning

confidence: 99%

Histamine Intolerance: The Current State of the Art

et al. 2020

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Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st century. Although interest in histamine intolerance has considerably grown in recent years, more scientific evidence is still required to help define, diagnose and clinically manage this condition. This article will provide an updated review on histamine intolerance, mainly focusing on its etiology and the existing diagnostic and treatment strategies. In this work, a glance on histamine intoxication will also be provided, as well as the analysis of some uncertainties historically associated to histamine intoxication outbreaks that may be better explained by the existence of interindividual susceptibility to ingested histamine.

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Section: Histamine Intolerancementioning

confidence: 99%

Histamine Intolerance: The Current State of the Art

et al. 2020

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“…Furthermore, the total histamine degradation capacity can be measured (69). Plasma activity of DAO, which generally is relatively low, may be increased by the liberation of tissue-bound DAO through an injection of heparin (127)(128)(129)(130)(131)(132), which was the main method used before the development of more sensitive assays. Serum DAO concentrations showed no significant daily variations and no significant sex differences (97).…”

Section: Practical Consequencesmentioning

confidence: 99%

Histamine and histamine intolerance

Maintz

Novak

2007

The American Journal of Clinical Nutrition

697

665

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Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the main enzyme for the metabolism of ingested histamine. It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after mediator release. Conversely, histamine N-methyltransferase, the other important enzyme inactivating histamine, is a cytosolic protein that can convert histamine only in the intracellular space of cells. An impaired histamine degradation based on reduced DAO activity and the resulting histamine excess may cause numerous symptoms mimicking an allergic reaction. The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance. Symptoms can be reduced by a histamine-free diet or be eliminated by antihistamines. However, because of the multifaceted nature of the symptoms, the existence of histamine intolerance has been underestimated, and further studies based on double-blind, placebo-controlled provocations are needed. In patients in whom the abovementioned symptoms are triggered by the corresponding substances and who have a negative diagnosis of allergy or internal disorders, histamine intolerance should be considered as an underlying pathomechanism.

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“…Moderate influence on DAO was caused by isoniazid and metamizole, acetyl cysteine and amitriptyline (> 20%). Interestingly, another group of clinically used drugs – glycosaminoglycans can temporarily increase the DAO serum level [4]. Indeed, although DAO is expressed mainly in enterocytes and kidney epithelial cells, tissue-bound DAO can be released into circulation following stimulation with heparin with its serum half-life of about an hour [5].…”

Section: Introductionmentioning

confidence: 99%

Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients

Wagner¹,

Buczyłko²,

Zielińska‐Bliźniewska³

et al. 2019

pdia

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IntroductionHistamine is the major mediator of IgE- and non-IgE-mediated allergic reactions upon allergen or hapten contact. Reduced histamine degradation capacity was associated with atopic eczema as well as with non-immunological histamine intolerance. Higher blood serum histamine level concomitant with decreased intestinal diamine oxidase activity were observed in patients with food allergy.AimTo evaluate the relationship between patients’ blood diamine oxidase (DAO) activity/histamine status and their reactivity to time-resolved histamine skin prick test in respect to vulnerability to allergic diseases.Material and methodsFifty-three patients were examined with skin prick tests (SPT) and patch tests for suspected presence of either IgE- or non-IgE-mediated allergy. All individuals were skin prick tested with histamine and the resolution of the wheal was monitored for 50 min. Blood DAO activity and histamine concentration were measured with a radio-extraction radioimmunoassay.ResultsTime-resolved histamine skin prick testing revealed presence of wheals which were 35% larger in diameter in 47% of examined subjects at 20 min of the test. These patients exhibited significantly compromised time-course wheal resolution (wheal ≥ 3 mm at 50 min) compared to a group of patients with the normal-rate of wheal resolution (wheal = 0 mm at 50 min). Within a group of subjects exhibiting impaired wheal resolution, 61% of patients were diagnosed allergic compared to 50% in a group of patients with a normal rate of wheal resolution. Finally, allergic patients were characterized by a significantly lower DAO activity and higher histamine content compared to healthy subjects.ConclusionsThe results of this study indicate that patients with IgE- or non-IgE-mediated allergy are likely to have low DAO blood activity and may concomitantly suffer from histamine intolerance. Furthermore, our results suggest that allergic patients are more likely to develop an excessive SPT reaction. Our results emphasize caution in interpretation of the SPT results in allergic patients with diagnosed histamine intolerance or histamine/DAO activity imbalance.

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Continuous administration of heparin in patients with deep vein thrombosis can increase plasma levels of diamine oxidase

Cited by 16 publications

References 27 publications

Histamine Intolerance: The Current State of the Art

Histamine Intolerance: The Current State of the Art

Histamine and histamine intolerance

Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients

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