Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists

Krasavin, Mikhail; Lukin, Alexey; Bakholdina, Anna; Zhurilo, Nikolay; Onopchenko, Oleksandra; Borysko, Petro; Zozulya, Sergey; Moore, Daniel; Tikhonova, Irina G.

doi:10.1016/j.ejmech.2017.09.019

Cited by 11 publications

(2 citation statements)

References 21 publications

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“…40 Nevertheless, in ref. [41][42][43], the authors propose an efficient replacement of the phenylpropionic acid residue by a more polar 1,3,4-thiadiazole ring (Fig. 3, compound A) while Organic & Biomolecular Chemistry Paper maintaining the antidiabetic efficacy of the obtained derivatives.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, spectroscopic characterization, computational analysis, and in vitro α-amylase and α-glucosidase evaluation of 3-aminopyridin-2(1H)-one based novel monothiooxamides and 1,3,4-thiadiazoles

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Design, synthesis, spectroscopic characterization, computational analysis, and in vitro α-amylase and α-glucosidase evaluation of 3-aminopyridin-2(1H)-one based novel monothiooxamides and 1,3,4-thiadiazoles

et al. 2022

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“…Sulfur-containing compounds are ubiquitous structural motifs in natural products, biologically active compounds, materials, and synthetic intermediates . Among them, the 1,2,4-thiadiazole derivatives have broad biological and pharmaceutical properties . Therefore, the synthesis of 1,2,4-thiadiazole derivatives has received considerable attention.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Oxidative Intramolecular N–S Bond Formation: Synthesis of 3-Substituted 5-Amino-1,2,4-Thiadiazoles

Yang

Zhang

et al. 2020

J. Org. Chem.

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A facile and efficient protocol for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles has been developed through the electro-oxidative intramolecular dehydrogenative N–S bond formation of imidoyl thioureas. Various 1,2,4-thiadiazole derivatives were synthesized in good to excellent yields with broad substrate scope and excellent functional group tolerance under catalyst- and oxidant-free electrolytic conditions at room temperature.

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Electrochemical Synthesis of 1,2,4‐Thiadiazoles through Intermolecular Dehydrogenative S‐N Coupling

Xie

Yang

et al. 2019

Adv Synth Catal

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An electrochemical intermolecular dehydrogenative coupling reaction of isothiocyanates with 2‐aminopyridines/amidines was developed. Using n‐Bu4NI as the catalyst and electrolyte, 1,2,4‐thiadiazoles and pyrido‐fused 1,2,4‐thiadiazoles were readily accessed with good to excellent efficiency under the undivided electrolysis conditions. This electrochemical approach obviates the use of external oxidants and transition‐metal catalysts.

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Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists

Cited by 11 publications

References 21 publications

Design, synthesis, spectroscopic characterization, computational analysis, and in vitro α-amylase and α-glucosidase evaluation of 3-aminopyridin-2(1H)-one based novel monothiooxamides and 1,3,4-thiadiazoles

Design, synthesis, spectroscopic characterization, computational analysis, and in vitro α-amylase and α-glucosidase evaluation of 3-aminopyridin-2(1H)-one based novel monothiooxamides and 1,3,4-thiadiazoles

Electrochemical Oxidative Intramolecular N–S Bond Formation: Synthesis of 3-Substituted 5-Amino-1,2,4-Thiadiazoles

Electrochemical Synthesis of 1,2,4‐Thiadiazoles through Intermolecular Dehydrogenative S‐N Coupling

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