Continued pharmacologic analysis of consummatory behavior in the albino rat

Lehr, David; Goldman, Warren

doi:10.1016/0014-2999(73)90057-5

Cited by 63 publications

(12 citation statements)

References 22 publications

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“…This suggests that depression of food intake is mediated extra-hypothalamically [16]. and is consistent with previous findings [47,48] of decreased serotonin associated with increased food intake and a decrease in turnover, resulting in hyperphagia [49,50].…”

supporting

confidence: 80%

“…This in turn leads to an increase in brain tryptophan conccntration, inducing an increascd synthesis and turnover of serotonin. When this is taken in conjunction with reports of serotonergic mechanisms of satiety [e.g., 47,48] it becomes possible to suggest that anorexia is mediated by serotonin. However, further studies [53] have shown that inhibition of serotonin synthesis can postpone but NOT eliminate the onset of anorexia, and others have failed to rcproduce previous findings [e.g., 54,55].…”

mentioning

confidence: 99%

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Malignant disease: nutritional implications of disease and treatment

Holmes

Dickerson

1987

Cancer Metast Rev

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Protein-energy malnutrition (PEM) is common in cancer patients and may develop into the syndrome known as 'cancer cachexia'. This is characterised by complex disturbances in carbohydrate, lipid, protein, and electrolyte metabolism. The aetiology is equally complex, with host and therapeutic factors contributing to the reduced food intake and effects on host tissues. Anorexia is of prime importance, differing in its cause from one patient to another and often presenting a barrier to successful nutritional support. Further research is necessary to elucidate the interaction of central and peripheral factors that may be involved in the aetiology of anorexia. Because of the interplay of biochemical, physiological, and psychological consequences of cancer, the nutritional support of the patient presents a considerable challenge to the caring professions.

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supporting

confidence: 80%

mentioning

confidence: 99%

Malignant disease: nutritional implications of disease and treatment

Holmes

Dickerson

1987

Cancer Metast Rev

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“…Though the pathogencsis of cancer anorexia is probably multifactorial, it has been suggested that serotonin and its precursor aminoacid tryptophan may play a crucial role (Krause et al, 1979;Krause et al, 1981;Cangiano, 1989). This hypothesis was based upon a number of theoretical and experimental data suggesting the role of the serotoninergic system in feeding behavior (Leher et al, 1973;Breisch et al, 1976;Wurtman et al, 1977). In recent years the existence of a tight relationship between eating behaviour and brain serotonin turnover has been confirmed in a series of different clinical and experimental conditions (Kennet and Curzon, 1988;Caballero et al, 1988;White et al, 1988;Ceci et al, 1989).…”

Section: Discussionmentioning

confidence: 94%

Plasma and CSF tryptophan in cancer anorexia

Cangiano¹,

Cascino²,

Ceci

et al. 1990

J. Neural Transmission

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Eighteen untreated cancer patients and ten sex- and age-matched healthy volunteers were studied. In all patients eating behavior was investigated by means of a specific questionnaire from which the presence of anorexia and anorexia-related symptoms was assessed. To investigate the role of tryptophan in cancer anorexia, fasting plasma and CSF levels of tryptophan and other neutral amino acids were assayed in patients and controls. Cancer patients showed abnormally high plasma free tryptophan levels. In case of patients with cancer anorexia a significant rise of the ratio in plasma between free and tryptophan/large neutral amino acids, competing with tryptophan for its brain entry, was observed. This increase was correlated to a consistent rise of CSF tryptophan levels suggesting a specific role of the serotoninergic system in the pathogenesis of cancer anorexia.

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“…However, reduced appetite (anorexia) is a clinically important problem and may result from spurious signals produced by the tumour causing a satiety response in the hypothalamus [6]. Changes in the metabolism of tryptophan may lead to an increased production of serotonin (5-hydroxytryptamine) thus affecting serotonergic mechanisms of satiety [7,8]. However, subsequent studies have suggested that, although serotonergic mechanisms may play a contributory role, other mechanisms must also be involved in the pathogenesis of anorexia [9-111. Whatever its cause, it is clear that PEM is a significant problem in cancer patients making nutritional assessment mandatory in their care.…”

Section: Introductionmentioning

confidence: 99%

Food Intake and Quality of Life in Cancer Patients

Holmes

Dickerson

1991

Journal of Nutritional Medicine

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Protein-energy malnutrition is of considerable importance in the clinical management of the cancer patient when it may be associated with a poor prognosis, a reduced response to therapy, an increased risk of therapeutic side-eflects and a reduced quality of life (QL). This paper reports the findings of three studies designed to evaluate food intake in hospitalized cancer patients and to investigate the relationship between total food consumption and the patient's QL. The findings indicate firstly that data provided through 24 h dietary recall bear little relationship to those obtained by direct weighing. The second study shows that three-day weighed intakes provide accurate data but are time-intensive, intrusive and disruptive to normal food distribution practices. The results suggest, however, that food consumption in hospitalized cancer patients is generally inadequate and, finally, that it is closely linked to QL although no clear cause and eflect relationship is demonstrated. Further research is clearly needed.

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Continued pharmacologic analysis of consummatory behavior in the albino rat

Cited by 63 publications

References 22 publications

Malignant disease: nutritional implications of disease and treatment

Malignant disease: nutritional implications of disease and treatment

Plasma and CSF tryptophan in cancer anorexia

Food Intake and Quality of Life in Cancer Patients

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