Background: Early detection of hypertension is necessary to reduce subsequent morbidity and mortality. The aim of our study was to determine the prevalence of hypertension and prehypertension in a high school students from Libreville, the capital city of Gabon and to identify their predisposing factors. Methods: This was a cross-sectional and analytical study carried out on a population of students enrolled in two establishments in Libreville during the 2018-2019 year school. Information of family history of hypertension, eating habits, consumption of alcohol and/or tobacco, taking oral contraception, age, gender, body mass index and blood pressure were collected. The NHBP and European Cardiology Society 2013 classifications were used for the analysis of blood pressure in children and young adults respectively.Results: A total of 613 students with mean age of 20.3 ± 2.5 years were included. The sex ratio was 2.3. The prevalence of hypertension was 19.4% and the predisposing factors were: obesity (OR: 2.62, [1.30-5.27]), overweight (OR: 2.52, [1.30-4.89]), male sex (OR: 2.13, [1.29-3.52]) and age over 18 (OR: 13.5, [6.6-27.4]). The prevalence of prehypertension was 23.0% and the predisposing factors were: obesity (OR: 4.38, [1.03-18.6]), overweight (OR: 2.16, [1.03-4.53]), the male sex (OR: 1.72, [1.10-2.78]) and the age below 18 years (OR: 1.21, [0, 57 to 2.56]). Conclusions: Hypertension and prehypertension are frequent in school students from Libreville. Awareness on predisposing factors and screening campaigns within school establishments are necessary to reduce complications in adulthood.