Continued Decline of Aqueous Interleukin-8 After Multiple Intravitreal Injections of Ganciclovir for Cytomegalovirus Retinitis

Wang, Bin; Tian, Bei; Tao, Yong; Hou, Jing; Zhao, Xiang‐Yu; Li, Xiaoxin

doi:10.1089/jop.2013.0241

Cited by 14 publications

(8 citation statements)

References 29 publications

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“…Levels of CMV in anterior aqueous humor of patients with CMVR could be an indicator of disease activity just like levels of HIV in serum of patients with AIDS [13]. Our previous study has reported that IL-8 was significantly associated with the aqueous level of CMV copies and continuously declined during multiple intravitreal injections of antiviral drugs [14]. Considering the level of Cu had positive correlation with both of the concentration of IL-8 and CMV DNA load in present study.…”

Section: Discussionsupporting

confidence: 62%

“…All of the patients received intravitreal injection of ganciclovir (IVG), which was started immediately when they were diagnosed as CMVR. The injection method was briefly described in detail as previous reports [13,14]. Totally, 3.0 mg ganciclovir was injected with a 27-gauge needle transconjunctivally at 3-3.5 mm from the limbus.…”

Section: Treatment Of Cytomegalovirus Retinitismentioning

confidence: 99%

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Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis

Zhou

Wang

et al. 2019

Eye

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Purpose To investigate the alterations of trace elements levels in aqueous humor of patients with cytomegalovirus retinitis (CMVR). Methods A total of 15 eyes of 11 patients with CMVR and 24 eyes of 24 patients with senile cataract as control group were enrolled. Aqueous humor samples were assessed for calcium (Ca), potassium (K), magnesium (Mg), sodium (Na), phosphorus (P), titanium (Ti), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), nickel (Ni), copper (Cu), zinc (Zn), selenium (Se), strontium (Sr), and lead (Pb) by using inductively coupled-plasma-mass-spectrometry. Meanwhile, we examined the concentration of the CMV DNA load by using PCR and the concentration of interleukin (IL)-8 by using a cytometric bead array. Results In patients with CMVR, the aqueous humor levels of P and Cu were significantly higher than those of controls (p < 0.001, p < 0.001, respectively). However, levels of K and Mg were significantly lower in patients with CMVR (p < 0.001, p < 0.001, respectively). The Spearman correlation test showed that the concentration of IL-8 in the aqueous humor was significantly associated with the aqueous level of Cu (p = 0.009, r = 0.646) and Se (p = 0.031, r = 0.558). In addition, the concentration of CMV DNA load in the aqueous humor was significantly associated with the aqueous level of Ca (p = 0.027, r = −0.568), Mn (p = 0.020, r = 0.593), and Cu (p = 0.043, r = 0.527). Conclusions Our preliminary results demonstrated that the abnormal aqueous levels of trace elements (P and Cu) in CMVR patients. Thus, the roles of trace element changes in the development of CMVR and the influence of intraocular trace element for the prognosis of CMVR warrant further investigations.

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Section: Discussionsupporting

confidence: 62%

Section: Treatment Of Cytomegalovirus Retinitismentioning

confidence: 99%

Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis

Zhou

Wang

et al. 2019

Eye

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“…Measurement of intraocular interleukin-8 levels can indicate the degree of intraocular inflammation during cytomegalovirus retinitis and may be a marker of disease recovery when assessing treatment outcome. 17 – 20 …”

Section: Discussionmentioning

confidence: 99%

Vitritis and retinal vasculitis caused by pseudorabies virus

Ying

Cheng

et al. 2021

J Int Med Res

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Pseudorabies virus (PRV) is a herpesvirus of swine. PRV is also called suid herpesvirus 1 and is a member of the Alphaherpesvirinae subfamily within the family Herpesviridae. The number of PRV cases worldwide is small, but in susceptible individuals, infection with this virus has a poor prognosis. Therefore, it is urgent to improve our understanding of this disease in clinical practice to avoid misdiagnosis and to identify optimal treatments. We report a patient with PRV infection who was admitted to hospital with viral encephalitis and subsequently developed intraocular infection. Because to the lack of relevant clinical experience in the treatment of this disease, we carried out experimental treatment with good therapeutic effect. This case provides a basis for clinical diagnosis and treatment of patients with PRV.

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“…The concentration of interleukin 1β, 6, 8, 10, 12p (IL-1β, IL-6, IL-8, IL-10, IL-12p), TNF-α and vascular endothelial growth factor (VEGF) were measured by cytometric bead array which is a method of capturing a soluble analyte or set of analytes with beads of known size and fluorescence, making it possible to detect analytes using flow cytometry. The detailed technique has been described previously [ 22 , 23 ]. The selection of the cytokines examined in the study was based on their potential importance in the intraocular neovascular or edematous diseases and on the availability of examination kits to measure all them together in a single aqueous humour sample.…”

Section: Methodsmentioning

confidence: 99%

Intracameral Interleukin 1β, 6, 8, 10, 12p, Tumor Necrosis Factor α and Vascular Endothelial Growth Factor and Axial Length in Patients with Cataract

et al. 2015

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ObjectiveTo assess associations between the aqueous humour concentration of interleukin IL-1β, IL-6, IL-8, IL-10 and IL-12p, tumor necrosis factor α (TNF-α) and vascular endothelial growth factor (VEGF) and axial length in eyes with cataract.MethodsThe hospital-based investigation included patients who underwent cataract surgery between March 2014 and April 2014. Using aqueous humour collected at the start of cataract surgery, the interleukins IL-1β, IL-6, IL-8, IL-10 and IL-12p, TNF-α and VEGF were examined using a cytometric bead array. Axial length was determined by partial coherence laser interferometry (IOL Master).ResultsThe study included 33 patients with cataract (33 eyes) with a mean age of 69.2±10.8 years (range:50–87 years) and a mean axial length of 24.7±1.9 mm (range:22.6–31.5 mm). Lower aqueous concentration of VEGF was significantly associated with longer axial length (VEGF concentration (pg/mL) = -5.12 x Axial Length (mm) + 163; correlation coefficient r = -0.41; P<0.001) and more myopic refractive error (VEGF concentration (pg/mL) = 1.27xspherical equivalent (diopters)+44.8; r = 0.383; P = 0.002). The aqueous concentrations of all other substances were not significantly (all P>0.10) associated with axial length or refractive error.ConclusionsHigher intravitreal concentrations of VEGF were measured in eyes with a longer axial length, while the intraocular concentrations of IL-1β, IL-6, IL-8, IL-10, IL-12p and TNF-α were not correlated with axial length. The lower concentration of VEGF in axially elongated eyes may be one of the reasons for the lower prevalence of age-related macular degeneration and diabetic retinopathy in myopic eyes.

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Continued Decline of Aqueous Interleukin-8 After Multiple Intravitreal Injections of Ganciclovir for Cytomegalovirus Retinitis

Cited by 14 publications

References 29 publications

Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis

Abnormal levels of aqueous humor trace elements in patients with cytomegalovirus retinitis

Vitritis and retinal vasculitis caused by pseudorabies virus

Intracameral Interleukin 1β, 6, 8, 10, 12p, Tumor Necrosis Factor α and Vascular Endothelial Growth Factor and Axial Length in Patients with Cataract

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