Contingent negative variation in subjects at risk for migraine without aura

Siniatchkin, Michael; Kropp, Peter; Gerber, Wolf‐Dieter

doi:10.1016/s0304-3959(01)00350-5

Cited by 43 publications

(56 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found that both topiramate and levetiracetam were efficacious, with respect to placebo, in reducing headache frequency to almost 50% of the basal one. In basal conditions, the loss of CNV habituation and the hypersynchronization of alpha rhythm under repetitive flash stimulation were confirmed in this migraine series compared with controls [Siniatchkin et al, 2001;Angelini et al, 2004]. The clinical efficacy of both AEDs was correlated significantly with their normalizing effect on CNV habituation (see Fig.…”

Section: Recent Evidence About the Neurophysiologic Effects Of Aed Insupporting

confidence: 67%

“…Multi-modal evoked potentials have shown this defect in habituation [Ambrosini et al, 2003], including those specifically evoked by nociceptive fiber stimulation [Valeriani et al, 2003;. One of the most reliable indicators of migraine predisposition is the increased amplitude of an event-related potential, the contingent negative variation (CNV), caused by reduced habituation [Schoenen and Timsit-Berthier, 1993]: the CNV amplitude and habituation normalize before an attack [Kropp and Gerber, 1998] and its abnormal pattern appears to be a marker of genetic susceptibility for migraine [Siniatchkin et al, 2001.…”

Section: Neurophysiologic Patterns In Migrainementioning

confidence: 99%

See 1 more Smart Citation

Effects of antiepileptic drugs on neurophysiologic abnormalities subtending migraine

Tommaso

2007

Drug Development Research

View full text Add to dashboard Cite

Recent theories about migraine pathogenesis have outlined migraine as a brain disorder. Migraine can be considered an aberrant physiological state with a low threshold for intermittent neuronal excitability. Neurophysiologic findings in migraine emphasized the presence of abnormal neuronal function during the asymptomatic phase, predisposing to attack occurrence, the main patterns being the loss of habituation of evoked and event related potentials and the hypersynchronization of electroencephalographic (EEG) activity. These studies confirmed the need of preventive agents able to act on neuronal excitability, with growing evidence in favor of the clinical efficacy of anti-epileptic drugs (AED), though electrophysiological evidence supporting migraine as a state of neuronal hypoexcitability rendered the rationale of their use and their fundamental action mechanism in preventing migraine rather questionable. In the last years, many studies reported the efficacy of other preventive agents than AED, such as -blockers, in reversing neurophysiologic abnormalities of migraine, while reducing headache frequency. Our recent results showed a normalizing effects of levetiracetam and topiramate vs. placebo on the dishabituation pattern of the contingent negative variation (CNV) and the efficacy of levetiracetam vs. both topiramate and placebo in reversing the hypersynchronization of alpha rhythm under flash stimulation. All these effects concurred with the clinical efficacy on migraine frequency, and confirmed the action of AED on the basal mechanisms of migraine. Considering our and previous results, migraine may be considered as a state of ''altered'' excitability, where the AED are modulating agents able to reverse the electrophysiological patterns predisposing to the attack occurrence. The challenge for the future may be the identification of subgroups of migraine patients with pronounced expression of some neurophysiologic indexes of migraine predisposition, e.g., hypersynchronization, which may optimize the choice of the preventive agent. Drug Dev Res 68: 369-375, 2007. r 2007

show abstract

Section: Recent Evidence About the Neurophysiologic Effects Of Aed Insupporting

confidence: 67%

Section: Neurophysiologic Patterns In Migrainementioning

confidence: 99%

Effects of antiepileptic drugs on neurophysiologic abnormalities subtending migraine

Tommaso

2007

Drug Development Research

View full text Add to dashboard Cite

show abstract

“…In migrainous child-parent pairs, habituation of evoked potentials has a clear familial pattern. 66,71 Moreover, in asympto matic individuals who have a first degree relative with migraine, and are thus at risk of developing migraine during their lifetime, cortical evoked potentials 79 and nociceptive blink reflexes 86 (nBRs, discussed under processing of noxious stimuli below) showed amplitude and habituation abnormalities similar to those found interictally in people with migraine.…”

Section: Possible Mechanisms Of Habituationmentioning

confidence: 92%

“…For instance, cortical responsivity is cyclic in individuals with migraine, 71 and varies in parallel with changes in platelet serotonin content. 73 The period icity of neurophysiological brain activity might also be related to psychophysical, genetic 66,79 or metabolic factors, 80 or to the biorhythms of hypothalamic activity. 81 Migraine periodicity might thus be the result of several inter acting biological cycles.…”

Section: Episodic Migrainementioning

confidence: 99%

Altered processing of sensory stimuli in patients with migraine

et al. 2014

View full text Add to dashboard Cite

| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

show abstract

“…Disease duration also had an effect on CNV abnormalities in migraineurs [88]. A strong familial influence on CNV parameters was reported by Siniatchkin et al [89], who found abnormalities not only in migraineurs but also in healthy subjects with a positive family history for migraine [90]. The sensitivity of CNV to different prophylactic agents used in migraine and the relative specificity of the difference between headache forms suggest that CNV is a useful method for studying headaches [91].…”

mentioning

confidence: 92%

P300 and contingent negative variation in migraine

2004

View full text Add to dashboard Cite

The event-related potential (ERP) component P300 is considered a cognitive neuroelectrical indicator of central nervous system activity [1] involved with the processing of new information when attention is engaged to update memory representations [2]. P300 latency can be regarded as a measure of the relative timing of the stimulus evaluation process, indicating an upper limit on categorization and stimulus evaluation time [3], or the time taken to allocate resources and engage memory updating [4]. P300 amplitude is held to index attentional resource allocation when memory updating is engaged [2]. The P300 component in many event-related brain potential (ERP) studies is obtained using the so-called odd-ball paradigm, in which two stimuli are presented in random order, with one occurring more frequently than the other [5]. The subject is required to discriminate the infrequent or rare stimulus ("target stimulus") from the frequent or standard stimulus ("nontarget") by noting the occurrence of the target -typically by pressing a button or mental counting [6, 7]. A modification of the oddball paradigm has been developed in which infrequent-nontarget stimuli are inserted into the sequence of target and standard stimuli. When "novel" stimuli (e.g., dog barks, color forms, etc.) are presented as the infrequent nontargets in the series of more "typical" targets and standard stimuli (e.g., tones, letters of the alphabet, etc.), a P300 component that is large over the frontal/central areas is produced. This component has been dubbed the "P3a," whereas the infrequent-target stimulus elicits a parietal maximum P300 or "P3b" [8, 9]. Because this novel P300 exhibits an anterior/central scalp distribution, short peak latency, and rapid habituation, it has been interpreted as reflecting frontal lobe function Abstract We reviewed P300 and contingent negative variation (CNV) studies performed in migraine in order to identify their relevance in migraine and the role of neurophysiology in migraine. Publications available to us were completed by a Medline search. There is experimental and clinical evidence for loss of cognitive habituation in migraine which may serve as a specific diagnostic tool; therefore, we reviewed studies on migraine that analyzed habituation and lack of habituation by P300 and CNV, performing short-term habituation (STH) and long-term habituation (LTH). Finally, we described the two components of P300 (a and b) and of CNV (early and late wave) and the two abnormalities reported from the majority of studies on event-related potential in migraine: increased amplitude of average event-related potential and lack of habituation. These abnormalities are especially related to the early component characterizing orienting activity.

show abstract

Contingent negative variation in subjects at risk for migraine without aura

Cited by 43 publications

References 40 publications

Effects of antiepileptic drugs on neurophysiologic abnormalities subtending migraine

Effects of antiepileptic drugs on neurophysiologic abnormalities subtending migraine

Altered processing of sensory stimuli in patients with migraine

P300 and contingent negative variation in migraine

Contact Info

Product

Resources

About