Contingent negative variation for the periodicity of migraine attacks without aura

Tian, Qiang; Xu, Shu; Guo, Yunliang; Jin, Li Yuezhi ALiu; Han, Mimi; Ma, Yan; Hou, Xunyao; Chen, Jian; Luo, Di; Hong, Yan; Nie, Shanjing; Liu, Xueping

doi:10.31083/j.jin.2019.03.193

Cited by 4 publications

(8 citation statements)

References 36 publications

(47 reference statements)

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“…In agreement with other studies using data of a reduced number of electrodes, young children showed only minor frontal negativity during orienting response (Jonkman et al, 2003;Segalowitz & Davies, 2004), i.e., activation of cortical areas related to the supplementary motor area (SMA) and anterior cingulate cortex (ACC) (Flores et al, 2009;Jonkman et al, 2003). The early frontal negativity stabilized during post-pubertal adolescence, reaching strength of activation comparable to adult subjects (Tian et al, 2019;Weisz et al, 2002). Furthermore, we observed a consistent shift in iCNV latencies, with midfrontocentral areas being recruited earlier in older subjects, suggesting a faster processing of the warning stimulus.…”

Section: Maturation Of Orienting Response (Early Contingent Negative ...supporting

confidence: 90%

Mapping Motor Preparation in the Developing Brain: Insights from Contingent Negative Variation and Event-related Mu Rhythm Modulation

Schmidgen,

Heinen,

Konrad

et al. 2024

Preprint

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Introduction: The motor system shows a pronounced development throughout childhood and adolescence. The analysis of the contingent negative variation (CNV) provides valuable insights into various cognitive and motor processes, underlying cortical sources, and their development across the lifespan. Methods: We investigated the maturation of motor preparation, pre-activation, and post-processing in children and adolescents aged 5- to 16- years. EEG Data of 46 healthy right-handed subjects were recorded, using a 64-electrode high-density sensor array. Subjects performed a CNV task with a directional warning cue. To assess age-related developmental differences of cortical activation, analyses of event-related potentials (ERPs), mu-rhythm (de)synchronization, and source analysis were applied. Results: Children showed increased reaction times and committed more errors than adolescent subjects. Motor preparation and post-processing were characterized by a developmental increase of cortical activity related to the supplementary motor area (SMA). Young children showed a pronounced sensory post-processing during orienting response (early CNV) that decreased with age. In contrast to previous research in young adults, adolescent subjects showed no contralateral activation of motor areas during motor preparation (late CNV) yet. Furthermore, there was an observed decline in motor post processing with maturation. Conclusion: The results indicate a prolonged maturation of cortical scalp areas associated with motor control up into late adolescence or early adulthood. With age, the activation of mid-frontocentral regions associated with the SMA becomes more pronounced during motor planning and response evaluation. Qualitatively distinct cortical activation patterns of young subjects suggest immature supplementary-, pre-, and primary motor areas and might be a primary cause for age-related increasing efficiency of motor action control.

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Section: Maturation Of Orienting Response (Early Contingent Negative ...supporting

confidence: 90%

Mapping Motor Preparation in the Developing Brain: Insights from Contingent Negative Variation and Event-related Mu Rhythm Modulation

Schmidgen,

Heinen,

Konrad

et al. 2024

Preprint

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“…On the other hand, only a smaller group of studies described the effects on the lCNV [36,39,59,88]. Finally, the other investigations did not reveal enhanced amplitudes in any of the CNV subcomponents [20,26,62,68]. Indeed, the most recent study in this field, conducted by Tian and colleagues (2019) [26], found no significant differences in the CNV components (eCNV, lCNV or total CNV) between patients with migraine and healthy individuals [26].…”

Section: Cnv Results In Adult Migraine Patientsmentioning

confidence: 92%

“…This finding has been linked to a potential deficit to habituate towards sensory events. By contrast, some investigations conducted in this field failed to observe differences in the CNV habituation between healthy people and migraine [26,45], or such differences arose in association with the intake of some types of medication (it will be explained in more detail later) [42,60,63].…”

Section: Cnv Results In Adult Migraine Patientsmentioning

confidence: 94%

“…Thus, the loss of habituation was clearly observed a few days before the ictal period (peaking the day before), returning to a normal habituation process during and after the migraine attack [23,40]. However, a more recent study conducted by Tian and colleagues (2019) [26] raised some doubts about the existence of CNV changes associated with the cyclic pattern of migraine [26]. They found no differences in any of the sub-components of CNV as a function of the number of days prior to a migraine attack when compared to healthy people.…”

Section: Cnv Results In Adult Migraine Patientsmentioning

confidence: 95%

“…Specifically, event-related potentials (ERPs) have been examined, highlighting that patients exhibit abnormal neural responses that are suggestive of an impairment in the processing of information [11,13,20]. One of the most studied ERP components in migraine has been the Contingent Negative Variation (CNV) [20][21][22][23][24][25][26]. This waveform typically occurs due to the appearance of an expected stimulus (S2), signaled by a previous one (S1) (see Figure 2: CNV during the S1-S2 expectancy paradigm).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children

de Lahoz,

Barjola,

Peláez

et al. 2023

Biomedicines

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Migraine has been considered a chronic neuronal-based pain disorder characterized by the presence of cortical hyperexcitability. The Contingent Negative Variation (CNV) is the most explored electrophysiological index in migraine. However, the findings show inconsistencies regarding its functional significance. To address this, we conducted a review in both adults and children with migraine without aura to gain a deeper understanding of it and to derive clinical implications. The literature search was conducted in the PubMed, SCOPUS and PsycINFO databases until September 2022m and 34 articles were retrieved and considered relevant for further analysis. The main results in adults showed higher CNV amplitudes (with no habituation) in migraine patients. Electrophysiological abnormalities, particularly focused on the early CNV subcomponent (eCNV), were especially prominent a few days before the onset of a migraine attack, normalizing during and after the attack. We also explored various modulatory factors, including pharmacological treatments—CNV amplitude was lower after the intake of drugs targeting neural hyperexcitability—and other factors such as psychological, hormonal or genetic/familial influences on CNV. Although similar patterns were found in children, the evidence is particularly scarce and less consistent, likely due to the brain’s maturation process during childhood. As the first review exploring the relationship between CNV and migraine, this study supports the role of the CNV as a potential neural marker for migraine pathophysiology and the prediction of pain attacks. The importance of further exploring the relationship between this neurophysiological index and childhood migraine is critical for identifying potential therapeutic targets for managing migraine symptoms during its development.

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From preparation to post-processing: Insights into evoked and induced cortical activity during pre-cued motor reactions in children and adolescents

Schmidgen,

Heinen,

Konrad

et al. 2024

NeuroImage

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Contingent negative variation for the periodicity of migraine attacks without aura

Cited by 4 publications

References 36 publications

Mapping Motor Preparation in the Developing Brain: Insights from Contingent Negative Variation and Event-related Mu Rhythm Modulation

Mapping Motor Preparation in the Developing Brain: Insights from Contingent Negative Variation and Event-related Mu Rhythm Modulation

Unveiling the Role of Contingent Negative Variation (CNV) in Migraine: A Review of Electrophysiological Studies in Adults and Children

From preparation to post-processing: Insights into evoked and induced cortical activity during pre-cued motor reactions in children and adolescents

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