Contiguous pattern spreading in patients with Hodgkin's disease

Roth, Stephan; Sack, H.; Havemann, K.; Willers, Reinhart; Kocsis, Béla; Schumacher, Viola

doi:10.1016/s0167-8140(97)00208-9

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…Presence of non contiguous spread of cervical lymphadenopathy to the abdomen was seen in 7 patients. Such non contiguous infradiaphragmatic spread bypassing the mediastinum is rare [15,16]. Hematogenous spread to the spleen and extra-nodal sites is common in the advanced stage of HL [15,16].…”

Section: Discussionmentioning

confidence: 99%

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Pediatric Hodgkin Lymphoma: CT Features at Presentation, on Treatment and its Prognostic Significance

et al. 2011

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Section: Discussionmentioning

confidence: 99%

“…Such non contiguous infradiaphragmatic spread bypassing the mediastinum is rare [15,16]. Hematogenous spread to the spleen and extra-nodal sites is common in the advanced stage of HL [15,16]. Splenic involvement was seen in 25 (35.7%) patients and 21 of these had three or more nodal group involvement.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Hodgkin Lymphoma: CT Features at Presentation, on Treatment and its Prognostic Significance

et al. 2011

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“…Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed Sternberg cells), has a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes (40, 41); however, the factors which regulate the spread of Hodgkin lymphoma cells are poorly understood. Therefore, in order to improve our understanding in this area, we set out to assess S1PR1 expression in two CHL cell lines (KM-H2 and SUP-HD1) and determine the role S1PR1 may play in CHL tumor cell migration.…”

mentioning

confidence: 99%

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration

Kluk

Ryan

Wang

et al. 2013

Laboratory Investigation

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Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed Sternberg cells), has been described to have a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes. Despite the progress made in understanding CHL pathophysiology, the factors which regulate the spread of lymphoma cells in CHL are poorly understood. Sphingosine-1-Phosphate (S1P), a bioactive sphingolipid present at high concentrations in plasma and lymphatic fluid, is known to play a critical role in regulating lymphocyte trafficking mainly through S1PR1. In this study, we explore the role of the S1P-S1PR1 axis in Hodgkin lymphoma cell migration and the expression of S1PR1 in CHL cell lines and clinical cases. We found that S1PR1 is present in the KM-H2 and SUP-HD1 Hodgkin lymphoma cell lines at the mRNA and protein level. In addition, functionally, S1P potently stimulated migration of both cell lines. S1P-induced migration was inhibited by the S1PR1 antagonist, VPC44116 and the S1PR1 functional antagonist, FTY720-P, but was potentiated by the S1PR2 specific antagonist, JTE013. We also determined that S1PR1 induced migration in the KM-H2 and SUP-HD1 cells via the heterotrimeric G protein Gi and the phosphatidylinositol-3-kinase (PI3K) pathway. Immunohistochemical assessment of tissue from CHL samples revealed that a subset of cases (7/57; 12%) show strong, membranous staining for S1PR1 in Hodgkin-Reed Sternberg cells. Altogether our data indicate that S1PR1 is a functional receptor on Hodgkin-Reed Sternberg cells which governs tumor cell migration and is expressed in a subset of CHL cases. Given the availability of S1PR1 antagonists, some of which are used clinically for modulation of the immune system, these results suggest that S1PR1 could be a future therapeutic target in the treatment of those cases of S1PR1-positive, refractory/recurrent CHL.

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“…An apparent exception to this rule is the case of Hodgkin lymphoma, in which contiguous involvement of the supraclavicular nodes and upper mediastinal nodes is well documented, whereas upper paratracheal nodal involvement is not a recognized feature. 24 In conclusion, this study shows that in NPC patients with neck node metastases to the supraclavicular region, contiguous lymphatic spread to the superior mediastinum is improbable. Regarding patient management, no evidence suggests that the radiation coverage for such cases need be extended caudal to the clavicles to include the upper mediastinum.…”

Section: Discussionmentioning

confidence: 65%

“…A few distinct examples of malignancies of the head and neck region are recognized to demonstrate contiguous nodal spread from the neck to the mediastinum with appreciable frequencies, such as thyroid cancer (particularly medullary carcinoma), 21,22 subglottic laryngeal cancer, 23 and Hodgkin lymphoma. 24 A common characteristic of the nodal metastatic pattern of thyroid and subglottic cancers is early involvement of the lymphatics of the upper paratracheal region in the neck, a feature not expressed by NPC. The implication on management is that surgical dissection of the upper mediastinal lymphatics and en-bloc postoperative radiotherapy to include the upper mediastinal lymphatics need be considered in patients with upper paratracheal nodal metastases from medullary carcinoma of thyroid and subglottic laryngeal cancer 25 but not in NPC.…”

Section: Discussionmentioning

confidence: 99%