Context-specific morphine tolerance on the paw-pressure and tail-shock vocalization tests: evidence of associative tolerance without conditioned compensatory responding

Cepeda-Benito, Antonio; Tiffany, Stephen T.; Cox, Lisa Sanderson

doi:10.1007/s002130051077

Cited by 14 publications

(14 citation statements)

References 29 publications

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“…In this research, animals tolerant, either associatively or non-associatively, to fentanyl showed no evidence of tolerance to the analgesic effects of U50,488H. This finding is consistent with a large number of studies in which there has been little or no evidence of conditioned compensatory hyperalgesia in non-drugged animals exposed to stimuli that have been paired with morphine administration (Cepeda-Benito et al 1999). Collectively, these results are inconsistent with the concept of a conditioned tolerance mechanism that is subserved by an activation of a behavioral system that counteracts the direct effects of a drug.…”

Section: Discussionsupporting

confidence: 91%

Associative and non-associative fentanyl tolerance in the rat: evaluation of cross tolerance with mu-and kappa-specific opioids

Carter¹,

Tiffany²,

Conklin³

2000

Psychopharmacology

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The impact of IDI on the development of non-associative and associative fentanyl tolerance is consistent with findings obtained with morphine showing that conditions conducive to the development of non-associative tolerance disrupt the acquisition of associative tolerance. The cross-tolerance data, however, did not parallel previous research examining the cross-tolerance profiles of associative and non-associative morphine tolerance.

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Section: Discussionsupporting

confidence: 91%

Associative and non-associative fentanyl tolerance in the rat: evaluation of cross tolerance with mu-and kappa-specific opioids

Carter¹,

Tiffany²,

Conklin³

2000

Psychopharmacology

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“…Consistent with this suggestion, activity‐dependent changes in GDNF mRNA expression have been reported within the hippocampus (Reeben et al ., 1998; Kokaia et al ., 1999). The findings that GDNF availability regulates both adaptive responses to drugs of abuse and cognitive performance is interesting in the light of results showing that drug addiction has an important associative learning component (Cepeda‐Benito et al ., 1999; Berke & Hyman, 2000).…”

Section: Discussionmentioning

confidence: 99%

Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation

Gerlai¹,

McNamara²,

Choi-Lundberg³

et al. 2001

Eur J of Neuroscience

105

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Exogenous glial cell line-derived neurotrophic factor (GDNF) exhibits potent survival-promoting effects on dopaminergic neurons of the nigrostriatal pathway that is implicated in Parkinson's disease and also protects neurons in forebrain ischemia of animal models. However, a role for endogenous GDNF in brain function has not been established. Although mice homozygous for a targeted deletion of the GDNF gene have been generated, these mice die within hours of birth because of deficits in kidney morphogenesis, and, thus, the effect of the absence of GDNF on brain function could not be studied. Herein, we sought to determine whether adult mice, heterozygous for a GDNF mutation on two different genetic backgrounds, demonstrate alterations in the nigrostriatal dopaminergic system or in cognitive function. While both neurochemical and behavioural measures suggested that reduction of GDNF gene expression in the mutant mice does not alter the nigrostriatal dopaminergic system, it led to a significant and selective impairment of performance in the spatial version of the Morris water maze. A standard panel of blood chemistry tests and basic pathological analyses did not reveal alterations in the mutants that could account for the observed performance deficit. These results suggest that endogenous GDNF may not be critical for the development and functioning of the nigrostriatal dopaminergic system but it plays an important role in cognitive abilities.

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“…As a result, changes in that stimulus disrupt habituation and restore responsiveness to the stimulus (Peeke, 1984;Peeke & Veno, 1973;Swithers & Hall, 1994;Whitlow, 1975). Many studies have reported that changing the experimental context disrupts tolerance to a drug (e.g., Adams, Yeh, Woods, & Mitchell, 1969;Cepeda-Benito et al, 1999;Cepeda-Benito & Tiffany, 1996;Siegel, 1975Siegel, , 1977; but see also Pinel & Puttaswamaiah, 1985). These studies may provide evidence for stimulus specificity if it is assumed that the context is part of the stimulus to which the participant habituates.…”

Section: Stimulus Specificity (Characteristic 2 Table 1)mentioning

confidence: 99%

Regulation of Drug Taking by Sensitization and Habituation.

McSweeney

Murphy

Kowal

2005

Experimental and Clinical Psychopharmacology

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The authors argue that drug taking is an operant behavior that is reinforced by the drug itself. The effectiveness of a drug as a reinforcer is modulated by sensitization and habituation to the drug as it is consumed. According to this model, drug taking stops when habituation reduces the ability of the drug to reinforce its own consumption. Drug taking resumes when spontaneous recovery restores the effectiveness of the drug as a reinforcer. This parsimonious model provides a framework for understanding many findings in the drug literature, including acute and chronic tolerance, the effect of deprivation on consumption, the contextual specificity of tolerance, polydrug abuse, cross-sensitization between stress and drugs, behavioral sensitization, priming, and reinstatement. Although this model cannot explain all aspects of drug taking (e.g., the effect of cognitive manipulations), it has many implications for understanding and controlling human drug consumption and addiction.

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Context-specific morphine tolerance on the paw-pressure and tail-shock vocalization tests: evidence of associative tolerance without conditioned compensatory responding

Abstract: The data indicated that, although Pavlovian processes can play a major role in tolerance acquisition, there was little support for the thesis that the conditioned tolerance response is a behavioral effect that is opposite in direction to the direct effects of the drug.

Cited by 14 publications

References 29 publications

Associative and non-associative fentanyl tolerance in the rat: evaluation of cross tolerance with mu-and kappa-specific opioids

Associative and non-associative fentanyl tolerance in the rat: evaluation of cross tolerance with mu-and kappa-specific opioids

Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation

Regulation of Drug Taking by Sensitization and Habituation.

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