Context-dependent efficacy of a counter-conditioning strategy with atypical neuroleptic drugs in mice previously sensitized to cocaine

Oliveira-Lima, A.J.; Marinho, E.A.V.; Santos-Baldaia, Renan; Hollais, A.W.; Baldaia, MA; Talhati, F.; Ribeiro, LT; Wuo-Silva, Raphael; Berro, Laís F.; Frussa‐Filho, Roberto

doi:10.1016/j.pnpbp.2016.10.004

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…Regarding cocaine locomotor sensitization, our results show that the administration of MIR, PIN, FLX, RIS, TRZ, ZPR, OND, or PRZ in the previously described dose ranges generated a significant attenuation of cocaine locomotor sensitization. The results are consistent with previous results, which showed that, at the dose mentioned above, MIR [ 50 , 53 ], FLX [ 71 , 74 ], RIS [ 56 ], ZPR [ 75 , 76 ], OND [ 64 , 77 ], and PRZ [ [78] , [79] , [80] ] reduce hyperactivity induced by COC; decrease cocaine self-administration and attenuate the induction and expression of cocaine sensitization.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study

Barbosa-Méndez,

Salazar-Juárez

2024

Heliyon

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Section: Discussionsupporting

confidence: 93%

Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study

Barbosa-Méndez,

Salazar-Juárez

2024

Heliyon

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“… 36 All this would render paliperidone suitable for treating SUD of NMDA inhibiting dissociative agents, and in fact, it was shown to suppress ketamine consumption and psychosis in a 34-year-old man. 37 Also, aripiprazole was shown to counteract behavioral effects of not only the NMDA antagonists dizocilpine 38 – 40 and phencyclidine 41 in rodents but also those of cocaine 42 – 44 and amphetamine, 45 – 47 thus rendering it suitable for a wide range of SUDs.…”

Section: Introductionmentioning

confidence: 99%

Head-to-head comparison of 1-year aripiprazole long-acting injectable (LAI) versus paliperidone LAI in comorbid psychosis and substance use disorder: impact on clinical status, substance craving, and quality of life

Cuomo¹,

Kotzalidis²,

Persis³

et al. 2018

NDT

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BackgroundTo overcome nonadherence in patients with psychosis switch to long-acting injectable (LAI) antipsychotic formulations is adopted. Most oral versus LAI comparisons showed similar antipsychotic responses. Psychoses often overlap with substance use disorder (SUD). Head-to-head LAI comparisons have hitherto focused only on non-comorbid populations.ObjectiveThe objective of this study was to compare two LAIs, administered for 12 months, in initially hospitalized patients with psychosis comorbid with SUD in their clinical and quality of life (QoL) outcomes.Patients and methodsInpatients were recruited during 2016 and switched randomly to 400 mg intramuscular aripiprazole monohydrate (AM) (N=50) or to 100 mg intramuscular paliperidone palmitate (PP) once-monthly (N=51); patients were discharged and followed up for 12 months. Patients were rated at baseline and after 1 year through the Clinical Global Impression scale – severity (CGIs), substance craving intensity was rated through a visual analog scale for substance craving, and QoL through the World Health Organization (WHOQOL-BREF) scale. We addressed confounders with backward stepwise logistic regression and three-way analysis of variance.ResultsPP were older and had more cases of schizophrenia spectrum and less bipolar disorders than AM, but AM had a stronger craving for substances at baseline. Both LAIs were associated with significant improvements in all outcomes, with AM displaying stronger effect sizes than PP. The two groups did not differ on baseline WHOQOL-BREF scores in any domain, but at the 1-year follow-up, AM fared better on all domains. The two groups did not differ in final severity, but PP scored higher than AM in craving at the 1-year endpoint.Limitation: The CGIs is not a refined tool for severity and the substance craving may be subject to recall bias.Conclusion1-year AM and PP was followed by improved clinical status and QoL and reduced substance craving in a population with psychosis and SUD comorbidity. AM, compared to PP, improved craving and QoL at the 1-year follow-up.

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Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice

Asth

Iglesias

Brianis

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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Context-dependent efficacy of a counter-conditioning strategy with atypical neuroleptic drugs in mice previously sensitized to cocaine

Cited by 6 publications

References 41 publications

Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study

Evaluation of multitarget drugs on the expression of cocaine-induced locomotor sensitization in male rats: A comparative study

Head-to-head comparison of 1-year aripiprazole long-acting injectable (LAI) versus paliperidone LAI in comorbid psychosis and substance use disorder: impact on clinical status, substance craving, and quality of life

Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice

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