Content of the Major Extracellular Matrix Components of the Liver and Lungs in Mice with Chronic BCG-Granulomatosis Treated with Liposome-Encapsulated Dextrazide

Kim, L. B.; Putyatina, A. N.; Russkikh, G. S.; Shkurupy, V. A.

doi:10.1007/s10517-021-05086-7

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…In another mouse model, intraperitoneal administration of LEDZ (4 months after infection with BCG vaccine, LEDZ administration for 2 months) suppressed the expression of MMP-9 mRNA and type III collagen α1 chain in the lungs, which indicates inhibition of fibroblast differentiation into myofibroblasts [129]. Inhalations of LEDZ in this experiment had no effect on the studied indicators.…”

Section: Introduction Of Ledz At the Stage Of Stabilization Of Bcg-in...mentioning

confidence: 59%

Mechanism of lungs fibrosis in mycobacterial infection

Kim,

Putyatina

2023

Exploration of Medicine

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Lung tuberculosis (TB) remains a heavy burden on public health worldwide. This review discusses mainly the mechanisms of the development of pulmonary fibrosis in an experimental TB model in mice. The involvement of individual components of the extracellular matrix, the activity of matrix metalloproteinases, and the role of their tissue inhibitors in the fibrosis development. The current TB therapy activates fibrosis along with anti-mycobacterial action. The paper describes the authors’ results of experimental use of the liposome-encapsulated dextrazid (LЕDZ) combined with isoniazid (INH) which has both antifibrotic and anti-mycobacterial effects to be considered for future treatment.

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Section: Introduction Of Ledz At the Stage Of Stabilization Of Bcg-in...mentioning

confidence: 59%

Mechanism of lungs fibrosis in mycobacterial infection

Kim,

Putyatina

2023

Exploration of Medicine

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Assessing the collagen metabolism in experimental BCG-induced tuberculous inflammation

Putyatina,

Kim,

Russkikh

2024

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

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The paper presents the study results of the organs of mice without (control group) and with BCG-induced granulomatosis. The contents of hydroxyproline (Hyp) fractions (free, peptide-bound, and protein-bound) were measured in the liver, lungs, and spleen by our alkaline hydrolysis method. In mice with BCG-induced granulomatosis, an increased content of Hyp fractions, reflecting the collagen synthesis, was observed, while the content of free Hyp, characterizing the collagen degradation, did not differ from similar indicators of the control group. The analysis of the ratios of individual Hyp fractions showed a different fibrosis degree in the organs. It was high in the lungs, moderate in the liver and weak in the spleen, thus indicating the organ-specific fibrogenesis in tuberculous infection.

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Content of the Major Extracellular Matrix Components of the Liver and Lungs in Mice with Chronic BCG-Granulomatosis Treated with Liposome-Encapsulated Dextrazide

Cited by 2 publications

References 11 publications

Mechanism of lungs fibrosis in mycobacterial infection

Mechanism of lungs fibrosis in mycobacterial infection

Assessing the collagen metabolism in experimental BCG-induced tuberculous inflammation

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