Content of certain cytokines and chemokines in blood ofpatients with chronic hepatitis B in the early stages of liver fibrosis

Batsunov, Oleg K.; Арсентьева, Н. А.; Любимова, Н. Е.; Эсауленко, Е. В.; Семенов, А В; Тотолян, Арег А.

doi:10.15789/1563-0625-coc-1964

Med. immunol.

2020

DOI: 10.15789/1563-0625-coc-1964

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Content of certain cytokines and chemokines in blood ofpatients with chronic hepatitis B in the early stages of liver fibrosis

Oleg K. Batsunov¹,

Н. А. Арсентьева²,

Н. Е. Любимова³

et al.

Abstract: Batsunov O.K. et al. Бацунов О.К. и др. Medical Immunology (Russia)/Meditsinskaya Immunologiya Медицинская Иммунология содержанием TNFα и хемокинов CCL2/MCP-1 и CCL8/MCP-2, чего не наблюдается в контрольной группе. В то же время в контрольной группе обнаружена корреляция между содержанием TNFα и хемокина CXCL9/MIG, что не выявлено в группе больных. Для обеих групп обнаружена корреляция между содержанием хемокинов CXCL9/MIG и CXCL10/IP-10. На основании данных исследования разработан алгоритм, который позволяет … Show more

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2023

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Cytokine Blood Profile in Patients With Diffuse Liver Disease Combined With Epstein-Barr Virus and Secondary Immunodeficiency

Perfil'eva,

Sotskaya

2023

Ulyanovsk Medico-biological Journal

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The aim of the paper is to study cytokine blood profile (CBP) in patients with chronic diffuse liver disease (DLD) associated with the Epstein-Barr virus (EBV) and secondary immunodeficiency (SID), using a combination of drugs with hepatoprotective (arginine glutamate) and immunomodulatory effects (aminodihydrophthalazinedione sodium). Materials and Methods. The authors examined 66 patients, aged 19–45, with DLD, associated with EBV and SID. The main group consisted of 34 patients, whereas the experimental group enrolled 32 patients. When developing a therapy program for such patients the authors paid attention to a combination of drugs with hepatoprotective (arginine glutamate) and immunomodulatory effects (aminodihydrophthalazinedione sodium). Patients from the main group, in addition to conventional therapy, received combined therapy with the above-mentioned drugs. Results. All patients were under dynamic observation. Before treatment, patients of both groups had similar CBP imbalance, which was characterized by an increase in pro-inflammatory cytokines – TNF-α and IL-1β and a moderate increase in anti-inflammatory IL-4 and IL-10. After treatment, patients of the main group, who received aminodihydrophthalazinedione sodium and arginine glutamate, demonstrated normalization in CBP parameters, while the parameters of the patients from the comparison group exceeded the norm. Conclusion. Combined therapy in the complex treatment of patients with chronic DLD, combined with EBV and SID, contributes to the normalization of the studied CBP parameters (TNF-α, IL-1β, IL-4, IL-10).

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Cytokine Blood Profile in Patients With Diffuse Liver Disease Combined With Epstein-Barr Virus and Secondary Immunodeficiency

Perfil'eva,

Sotskaya

2023

Ulyanovsk Medico-biological Journal

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show abstract

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Content of certain cytokines and chemokines in blood ofpatients with chronic hepatitis B in the early stages of liver fibrosis

Cited by 1 publication

References 8 publications

Cytokine Blood Profile in Patients With Diffuse Liver Disease Combined With Epstein-Barr Virus and Secondary Immunodeficiency

Cytokine Blood Profile in Patients With Diffuse Liver Disease Combined With Epstein-Barr Virus and Secondary Immunodeficiency

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