Contemporary Systemic Therapies in Urothelial Carcinoma

Zhang, JJ H.; Starr, Savannah; Chamie, Karim

doi:10.1016/j.urology.2023.01.007

Cited by 3 publications

(1 citation statement)

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“…Multimodal therapy (MMT) has exploratory potential and has gradually become the preferred treatment for advanced urogenital tumors [ 173 ]. Current studies have shown that immune-based combination therapies have definite efficacy in first- or second-line treatment of aUC, especially in combination with ADCs [ 174 ]. As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

The combination of immune checkpoint inhibitors and antibody-drug conjugates in the treatment of urogenital tumors: a review insights from phase 2 and 3 studies

Yu,

Zhu,

You

et al. 2024

Cell Death Dis

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With the high incidence of urogenital tumors worldwide, urinary system tumors are among the top 10 most common tumors in men, with prostate cancer ranking first and bladder cancer fourth. Patients with resistant urogenital tumors often have poor prognosis. In recent years, researchers have discovered numerous specific cancer antigens, which has led to the development of several new anti-cancer drugs. Using protein analysis techniques, researchers developed immune checkpoint inhibitors (ICIs) and antibody-conjugated drugs (ADCs) for the treatment of advanced urogenital tumors. However, tumor resistance often leads to the failure of monotherapy. Therefore, clinical trials of the combination of ICIs and ADCs have been carried out in numerous centers around the world. This article reviewed phase 2 and 3 clinical studies of ICIs, ADCs, and their combination in the treatment of urogenital tumors to highlight safe and effective methods for selecting individualized therapeutic strategies for patients. ICIs activate the immune system, whereas ADCs link monoclonal antibodies to toxins, which can achieve a synergistic effect when the two drugs are combined. This synergistic effect provides multiple advantages for the treatment of urogenital tumors.

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Section: Discussionmentioning

confidence: 99%