Contemporary synthetic strategies in organofluorine chemistry
Abstract:At this stage, I've edited the manuscript for brevity and clarity. Queries are meant to draw your attention to edits, inconsistencies or issues that are unclear. If we just ask you to confirm edits are correct, a simple yes/ok between the brackets will do [Au:OK? Is this what you meant? Edits OK? yes]. If questions are asked, please rephrase/update the manuscript text when addressing queries, so that the message is conveyed to the reader (please do not just type your answer to our query unless it is unclear).A… Show more
“…Owing to the unique properties of the fluorine element, the introduction of one or a few fluorine atoms to biologically interesting molecules can significantly change their physical, chemical and biological properties. 1 Hence, different classes of fluorine-containing organic compounds have been developed and used as pharmaceuticals and agrochemicals. 2 Fluorinated organic compounds can be achieved through fluoroalkylation, using which the construction of trifluoromethyl compounds 3 and difluoroalkyl compounds 4 has been extensively developed over the past decade.…”
A novel copper-catalyzed three-component reaction of monofluoroalkylation agents, alkenes and TMSCN is described. In addition, alkynes could also be compatible with the reaction system to obtain three component products firstly...
“…Owing to the unique properties of the fluorine element, the introduction of one or a few fluorine atoms to biologically interesting molecules can significantly change their physical, chemical and biological properties. 1 Hence, different classes of fluorine-containing organic compounds have been developed and used as pharmaceuticals and agrochemicals. 2 Fluorinated organic compounds can be achieved through fluoroalkylation, using which the construction of trifluoromethyl compounds 3 and difluoroalkyl compounds 4 has been extensively developed over the past decade.…”
A novel copper-catalyzed three-component reaction of monofluoroalkylation agents, alkenes and TMSCN is described. In addition, alkynes could also be compatible with the reaction system to obtain three component products firstly...
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