With the advancement of globalization and the deepening of the interlock between cities worldwide, the research on urban culture and creative development should be expanded from single city scale to regional and urban agglomeration scale, and creative clusters will become an important spatial scale to break the bottleneck of urban development in the future. In Europe, cities such as London, Paris and Milan have developed creative industries and built creative clusters earlier and then gradually become global creative centers. However, there are few studies on the development of their creative industries from a regional perspective. This research uses multi-source data, within the scope selected based on comprehensive standards, to analysis regional development characteristics of creative industries in Milan, creative clusters formed with Milan as its core and influencing factors of the development. Through the study of a global creative center from regional perspective, references for emerging creative cities and cities that need industrial transformation can be concluded.