Background: Popliteal artery injuries (PAIs) are one of the most severe peripheral vascular damages that may lead to movement impairment or amputation. This study aimed to compare the repair results of PAIs due to blunt and penetrating trauma in patients referred to the Vascular Surgery Center in the southwest of Iran. Methods: In this case-control study that conducted on patients with vascular trauma referred to the southwest trauma center of Iran in 2020; case group included patients with blunt trauma and control group compromised patients with penetrating trauma. The sampling method was census. The data collection tool was a checklist containing demographic information, medical information, vascular information, Functional Independence Measure (FIM) Score, and Mangled Extremity Severity Score (MESS). The chi-square test, Fisher exact test, and independent t test were used for comparison of categorical and quantitative data between case and control groups. Statistical analyses were conducted using SPSS version 24. Significance level considered p-value less than 0.05. Results: In this study from 92 participants, 63.1% of them (58 people) had blunt trauma (case group); The mean age of participants in the case group was 45.37 - 9.14 and in the control group was 49.43 - 10.65. 64.7 % of participants in the case group and 67.2 in the control group were male. The mean GCS of participants in the case group was 10.80 - 1.30 and in the control group was 11.72 - 0.70. 10.6% of participants needed limb fasciotomy (1.7% in the case group and 26.3% in the control group). The amputation rate was 12% in the case group and 8.8% in the control group. There was a significant difference between the two groups in terms of organ fasciotomy (P = 0.035), type of PAI (P = 0.018), and fracture (P = 0.007). MESS (P < 0.001), FIM Score (P < 0.001), time of discharge (P < 0.001), and arterial condition (P < 0.001). Conclusions: The results showed that the complications of penetrating PAI included organ fasciotomy (type of fracture, MESS, FIM Score, time of discharge, and arterial condition) in the southwest of Iran and were significantly more than the blunt type. More studies are needed with a larger sample size and extended duration. Keywords: Blunt Trauma, Penetrating Trauma, Popliteal Artery, Vascular Surgery