COnteMporary Modalities In Treatment of Heart Failure: a report from the COMMIT-HF registry

Abstract

A b s t r a c tBackground and aim: Heart failure (HF) has become a global health problem and is a significant burden for health-care systems worldwide. It is reported as the reason for 1-4% of all hospital admissions in developed countries. The prognosis in HF remains unfavourable. Having at our disposal a large group of patients with systolic HF at a high-volume reference cardiovascular centre with the possibility to implement complete diagnostics and therapy we decided to analyse the clinical data, administered therapies, and prognosis in HF patients. Methods:The COMMIT-HF is a single-centre observational study that is underway in the Third Chair and Department of Cardiology of the Silesian Centre for Heart Diseases in Zabrze. The study population is a cohort of adult HF patients with left ventricular ejection fraction (LVEF) ≤ 35%. Patients with acute coronary syndromes are excluded from the analysis. Complete patient demographics: medical history, hospitalisation data (diagnostic and therapeutic), and in-hospital results are collected. Twelve-month follow-up is based on the information acquired from the national health-care provider. Results:As of 31 December 2013 a group of 1798 patients have been enrolled (mean age 60.9 ± 12.8 years, 20.3% of subjects female, mean LVEF 26.06 ± 6.09, ischaemic aetiology 64.5%, atrial fibrillation 33.2%, diabetes mellitus 41.2%, chronic kidney disease stage ≥ III 29%). A significant proportion of patients underwent invasive procedures (ICD/CRT-D implantation 61.1%, coronary angiography 56.2%, PCI 19.6%, CABG 5.1%, heart transplantation qualification 5.5%, IABP 2.5%). All-cause 12-month morality was 12.5%. HF-related rehospitalisation rate was 28.9%. Conclusions:The COMMIT-HF study will provide valuable information on the HF patient population. Initial analyses show that in this difficult patient population satisfactory long-term results can be achieved.

Long-term clinical outcomes after placement of an implantable cardioverter-defibrillator: does the etiology of heart failure matter?

“…The baseline clinical characteristics of the study groups are presented in TABLE 1. Patients in the ICM group were more often male than in the NICM group (85.6% vs 74%; P <0.001) and were older (mean [SD], 64 [10] vs 53 [13]; P <0.001). Patients with ICM more often had diabetes mellitus (42.1% vs 32.6; to apply ICD therapy or whether we should rethink guidelines with regard to this question.…”

“…The COMMIT -HF (Contemporary Modalities In Treatment of Heart Failure) registry is a prospective single -center observational registry (ClinicalTrials.gov identifier, NCT02536443) which was described elsewhere. 10 Data collection was based on the Polish healthcare provider registry. The study protocol was approved by an appropriate institutional review board and ethics committee; patient written consent was not required.…”

Prognostic value of red blood cell distribution width in patients with left ventricular systolic dysfunction: Insights from the COMMIT-HF registry

“…The COMMIT-HF registry included patients with LVEF of ≤ 35% without ACS [13,14]. Baseline characteristics and in-hospital data were recorded on case report forms.…”

Impact of Remote Monitoring on Long‐Term Prognosis in Heart Failure Patients in a Real‐World Cohort: Results From All‐Comers COMMIT‐HF Trial

“…10 Briefly, COMMIT-HF is a single-center, ongoing prospective observational registry (ClinicalTrials.gov, NCT02536443). 10 Briefly, COMMIT-HF is a single-center, ongoing prospective observational registry (ClinicalTrials.gov, NCT02536443).…”

“…The Contemporary Modalities In Treatment of Heart Failure Registry (COMMIT-HF) has been previously described elsewhere. 10 Briefly, COMMIT-HF is a single-center, ongoing prospective observational registry (ClinicalTrials.gov, NCT02536443). Data collection is patient-based and the long-term follow-up is based on registries of national health care providers ensuring completeness of the database.…”