Contemporary Management of Regional Nodes in Penile Cancer—Improvement of Survival?

Djajadiningrat, Rosa S.; Graafland, Niels M.; Werkhoven, Erik van; Meinhardt, W.; Bex, Axel; Poel, Henk G. van der; Boven, Hester H. van; Olmos, Renato A. Valdés; Horenblas, Simon

doi:10.1016/j.juro.2013.07.088

Cited by 116 publications

(59 citation statements)

References 25 publications

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“…In the Netherlands, over 60% of all Dutch penile cancer patients are annually treated in our institute [6]. We assessed in this Dutch cohort whether 5-year disease-specific survival (DSS) of penile cancer patients with different BMI stages differed.…”

Section: Introductionmentioning

confidence: 99%

Penile Cancer Stage, Survival and Body Mass Index

Djajadiningrat¹,

Werkhoven²,

Horenblas³

2015

Urol Int

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Objective: The aim of this study was to determine whether a higher body mass index (BMI) in penile cancer patients is associated with more advanced penile cancer stage at the time of treatment and cancer survival. Methods: We evaluated 433 penile cancer patients treated between 2006 and 2012 at our institute and recorded American Joint Committee on Cancer (AJCC) stage, BMI, circumcision, smoking and age. A proportional odds model was used to assess a possible association between BMI and AJCC stage at diagnosis and controlled for circumcision, smoking and age. Five-year disease-specific survival was calculated using the Kaplan-Meier method, with the log-rank test assessing equality of distributions. Results: 433 patients with a mean BMI of 26.8 kg/m² were analyzed. No statistically significant association between BMI and AJCC stage was found (odds ratio 1.01 per 1 kg/m² increase in BMI, 95% confidence interval 0.97-1.05, p = 0.63). Differences in disease-specific survival were not observed based on the different BMI classes. Conclusions: No association between BMI of penile cancer patients and their disease stage at the time of treatment was observed. Thus, BMI at penile cancer treatment does not affect prognosis.

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Section: Introductionmentioning

confidence: 99%

Penile Cancer Stage, Survival and Body Mass Index

Djajadiningrat¹,

Werkhoven²,

Horenblas³

2015

Urol Int

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“…In een analyse door Rosa Djajadiningrat is gekeken of patiënten die in een latere fase zijn behandeld beter af zijn [1]. Bijna 1.000 patiënten met een minimale follow-up van twee jaar werden in vier cohorten van verschillende behandelperioden onderverdeeld.…”

Section: Effecten Van Concentratieunclassified

Behandeling van peniscarcinoom

Horenblas

2017

Tijdschr Urol

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Samenvatting De concentratie van de behandeling van peniskankerpatiënten in het Antoni van Leeuwenhoek heeft zich in een periode van ongeveer 10 jaar voltrokken, zonder bemoeienissen van welke instantie dan ook. Deze ongedwongen verandering in de behandelpraktijk van urologen in Nederland is het resultaat van door collegae erkende expertise, gebaseerd op veelvuldig gepubliceerd en uitgedragen onderzoek. Deze concentratie heeft geresulteerd in: 1) De kwaliteit van de zorg is toegenomen en behoort wereldwijd tot de beste, afgaande op de overlevingscijfers. 2) De concentratie van patiënten heeft de mogelijkheden geschapen om onderzoek te doen naar: a) de effectiviteit van de behandeling, b) de introductie van nieuwe behandelingen en c) onderzoek naar de oorzaak van peniscarcinoom. Daarnaast heeft de concentratie van patiënten bijgedragen aan de wereldwijde discussie over centralisatie. De behandeling van het peniscarcinoom in ons land kan als voorbeeld dienen van hoe concentratie gunstig kan uitpakken voor de kwaliteit van de zorg. Als zodanig kan de behandeling dienen als een voorbeeld voor centralisatie bij andere typen tumoren, indien aan de voorwaarden van algemeen erkende expertise wordt voldaan. The treatment of penis cancerAn example for centralization?Abstract Within a period of 10 years we have witnessed a change in the referral pattern of penis cancer patients. Almost 75% of Dutch penis cancer patients are being referred to the Netherlands Cancer Institute Antoni van Leeuwenhoek. This was not due to a deliberate health policy, but a voluntary change due to recognized expertise based on extensive presentations and publications of the department. This concentration has resulted in: 1) Increase of the quality of care as seen by increased survival figures. 2) The concentration of penis cancer patients in one institute has led to analyses of the results of the various treatments and led to improvements of the treatment worldwide.3) The concentration of patients was also instrumental in the initiation of research into the etiology of penis cancer and quality of life. The treatment of penis cancer in the Netherlands can be exemplary for the effects of centralization, assuming that the conditions for recognized expertise are present.

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“…Sentinel lymph node biopsy (SLNB) offers a wellrecognised alternative to lymph node dissection and is already widely used in melanoma and breast cancer [6,7] . It is also already an accepted part of management in certain urological malignancies such as penile and pelvic malignancy [8][9][10][11][12] . Associated with a lower mortality and morbidity cost than the traditional alternative, it still offers clinicians the opportunity to stage disease and equally importantly, to identify patients in whom tumour resection alone may not be curative [10,13,14] .…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node biopsy in renal malignancy: The past, present and future

Mahesan

Coscione

Ayres

et al. 2016

WJN

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Sentinel lymph node biopsy (SLNB) is now an established technique in penile and pelvic cancers, resulting in a lower mortality and morbidity when compared with the traditional lymph node dissection. In renal cancer however, despite some early successes for the SLNB technique, paucity of data remains a problem, thus lymph node dissection and extended lymph node dissection remain the management of choice in clinically node positive patients, with surveillance of lymph nodes in those who are clinically node negative. SLNB is a rapidly evolving technique and the introduction of new techniques such as near infra-red fluorescence optical imaging agents and positron emission tomography/computed tomography scans, may improve sensitivity. Evidence in support of this has already been recorded in bladder and prostate cancer. Although the lack of large multi-centre studies and issues around false negativity currently prevent its widespread use, with evolving techniques improving accuracy and the support of large-scale studies, SLNB does have the potential to become an integral part of staging in renal malignancy.

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Contemporary Management of Regional Nodes in Penile Cancer—Improvement of Survival?

Cited by 116 publications

References 25 publications

Penile Cancer Stage, Survival and Body Mass Index

Penile Cancer Stage, Survival and Body Mass Index

Behandeling van peniscarcinoom

Sentinel lymph node biopsy in renal malignancy: The past, present and future

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