Contemporary Management of Out-of-hospital Cardiac Arrest in the Cardiac Catheterisation Laboratory: Current Status and Future Directions

Pareek, Nilesh; Kordis, Peter; Webb, Ian; Noč, Marko; MacCarthy, Philip; Byrne, Jonathan

doi:10.15420/icr.2019.3.2

Cited by 17 publications

(17 citation statements)

References 171 publications

(132 reference statements)

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“…The postcardiac arrest phase is a complex synthesis of various processes which in combination with the appropriate management strategies such as therapeutic hypothermia and concomitant drugs such as morphine, alter the response of platelet function to conventional antiplatelet treatment. 62 Because those patients were in need of adequate platelet inhibition and underwent a primary PCI while they were intubated, different small pharmacodynamic studies investigated the role of “crushed” oral potent P2Y 12 inhibitors periprocedurally (patients also received intravenously UFH and aspirin) and concluded that they were correlated with sufficient platelet inhibition. 63 However, the available data of this strategy concerning clinical outcomes are scarce so far.…”

Section: Antithrombotic Therapy During Pcimentioning

confidence: 99%

Periprocedural Antithrombotic Treatment in Complex Percutaneous Coronary Intervention

Vlachakis

Varlamos

Benetou

et al. 2022

Journal of Cardiovascular Pharmacology

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:In recent years, the management of complex lesions in patients undergoing percutaneous coronary intervention (PCI) constitutes a field of high interest and concern for the interventional cardiology. As more and more studies demonstrate the increased hazard of ischemic events in this group of patients, it is of paramount importance for the physicians to choose the optimal periprocedural (pre-PCI, during-PCI and post-PCI) antithrombotic treatment strategies wisely. Evidence regarding the safety and efficacy of current anticoagulation recommendation, the possible beneficial role of the pretreatment with a potent P2Y12 inhibitor in the subgroup of patients with non-ST segment elevation myocardial infarction with complex lesions, and the impact of a more potent P2Y12 inhibitor in individuals with stable coronary artery disease undergoing complex PCI are needed. This will provide and serve as a guide to clinicians to deploy the maximum efficacy of the current choices of antithrombotic therapy, which will lead to an optimal balance between safety and efficacy in this demanding clinical scenario.

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Section: Antithrombotic Therapy During Pcimentioning

confidence: 99%

Periprocedural Antithrombotic Treatment in Complex Percutaneous Coronary Intervention

Vlachakis

Varlamos

Benetou

et al. 2022

Journal of Cardiovascular Pharmacology

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“… 90 , 91 , 92 Also, as a result of possible injuries due to chest compression, intubation, and trauma during the OHCA, these patients are at an increased risk of bleeding. 93 , 94 …”

Section: Therapeutic Interventions In Cardiogenic Shock Requiring Specific Antithrombotic Regimensmentioning

confidence: 99%

“…These mechanisms place OHCA patients at a particularly high risk of acute and subacute stent thrombosis, ranging from 1.4% up to 31% 90–92 . Also, as a result of possible injuries due to chest compression, intubation, and trauma during the OHCA, these patients are at an increased risk of bleeding 93,94 …”

Section: Therapeutic Interventions In Cardiogenic Shock Requiring Spe...mentioning

confidence: 99%

“…[90][91][92] Also, as a result of possible injuries due to chest compression, intubation, and trauma during the OHCA, these patients are at an increased risk of bleeding. 93,94 Approximately 45% of comatose OHCA survivors had an insufficient response to aspirin. 95 The intravenous route is justified not only for initial but also for subsequent aspirin administration because the absorption of enterally administered aspirin remains affected by hypothermia.…”

Section: Targeted Temperature Management and Out-ofhospital Cardiac A...mentioning

confidence: 99%

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Antithrombotic and anticoagulation therapies in cardiogenic shock: a critical review of the published literature

et al. 2021

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Cardiogenic shock (CS) is a complex multifactorial clinical syndrome, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large phenotypic variability in CS, as a result of the diverse aetiologies, pathogenetic mechanisms, haemodynamics, and stages of severity. Although early revascularization remains the most important intervention for CS in settings of acute myocardial infarction, the administration of timely and effective antithrombotic therapy is critical to improving outcomes in these patients. In addition, other clinical settings or non‐acute myocardial infarction aetiologies, associated with high thrombotic risk, may require specific regimens of short‐term or long‐term antithrombotic therapy. In CS, altered tissue perfusion, inflammation, and multi‐organ dysfunction induce unpredictable alterations to antithrombotic drugs' pharmacokinetics and pharmacodynamics. Other interventions used in the management of CS, such as mechanical circulatory support, renal replacement therapies, or targeted temperature management, influence both thrombotic and bleeding risks and may require specific antithrombotic strategies. In order to optimize safety and efficacy of these therapies in CS, antithrombotic management should be more adapted to CS clinical scenario or specific device, with individualized antithrombotic regimens in terms of type of treatment, dose, and duration. In addition, patients with CS require a close and appropriate monitoring of antithrombotic therapies to safely balance the increased risk of bleeding and thrombosis.

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“…Out-of-hospital cardiac arrest (OHCA) didefinisikan sebagai hilangnya kontraktilitas mekanis jantung secara tiba-tiba yang terjadi dalam setting komunitas (Pareek, et al, 2019). OHCA masih menjadi masalah kesehatan global dengan angka kejadian rata-rata 55 per 100.000 orang per tahun (Berdowski, Berg, Tijssen, & Koster, 2010).…”

Section: A Pendahuluanunclassified

Teenager Caderization to Respond to Cardiac Arrest Using Smartphone Application "Be Abystander"

Rachmawati¹,

Wisnasari²,

Wihastuti³

et al. 2021

CJPM

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Out-of-Hospital Cardiac Arrest (OHCA) is considered as a global health problem because of its high incidence and low survival rates. Cardiopulmonary Resuscitation (CPR) performed immediately by a bystander for OHCA patients increases the patients’ survival rate. However, the rate of CPR for OHCA patients remains very low due to the lack of willingness to become a bystander. One way to increase the number of CPR bystanders is by providing training on how to perform CPR. Students is considered to be the best bystander candidate because of their high curiosity and ability to memorize complex objects. This community service aims to increase the survival rates of OHCA patients through the youth cadreization responding to cardiac arrest using the Smartphone Application "Be A Bystander". This community service activity includes providing education about cardiac arrest and CPR, training on CPR with the simulation method (roleplay), and training on CPR using the “Be a Bystander” application. The indicators of the success of this community service are an increase in the knowledge, skills, and willingness of participants to become a bystander. Evaluation showed a significant increase in knowledge (p = 0.000), skills (p = 0.000), and willingness (p = 0.000) of participants before and after programs were carried out. After this community services activity, we hope more students are willing to become a competent bystander.

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Contemporary Management of Out-of-hospital Cardiac Arrest in the Cardiac Catheterisation Laboratory: Current Status and Future Directions

Cited by 17 publications

References 171 publications

Periprocedural Antithrombotic Treatment in Complex Percutaneous Coronary Intervention

Periprocedural Antithrombotic Treatment in Complex Percutaneous Coronary Intervention

Antithrombotic and anticoagulation therapies in cardiogenic shock: a critical review of the published literature

Teenager Caderization to Respond to Cardiac Arrest Using Smartphone Application "Be Abystander"

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