Contemporary Management of Human Immunodeficiency Virus in Pregnancy

Donnelly, Meghan; Davies, Jill

doi:10.1016/j.ogc.2014.08.003

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…[4][5][6][7][8] This issue, however, has rarely been addressed in pregnant women, 9,10 although they represent a particularly vulnerable population, characterized by specific clinical and therapeutic requirements and by an additional risk of pregnancy-related complications. 11 Given the clinical relevance of this issue, we used data from a national study of pregnant women with HIV to analyze the proportion of newly diagnosed pregnant women with advanced disease, the determinants of this occurrence, and its impact on maternal and neonatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

Brief Report

Floridia

Tamburrini

Masuelli

et al. 2015

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Among 469 women with a diagnosis of HIV in pregnancy, 74 (15.8%) presented with less than 200 CD4 cells per cubic millimeter. The only variable significantly associated with this occurrence was African origin (odds ratio: 2.22, 95% confidence intervals: 1.32 to 3.75, P = 0.003). Four women with low CD4 (5.6%), compared with none with higher CD4 counts, had severe AIDS-defining conditions (P < 0.001) during pregnancy or soon after delivery, and one transmitted HIV to the newborn. Early preterm delivery (<32 weeks) was significantly more frequent with low CD4 (6.2% vs. 1.4%, P = 0.015). An earlier access to HIV testing, particularly among immigrants of African origin, can prevent severe HIV-related morbidity.

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