Contemporary early results of late repair of tetralogy of Fallot in children: a single-centre case series

Mottier, Vincent; Prša, Milan

doi:10.4414/smw.2021.20491

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Also, severe obstruction was not found in any of the patients after the surgery. The results of the previous studies for TFTC in the patients who were older than the recommended age, was successful [24,25].…”

Section: Discussionmentioning

confidence: 97%

Short-term outcomes following total correction of tetralogy of fallot in adult patients

Khajali,

Mohammadi,

Toloueitabar

et al. 2023

J Cardiothorac Surg

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Objectives Tetralogy of Fallot (TOF) is a common congenital heart disease which should be corrected. The recommended time for the Tetralogy of Fallot Total Correction (TFTC) surgery is during the infancy for the possible difficulties during the surgery and the related issues. However, sometimes TOF is diagnosed and managed during the adulthood. Methods This study is a descriptive and retrospective one which included all patients who underwent TFTC at the age of 15-year and older in 10 years (between the years 2010 and 2020) to identify short-term (in-hospital mortality, ICU stay, postoperative bleeding, respiratory complications after the surgery such as pulmonary edema, pneumonia, etc.) and one-year (left ventricle ejection fraction (LVEF), right ventricle (RV) ejection fraction, the severity of tricuspid and aortic regurgitation after surgery) outcomes. All data were taken from medical records at Rajaie Cardiovascular Medical and Research Center. Data were analyzed using SPSS 22. Results 94 patients with the mean ± SD age of 26.7 ± 9.6 years were enrolled. Most of them were male (59.6%) (P-value: 0.009). In-hospital mortality in our study were 5.3%. Tricuspid regurgitation (TR) was significantly resolved after the surgery (P-value: 0.006). Of 17 (18.1%) patients with small or hypoplastic pulmonary artery (PA) branches, 14 patients had acceptable PA branch size after surgery. Conclusion TFTC at an older age is safe with acceptable results. Age is not a contraindication for TFTC and surgery should be recommended if the patients are diagnosed with TOF in adulthood. Also, the TOF diagnosis should be considered in adult patients with suspicious signs and symptoms.

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Section: Discussionmentioning

confidence: 97%

Short-term outcomes following total correction of tetralogy of fallot in adult patients

Khajali,

Mohammadi,

Toloueitabar

et al. 2023

J Cardiothorac Surg

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show abstract

“…Also, severe obstruction was not found in any of the patients after the surgery. The results of the previous surgery for TFTC in the patients who were older than the recommended age, was successful (24,25).…”

Section: Discussionmentioning

confidence: 97%

Short-Term Outcomes Following Total Correction of Tetralogy of Fallot in Adult Patients

Khajali

Mohammadi

Maleki

et al. 2023

Preprint

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Objectivs: Tetralogy of Fallot (TOF) is a common congenital heart disease which should be corrected. The recommended time for the Tetralogy of Fallot Total Correction (TFTC) surgery is during the infancy for the possible difficulties during the surgery and the related issues. However, sometimes TOF is diagnosed and managed during the adulthood. Methods This study is a descriptive and retrospective one which included all patients who underwent TFTC at age of 15-year and older in a 10 -year period (between the years 2010 and 2020) to identify short-term (including in-hospital mortality, ICU Length of stay, respiratory complications after the surgery such as: pulmonary edema, pneumonia and etc. and bleeding after the surgery) and one-year (including left ventricle ejection fraction (LVEF), right ventricle (RV) ejection fraction, severity of tricuspid regurgitation and aortic regurgitation after surgery) outcomes. All data were taken from medical records at Shahid Rajaei Hear Center. Data were analyzed using SPSS 22. Results 94 patients with the mean age of 26.7 ± 9.6 years were enrolled. Most of them were male (59.6%) (P-value: 0.009). In-hospital mortality in our study were 5.3%. Tricuspid regurgitation (TR) was significantly resolved after the surgery (P-value: 0.006). Also, the correction of pulmonary size after the surgery was significant (P-value: 0.000). Conclusion This study showed that the surgery at older age is safe and the results are acceptable. Aging is not a contraindication for TFTC and surgery should be recommended if the patients are diagnosed with TOF at adulthood. Also, screening TOF in adult patients should be considered.

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“…Patients who underwent surgery for Tetralogy of Fallot correction at an age beyond the recommended timeframe demonstrated favorable outcomes from their surgery, suggesting that the procedure remains efficacious even when conducted in later stages of life ( 22 , 23 ). While the optimal window for corrective surgery in Tetralogy of Fallot is conventionally recognized as being within the first year of life, it is important to acknowledge that patients may present at a later stage due to a variety of factors.…”

Section: Discussionmentioning

confidence: 99%

Midterm prognosis following total correction of tetralogy of fallot in adult patients

Khajali,

Mohammadi,

Toloueitabar

et al. 2023

Front. Cardiovasc. Med.

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BackgroundTetralogy of Fallot is a common congenital heart disease characterized by cyanosis. The primary treatment approach involves corrective surgery typically performed within the first year of life to achieve complete resolution. However, certain patients may undergo surgery at an older age. This study seeks to assess the efficacy of surgery by examining the midterm outcomes of total correction of Tetralogy of Fallot when performed in older individuals.MethodsThis interventional-longitudinal study focused on patients who underwent complete surgery to correct tetralogy of Fallot at an advanced age of over 15 years. All of the participants were referred to the Shahid Rajaei Heart and Vascular Center, which is a referral center for congenital heart diseases in Iran, between 2010 and 2020. The surgical procedures for these patients involved primary total correction of tetralogy of Fallot or surgery following by shunt implantation. Prior to the surgery, the necessary information was gathered from the patients' medical records. The patients were then monitored over a 5-year period, during which they received regular check-ups from cardiologist with fellowship in adult congenital heart disease.ResultsA total of 94 participants were enrolled in the study, with an average age of 26.7 ± 9.6 years. Notably, the majority of the participants were male. The study reported a late mortality rate of 3.2%. Furthermore, 17 patients, constituting 18% of the cohort, underwent a secondary surgical procedure. This secondary surgery encompassed 14 cases of Pulmonary Valve Replacement (14.8%) and 3 cases of Ventricular Septal Defect repair (3.1%).ConclusionWhile the optimal age for total correction of Tetralogy of Fallot is conventionally considered to be within the first year of life, this study demonstrated that surgical intervention performed at a later stage of life can yield favorable midterm prognoses. It is imperative to emphasize that individuals unable to undergo surgery at the ideal age due to a multitude of factors should not be deprived of the potential benefits associated with surgical intervention.

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Contemporary early results of late repair of tetralogy of Fallot in children: a single-centre case series

Cited by 4 publications

References 20 publications

Short-term outcomes following total correction of tetralogy of fallot in adult patients

Short-term outcomes following total correction of tetralogy of fallot in adult patients

Short-Term Outcomes Following Total Correction of Tetralogy of Fallot in Adult Patients

Midterm prognosis following total correction of tetralogy of fallot in adult patients

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