Contemporary Developments in Ferrocene Chemistry: Physical, Chemical, Biological and Industrial Aspects

Abstract

Ferrocenyl-based compounds have many applications in diverse scientific disciplines, including in polymer chemistry as redox dynamic polymers and dendrimers, in materials science as bioreceptors, and in pharmacology, biochemistry, electrochemistry, and nonlinear optics. Considering the horizon of ferrocene chemistry, we attempted to condense the neoteric advancements in the synthesis and applications of ferrocene derivatives reported in the literature from 2016 to date. This paper presents data on the progression of the synthesis of diverse classes of organic compounds having ferrocene scaffolds and recent developments in applications of ferrocene-based organometallic compounds, with a special focus on their biological, medicinal, bio-sensing, chemosensing, asymmetric catalysis, material, and industrial applications.

Kinetic Resolution of a Planar–Chiral [2.2]Paracyclophane via Michael Addition to Nitroolefins Catalyzed by N‐Terminal Guanidinylated Helical Peptide

“…Planarly chiral compounds constitute a unique and specialized category within chiral compounds [12] . They showcase unique structural features that confer chirality, presenting captivating properties and applications across diverse fields [13–15] . However, due to the lack of general methodology, the reported asymmetric synthesis have been limited in number [15–21] .…”

Recent Advances in the Field of Amino Acid-Conjugated Aminoferrocenes—A Personal Perspective

“…A considerable number of compounds derived from ferrocenes functionalized with reactive groups tethered to one or both cyclopentadienyl rings have been synthesized to date, and a comprehensive overview of their application in a variety of fields, including catalysis, materials science and sensing, and medicine, has recently been given [4][5][6][7][8]. In addition, our work on the conformational and biological evaluation of ferrocene conjugates with mannose, resveratrol, and natural amino acids was systematically reviewed [9].…”

Chlorido-pentamethylcyclopentadienyl-[2-(2-pyridyl-кN)-ferrocenyl-кC]-iridium(III)

“…One major result was that electrostatic repulsions determine the stereochemical outcome of these cycloiridation reactions. Another important group of organometallic compounds are donor-functionalised ferrocenes, which have been shown to have numerous applications mainly in the realms of catalysis and anticancer drug research [10][11][12][13][14]. Considering these overlapping applications, it seemed to be natural to combine these two research areas and study the heteronuclear Fe(II)-Ir(III) complexes involved [4,[15][16][17].…”