Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: An analytical review

Zhang, Lingyi; Wang, Guqi; Hou, Weihong; Li, Ping; Dulin, Andrea; Bonkovsky, Herbert L.

doi:10.1002/hep.23384

Cited by 105 publications

(90 citation statements)

References 11 publications

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“…An internet based review study in China found that, the most used herbal product was Mongolian milk vetch root. 8 In our study, majority of patients used only one product while some patients used multiple concurrently. A questionnaire of 310 patients applied by family physician recently in Ankara revealed that, 84.5% of patients were interested in herbal treatment and they used such treatment in the past.…”

Section: Discussionmentioning

confidence: 77%

Use of alternative product in patients with chronic viral hepatitis

Dülger¹,

Sünbül²,

Yılmaz

et al. 2014

Jmid

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Objectives: Some of the patients with chronic hepatitis use both alternative product and/or antiviral treatment. These herbal products sometimes lead to clinical deterioration. In this study we aimed to determine the purpose of alternative product utilization and rate among the chronic hepatitis B (CHB) and C (CHC) patients.Methods: This prospective cohort study included 200 consecutive adult patients with chronic hepatitis B and C at the Department of Infectious Diseases, Ondokuz Mayis University, between 1 March 2012 and 30 July 2012. At enrollment, clinical information, demographics, laboratory variables and knowledge about alternative products were recorded.Results: Of the patients 150 had CHB, 50 had CHC. 54% of patients were male. Use of alternative products was 26%. Antiviral treatment rate was 48.5% for all patients. The most used alternative products were artichoke extract and honey. 67.3% of patients were using single alternative product whereas the others were using two or more alternative products. 46.2% of patients who use alternative product provided information about the alternative product usage, but the others did not. Conclusions:Majority of patients used alternative products. More than half of these patients did not give information to their physicians about their use of alternative medicine. Use of alternative product should be asked in all patients with chronic hepatitis.Herbal product usage was detected in majority of patients and also approximately half of these patients did not give information to their doctors about taking alternative medicine. In conclusion, it is necessary to take detailed information about herbal product usage in patients with chronic hepatitis.

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Section: Discussionmentioning

confidence: 77%

Use of alternative product in patients with chronic viral hepatitis

Dülger¹,

Sünbül²,

Yılmaz

et al. 2014

Jmid

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“…Peginterferon achieved better effects than interferon did in the treatment of hepatitis B in previous studies [23]. Chinese herbs plus interferon have been associated with higher sustained virological response than interferon alone in chronic hepatitis C and B [12][13][14]24]. Chinese herbs have also been reported to improve the adverse effects of peginterferon or interferon in the treatment of chronic hepatitis [14,24].…”

Section: Discussionmentioning

confidence: 94%

“…As one of the main components of CAM, Chinese medicine has been used as a front-line medicine and has been widely utilized in medical systems, especially in China and some areas of Asia. Adverse reactions to Chinese herbs are rare and negligible when compared to those commonly produced by pharmaceutical drugs [9][10][11][12][13][14]. Interferon plus Chinese herbs is associated with higher sustained virological response than interferon alone in chronic hepatitis C and B [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Peginterferon and Chinese herbs exert a combinatorial effect in HBeAg-positive chronic hepatitis B

Gao

Cheng

et al. 2016

J Infect Dev Ctries

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Introduction: Traditional Chinese herbs are widely used for the treatment of chronic hepatitis B (CHB) in China. The aim of this study was to perform a meta-analysis of randomized controlled trials (RCTs) comparing peginterferon therapies with peginterferon plus Chinese herbal therapies in hepatitis B e antigen (HBeAg)-positive CHB patients. Methodology: The main biomedical databases were searched to identify RCTs that compared the efficiency of peginterferon with peginterferon plus Chinese herbs in CHB patients. Results: The literature search yielded 616 studies, and 8 RCTs (624 patients) matched the selection criteria. Combined therapies of peginterferon plus Chinese herbal therapies were superior to peginterferon therapies alone in achieving the serum HBV DNA clearance rate (64.5% vs. 45.0%), serum HBeAg clearance rate (47.4% vs. 33.5%), and HBeAg seroconversion rates (39.2% vs. 23.1%) at the end of treatment. Combined therapies were more effective than peginterferon alone therapies in the improvement of liver fibrosis related biomarkers, including hyaluronic acid, procollagen type III, type IV collagen, and lamina. Combined therapies also resulted in fewer relapses, fewer adverse events, and more rapid alanine transaminase normalization. Conclusions: The current evidence suggests that peginterferon plus Chinese herbal therapies were associated with higher virological response than peginterferon alone in HBeAg-positive CHB patients.

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“…With the development of TCM, CHB was named as stagnancy of liver-qi and blood or hot liver. A recent study showed that TCM had a greater beneficial effect (P ¼0.0003) than IFN and slightly better effect (P¼0.01) than LAM on normalization of serum ALT, and TCM had a similar beneficial effect when compared with IFN or LAM for CHB on antiviral activity as evidenced by the loss of serum HBeAg and HBV DNA (Zhang et al, 2010). TCM syndrome classification (also defined as Zheng differentiation) and treatment are the basis concept of TCM theory.…”

Section: Introductionmentioning

confidence: 96%