2021
DOI: 10.1021/acs.jnatprod.1c00625
|View full text |Cite
|
Sign up to set email alerts
|

Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

Abstract: The pressing need for SARS-CoV-2 controls has led to a reassessment of strategies to identify and develop natural product inhibitors of zoonotic, highly virulent, and rapidly emerging viruses. This review article addresses how contemporary approaches involving computational chemistry, natural product (NP) and protein databases, and mass spectrometry (MS) derived target–ligand interaction analysis can be utilized to expedite the interrogation of NP structures while minimizing the time and expense of extraction,… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
14
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
5

Relationship

3
2

Authors

Journals

citations
Cited by 7 publications
(14 citation statements)
references
References 68 publications
0
14
0
Order By: Relevance
“…This type of high throughput workflow allows for the rapid creation of natural, antiviral drug leads and could effectively lead to a broad-spectrum prophylactic/therapeutic for future betacoronavirus pathogens. 46 …”
Section: Introductionmentioning
confidence: 99%
“…This type of high throughput workflow allows for the rapid creation of natural, antiviral drug leads and could effectively lead to a broad-spectrum prophylactic/therapeutic for future betacoronavirus pathogens. 46 …”
Section: Introductionmentioning
confidence: 99%
“…Marine natural products remain a highly important source for emerging drugs, especially in the treatments of cancers and viral infections [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. One such potential drug is manzamine-A, a marine sponge derived alkaloid that emerged in the field of infectious disease as a promising control for malaria [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. The understanding of manzamine and derived analogs utility in medicine is nascent, but is proposed to include treatment for malaria [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ], herpes [ 29 , 36 , 37 , 38 ], HIV [ 29 , 32 , 39 , 40 , 41 , 42 , 43 , 44 ], cancer [ 6 , 10 , 13 , 35 , 37 , 38 , 39 , 44 , 45 ], as well as generally having anti-bacterial, antifungal, and anti-inflammatory activities [ 15 , 17 , 19...…”
Section: Introductionmentioning
confidence: 99%
“…The present approach drew upon the highly conserved nature of the SARS-CoV-2, SARS, and MERS S-adenosylmethionine (SAM) (1)-dependent 2′-O-MTase protein as the therapeutic target. 25,26 The 2′-O-MTase with EC no. 2.1.1.57 (https://www.brenda-enzymes.org/enzyme.php?ecno=2.1.1.…”
mentioning
confidence: 99%
“…8−10,33−36 Presented here is a continuation of previous work described in the viewpoint "Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses". 25 The intent of that earlier work was to describe strategies for efficiently identifying natural products using in silico molecular modeling techniques typically used in rational drug design with synthetic molecule libraries. 37 This effort was also intended to address production limitations commonly encountered in natural product screening where access to source material and the labor of isolating large sets of compounds can quickly outstrip an academic laboratory's research capacity.…”
mentioning
confidence: 99%
See 1 more Smart Citation