Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review

Dharmaratne, Priyanga; Sapugahawatte, Dulmini Nanayakkara; Wang, Baiyan; Chan, Chung Lap; Lau, Ken; Lau, Clara Bik‐San; Fung, Kwok Pui; Ng, Dennis K. P.; Ip, Margaret

doi:10.1016/j.ejmech.2020.112341

Cited by 75 publications

(46 citation statements)

References 167 publications

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“…When it comes to hydrogels for which antibacterial properties are light-sensitive, their mechanism of action falls in line with photodynamic therapy (PDT). On this topic, several most interesting reviews dealing with PDT, hydrogels and their use in medicine have been published [34,53]. Briefly, the antibacterial mechanism of action is based on the generation of reactive oxygen species (ROS) because of an energy transfer from a light-absorbing chromophore-based compound called photosensitizer (PS) in its excited triplet state to molecular oxygen (Figure 15) [34,53,63,86].…”

Section: Light-triggered Antibacterial Activity Of Hydrogelsmentioning

confidence: 99%

“…On this topic, several most interesting reviews dealing with PDT, hydrogels and their use in medicine have been published [34,53]. Briefly, the antibacterial mechanism of action is based on the generation of reactive oxygen species (ROS) because of an energy transfer from a light-absorbing chromophore-based compound called photosensitizer (PS) in its excited triplet state to molecular oxygen (Figure 15) [34,53,63,86]. The photosensitizer goes from its fundamental electronic singlet state to a short-lived excited singlet state ( 1 PS*) upon irradiation under an adequate wavelength.…”

Section: Light-triggered Antibacterial Activity Of Hydrogelsmentioning

confidence: 99%

“…For hydrogels for which antibacterial properties are based on the light-triggered generation of ROS or [ 1 O2], photosensitizers are usually included in the preparation mixture and embedded in the final 3D polymeric network, either by grafting them onto oligomeric Depending on the reactive species formed, two types of PDT can be distinguished [34,53,63,86]. Redox reactions between 3 PS* and substrates in the studied environment leading to the generation of radicals, which ultimately interact with molecular oxygen and other compounds in the environment to form oxygen, peroxide or hydroxide radicals, constitutes type I.…”

Section: Light-triggered Antibacterial Activity Of Hydrogelsmentioning

confidence: 99%

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Light and Hydrogels: A New Generation of Antimicrobial Materials

Pierau

Versace

2021

Materials

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Nosocomial diseases are becoming a scourge in hospitals worldwide, and new multidrug-resistant microorganisms are appearing at the forefront, significantly increasing the number of deaths. Innovative solutions must emerge to prevent the imminent health crisis risk, and antibacterial hydrogels are one of them. In addition to this, for the past ten years, photochemistry has become an appealing green process attracting continuous attention from scientists in the scope of sustainable development, as it exhibits many advantages over other methods used in polymer chemistry. Therefore, the combination of antimicrobial hydrogels and light has become a matter of course to design innovative antimicrobial materials. In the present review, we focus on the use of photochemistry to highlight two categories of hydrogels: (a) antibacterial hydrogels synthesized via a free-radical photochemical crosslinking process and (b) chemical hydrogels with light-triggered antibacterial properties. Numerous examples of these new types of hydrogels are described, and some notions of photochemistry are introduced.

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Section: Light-triggered Antibacterial Activity Of Hydrogelsmentioning

confidence: 99%

Section: Light-triggered Antibacterial Activity Of Hydrogelsmentioning

confidence: 99%

Section: Light-triggered Antibacterial Activity Of Hydrogelsmentioning

confidence: 99%

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Light and Hydrogels: A New Generation of Antimicrobial Materials

Pierau

Versace

2021

Materials

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“…Photodynamic therapy (PDT) is a versatile therapeutic technique that has been successfully applied throughout the years in cancer treatment [ 1 , 2 , 3 , 4 , 5 ], aged related macular degeneration [ 3 , 6 ] and in the inactivation of microorganisms (antimicrobial PDT = aPDT) under clinical and non-clinical contexts [ 7 , 8 , 9 , 10 ]. More recently, the possibility of exploring the approach for improving wound healing/tissue regeneration after a traumatic lesion is attracting the attention of several research groups [ 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing

Vallejo

Moura

Faustino

et al. 2020

IJMS

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The concept behind photodynamic therapy (PDT) is being successfully applied in different biomedical contexts such as cancer diseases, inactivation of microorganisms and, more recently, to improve wound healing and tissue regeneration. The effectiveness of PDT in skin treatments is associated with the role of reactive oxygen species (ROS) produced by a photosensitizer (PS), which acts as a “double agent”. The release of ROS must be high enough to prevent microbial growth and, simultaneously, to accelerate the immune system response by recruiting important regenerative agents to the wound site. The growing interest in this subject is reflected by the increasing number of studies concerning the optimization of relevant experimental parameters for wound healing via PDT, namely, light features, the structure and concentration of the PS, and the wound type and location. Considering the importance of developing PSs with suitable features for this emergent topic concerning skin wound healing, in this review, a special focus on the achievements attained for each PS class, namely, of the non-porphyrinoid type, is given.

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“…With a remarkably unique mode of action, antimicrobial photodynamic therapy (aPDT) has emerged as a promising alternative [7][8][9]. It utilizes the combined action of three nontoxic components, namely a photosensitizer (PS), light, and molecular oxygen to generate cytotoxic reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Monosubstituted tricationic Zn(II) phthalocyanine enhances antimicrobial photodynamic inactivation (aPDI) of methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxicity evaluation for topical applications: in vitro and in vivo study

Dharmaratne

Wang

Wong

et al. 2020

Emerging Microbes & Infections

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Antimicrobial photodynamic therapy (aPDT) is an innovative approach to combat multi-drug resistant bacteria. It is known that cationic Zn(II) phthalocyanines (ZnPc) are effective in mediating aPDT against methicillin-resistant Staphylococcus aureus (MRSA). Here we used ZnPc-based photosensitizer named ZnPcE previously reported by our research group to evaluate its aPDT efficacy against broad spectrum of clinically relevant MRSAs. Remarkably, in vitro anti-MRSA activity was achieved using near-infrared (NIR, >610 nm) light with minimal bactericidal concentrations ranging <0.019-0.156 µM against the panel of MRSAs. ZnPcE was not only significantly (p < .05) more potent than methylene blue, which is a clinically approved photosensitizer but also demonstrated low cytotoxicity against human fibroblasts cell line (Hs-27) and human immortalized keratinocytes cell line (HaCaT). The toxicity was further evaluated on human 3-D skin constructs and found ZnPcE did not manifest in vivo skin irritation at ≤7.8 µM concentration. In the murine MRSA wound model, ZnPcE with PDT group demonstrated > 4 log 10 CFU reduction and the value is significantly higher (p < .05) than all test groups except positive control. To conclude, results of present study provide a scientific basis for future clinical evaluation of ZnPcE-PDT on MRSA wound infection.

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Contemporary approaches and future perspectives of antibacterial photodynamic therapy (aPDT) against methicillin-resistant Staphylococcus aureus (MRSA): A systematic review

Cited by 75 publications

References 167 publications

Light and Hydrogels: A New Generation of Antimicrobial Materials

Light and Hydrogels: A New Generation of Antimicrobial Materials

An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing

Monosubstituted tricationic Zn(II) phthalocyanine enhances antimicrobial photodynamic inactivation (aPDI) of methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxicity evaluation for topical applications: in vitro and in vivo study

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