Contemporary adjuvant polymethyl methacrylate cementation optimally limits recurrence in primary giant cell tumor of bone patients compared to bone grafting: a systematic review and meta-analysis

Zuo, Dongqing; Zheng, Longpo; Sun, Wei; Fu, Dong; Hua, Yingqi; Cai, Zhengdong

doi:10.1186/1477-7819-11-156

Cited by 30 publications

(36 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Intralesional curettage + bone grafting alone has some controversies compared to curettage + cementing and also adding adjuvant therapies. In the systematic review of Zuo et al (22) published in 2013, local recurrence rate was higher in curettage + bone grafting than in curettage + cementing patients. Also, curettage + grafting + adjuvant treatment was found with a higher recurrence rate than curettage + cementing + adjuvant patients in the same systematic review.…”

Section: Discussionmentioning

confidence: 96%

Giant Cell Tumor of the Sacrum and Current Treatment Strategies

Öner¹,

Akman²

2020

jtss

View full text Add to dashboard Cite

Objective: Giant cell tumor (GCT) is a benign local aggressive tumor seen mostly in the third and fourth decades. Sacrum is the most commonly affected spinal region, followed by thoracic, cervical and lumbar regions. Aim of this study is to evaluate the results of surgical treatment in sacral GCT and review the treatment options of GCT in this uncommon location. Materials and Methods: Between 2002 and 2018, online hospital database search was conducted for a diagnosis of sacrum and GCT. Patient records were evaluated for recurrence and called for last follow-up. Results: There were four patients (one male, three female) operated due to sacral GCT, included in the study. Mean follow-up was 49 (25 to 82) months. High speed burr, electrocauterization and phenol were used as adjuvant treatment in all cases. Cementing was used in two patients. Conclusion: En bloc resection is the most effective treatment method with the lowest recurrence rate, yet it has the highest morbidity. In addition to intralesional curettage, high speed burr, electrocauterization, phenol and cement as adjuvant therapies can be used in the treatment of GCTs to decrease local recurrence in sacral cases while protecting neural tissues.

show abstract

Section: Discussionmentioning

confidence: 96%

Giant Cell Tumor of the Sacrum and Current Treatment Strategies

Öner¹,

Akman²

2020

jtss

View full text Add to dashboard Cite

show abstract

“…Traditionally, bone graft or bone cement is used in humans. 1,2,13,24 In the present case, and for several reasons, PMMA bone cement was chosen. The exothermic reaction, which occurs as the cement polymerizes, releases heat which may destroy any tumour cells remaining on the borders of the lesion after curettage and coblation, particularly under the tibial plateau where curettage was done with caution.…”

Section: Discussionmentioning

confidence: 99%

“…Local tumour recurrence was found to be minimal in human patients treated with PMMA cement as compared with bone grafting. 13,24 The long-term prognosis regarding joint function after subchondral bone replacement by cement remains unknown. Curettage may have a deleterious effect on articular cartilage when it is performed adjacent to a joint.…”

Section: Discussionmentioning

confidence: 99%

A Case of Giant Cell Tumour of Bone in a Dog

et al. 2019

View full text Add to dashboard Cite

Case Description A 9-year-old neutered female mixed-breed dog was presented for the assessment of right pelvic limb lameness of 1-week duration. The lameness had progressed to non-weight bearing the day before presentation. Diagnostic Findings Radiographic examination of the right stifle joint revealed a large purely lytic lesion affecting the proximal metaphysis and epiphysis of the right tibia associated with a pathological fracture of the tibial plateau. These findings, combined with histological evaluation of a bone biopsy performed under ultrasound-guidance, were suggestive of a giant cell tumour of bone. Treatment and Outcome A limb-sparing procedure was attempted as first-line treatment. Curettage of the tumour was followed by coblation, and the defect was filled with polymethyl methacrylate bone cement. Physical and radiographic follow-up examinations 1, 2 and 3 months after surgery revealed improved functional outcome and minor progression of osteolysis. However, local recurrence was apparent 5 months after initial surgery and the limb was therefore amputated. Clinical Relevance Giant cell tumour of bone is rare in dogs. In humans, the traditional surgical management is curettage. This treatment was attempted here for the first time in a dog and the short-term outcome was satisfactory. However, in this particular case, local control of the tumour was unsuccessful.

show abstract

“…A pesar de ello, hay estudios que muestran una alta recurrencia en TCGO grado iii 7 . La resección en bloque y reconstrucción posterior de aquellos TCGO cerca de las articulaciones se ha descrito como tratamiento de elección debido a su menor tasa de recurrencia local frente al legrado 3,8 , mientras que otros autores promulgan que esta opción no es correcta para la mayoría de los casos 7,9 . Creemos que esta opción es muy agresiva, más aún teniendo en cuenta la juventud de los pacientes de la serie, decantándonos por la resección en bloque y la reconstrucción en aquellos casos de TCGO grado iii de Campanacci 3 con importante destrucción cortical.…”

Section: Discussionunclassified