Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields
Leili Baghaie,
Fleur Leroy,
Mehdi Sheikhi
et al.
Abstract:Mutations and the glycosylation of epitopes can convert immunogenic epitopes into non-immunogenic ones via natural selection or evolutionary pressure, thereby decreasing their sensitivity to neutralizing antibodies. Based on Thomas Francis’s theory, memory B and T cells induced during primary infections or vaccination will freeze the new mutated epitopes specific to naïve B and T cells from the repertoire. On this basis, some researchers argue that the current vaccines derived from the previous strains of the … Show more
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