Contemporaneous reproduction of preclinical science: a case study of FSH and fat

Rosen, Clifford J.; Zaidi, Mone

doi:10.1111/nyas.13457

Cited by 12 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recent studies have shown that FSH is a primary regulator of body fat and energy homeostasis (Liu et al 2015(Liu et al , 2017. Notably, we found increases in bone mass and lowered body fat in mice treated with an anti-FSH antibody, as well as in mice genetically deficient in FSH or the FSHR (Sun et al 2006, Liu et al 2017, Rosen & Zaidi 2017, Ji et al 2018. A further interesting observation was the induction of thermogenic 'beige' adipose tissue and, as a consequence, increased energy expenditure in antibody-treated mice (Liu et al 2017).…”

Section: Introductionsupporting

confidence: 49%

“…These murine models include mature male and female mice fed pairwise or ad libitum on a high-fat diet or on normal chow, sham-operated and ovariectomized mice, 8-month-old mice, and Fshr +/− mice (Liu et al 2017). The data have been replicated and reproduced at multiple laboratories using multiple modalities, namely quantitative nuclear magnetic resonance (qNMR), dualenergy X-ray absorptiometry (DXA), μ-CT, and manual weighing of tissues (Liu et al 2017, Rosen & Zaidi 2017. Equally impressive declines were noted in subcutaneous, visceral, perigonadal, inguinal and bone marrow fat compartments (Liu et al 2017).…”

Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

See 1 more Smart Citation

FSH-metabolic circuitry and menopause

Taneja

Gera

Kim

et al. 2019

Journal of Molecular Endocrinology

Self Cite

View full text Add to dashboard Cite

FSH has a primary function in procreation, wherein it induces estrogen production in females and regulates spermatogenesis in males. However, in line with our discoveries over the past decade of non-unitary functions of pituitary hormones, we and others have described hitherto uncharacterized functions of FSH. Through high-affinity receptors, some of which are variants of the ovarian FSH receptor (FSHR), FSH regulates bone mass, adipose tissue function, energy metabolism, and cholesterol production in both sexes. These newly described actions of FSH may indeed be relevant to the pathogenesis of bone loss, dysregulated energy homeostasis, and disordered lipid metabolism that accompany the menopause in females and aging in both genders. We are therefore excited about the possibility of modulating circulating FSH levels toward a therapeutic benefit for a host of age-associated diseases, including osteoporosis, obesity and dyslipidemia, among other future possibilities.

show abstract

Section: Introductionsupporting

confidence: 49%

Section: Journal Of Molecular Endocrinologymentioning

confidence: 99%

FSH-metabolic circuitry and menopause

Taneja

Gera

Kim

et al. 2019

Journal of Molecular Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, anti-FSHβ antibody failed to decrease adiposity in Fshr +/− male mice fed on a high-fat diet, proving FSH specificity (9). These observations were reproduced contemporaneously in other centers, using various laboratory methods (9, 100).…”

Section: Introductionmentioning

confidence: 81%

FSH Beyond Fertility

et al. 2019

Self Cite

View full text Add to dashboard Cite

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

show abstract

“…We term this "contemporaneous replication"-a level of rigor that, we believe, contributed to our recent NIH U19 funding. 11,55 As noted above, there is clear evidence that osteoporosis and obesity track together at menopause. Furthermore, there is an evolving consensus that obesity itself may predispose to bone loss.…”

Section: Transdisciplinary Efforts Lead To the Discovery Of Fsh Actmentioning

confidence: 91%

“…In doing so, key data sets were replicated in Dr Rosen's lab using either the same or different technologies. 11,55 We each found that following ovariectomy or after being fed with a high-fat diet, mice receiving the anti-FSH antibody lost body fat, and that this was independent of food intake that was somewhat increased. 11 Both our groups used DXA, quantitative NMR, and direct weight measurements to document these effects in both male and female mice of different ages.…”

Section: Transdisciplinary Efforts Lead To the Discovery Of Fsh Actmentioning

confidence: 97%

Beyond bone biology: Lessons from team science

Zaidi

Lizneva

Gera

et al. 2020

Journal Orthopaedic Research

Self Cite

View full text Add to dashboard Cite

Today, research in biomedicine often requires the knowledge and technologies in diverse fields. Therefore, there is an increasing need for collaborative team science that crosses traditional disciplines. Here, we discuss our own lessons from both interdisciplinary and transdisciplinary teams, which ultimately ushered us to expand our research realm beyond bone biology. K E Y W O R D S biomarkers, bone, cell and molecular imaging, metabolic bone disease, osteoporosis 1 | INTRODUCTION The cataloging of human mutations, the use of mouse genetics to recapitulate human disease, and the rapid evolution of methods in computational biology, including the ability to study the genome, transcriptome, and cistrome, now at the single-cell resolution, have together had a major impact on how basic biological research is translated into bedside medicine. Such has happened in bone biology

show abstract

Contemporaneous reproduction of preclinical science: a case study of FSH and fat

Cited by 12 publications

References 15 publications

FSH-metabolic circuitry and menopause

FSH-metabolic circuitry and menopause

FSH Beyond Fertility

Beyond bone biology: Lessons from team science

Contact Info

Product

Resources

About