Contamination of intravenous infusion systems—the effect of changing administration sets

Jakobsen, Carl-Johan; Grabe, N.; Nielsen, Eddie; Højbjerg, Tove; Damm, M. D.; Lorentzen, Karsten; Ersgaard, H.V.; Villadsen, Jess; Heebøl-Holm, Bodil; Madsen, Jens Ivan; Jespersen, Bente; Lenler-Petersen, P; Sørensen, Carsten Åby; Jørgensen, Anders F.; Hvid, H. M.

doi:10.1016/0195-6701(86)90116-7

Cited by 16 publications

(11 citation statements)

References 11 publications

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“…Data from the study by Jakobsen et al, 8 which were given for five administration set change frequencies (ie, 24, 48, 72, 96, and 120 hours), were pooled appropriately for each analysis. Therefore, for the 24 hours versus 48 hours or more comparison, the 24-hour group data from this study were compared with the pooled results for the 48-, 72-, 96-, and 120-hour groups.…”

Section: Data Collection and Analysismentioning

confidence: 99%

“…There were no significant differences in the incidence of catheter colonization when the frequency of administration set changes was decreased from 24 hours to an interval of 48 hours or more, from 48 hours to an interval of 72 hours or more, or from 72 hours to an interval of 96 hours or more (Table 5). One study 8 reported the incidence of catheter colonization when the frequency of administration set changes was decreased from 24 hours to an interval of 48 hours or more. Two studies compared the incidence of catheter colonization when the frequency of administration set changes was decreased from 48 hours to 72 hours or more 8,9 and from 72 hours to 96 hours or more.…”

Section: Overall Findingsmentioning

confidence: 99%

“…One study 8 reported the incidence of catheter colonization when the frequency of administration set changes was decreased from 24 hours to an interval of 48 hours or more. Two studies compared the incidence of catheter colonization when the frequency of administration set changes was decreased from 48 hours to 72 hours or more 8,9 and from 72 hours to 96 hours or more. 8…”

Section: Overall Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Timing of Intravenous Administration Set Changes: A Systematic Review

Gillies

O'riordan

Wallen

et al. 2004

Infect. Control Hosp. Epidemiol.

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Section: Data Collection and Analysismentioning

confidence: 99%

Section: Overall Findingsmentioning

confidence: 99%

Section: Overall Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Timing of Intravenous Administration Set Changes: A Systematic Review

Gillies

O'riordan

Wallen

et al. 2004

Infect. Control Hosp. Epidemiol.

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“…B. 0,9% NaCl-Lösung, Ringer-Laktat-Lösung) zeigt sich bei 72-stündigem Wechsel der Infusionssysteme keine signifikant höhere bakterielle Kontamination als bei 48-stündigem [187,189,190] oder 24-stündigem Wechsel [191]. Dies gilt auch für Infusionen, die mittels Infusomaten verabreicht werden [192].…”

Section: Wechsel Von Infusionssystemenunclassified

Prävention Gefäßkatheterassoziierter Infektionen

Available¹

2002

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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“… 12 An unpublished conference abstract reported another RCT of 769 patients with AS replaced at 72 or 120 h, with no between-group differences in catheter colonisation or VAD-BSI. 13 Jakobsen et al 14 undertook a five-group RCT with AS changed at 24, 48, 72, 96 or 120 h and found no difference in catheter colonisation. Luskin et al 15 randomised 112 patients to have AS changes at 48, or 96 h to 192 h and reported no difference in infusate colonisation, infusate-related BSI or device colonisation.…”

Section: Introductionmentioning

confidence: 99%

Intravascular device administration sets: replacement after standard versus prolonged use in hospitalised patients—a study protocol for a randomised controlled trial (The RSVP Trial)

et al. 2015

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IntroductionVascular access devices (VADs), such as peripheral or central venous catheters, are vital across all medical and surgical specialties. To allow therapy or haemodynamic monitoring, VADs frequently require administration sets (AS) composed of infusion tubing, fluid containers, pressure-monitoring transducers and/or burettes. While VADs are replaced only when necessary, AS are routinely replaced every 3–4 days in the belief that this reduces infectious complications. Strong evidence supports AS use up to 4 days, but there is less evidence for AS use beyond 4 days. AS replacement twice weekly increases hospital costs and workload.Methods and analysisThis is a pragmatic, multicentre, randomised controlled trial (RCT) of equivalence design comparing AS replacement at 4 (control) versus 7 (experimental) days. Randomisation is stratified by site and device, centrally allocated and concealed until enrolment. 6554 adult/paediatric patients with a central venous catheter, peripherally inserted central catheter or peripheral arterial catheter will be enrolled over 4 years. The primary outcome is VAD-related bloodstream infection (BSI) and secondary outcomes are VAD colonisation, AS colonisation, all-cause BSI, all-cause mortality, number of AS per patient, VAD time in situ and costs. Relative incidence rates of VAD-BSI per 100 devices and hazard rates per 1000 device days (95% CIs) will summarise the impact of 7-day relative to 4-day AS use and test equivalence. Kaplan-Meier survival curves (with log rank Mantel-Cox test) will compare VAD-BSI over time. Appropriate parametric or non-parametric techniques will be used to compare secondary end points. p Values of <0.05 will be considered significant.Ethics and disseminationRelevant ethical approvals have been received. CONSORT Statement recommendations will be used to guide preparation of any publication. Results will be presented at relevant conferences and sent to the major organisations with clinical practice guidelines for VAD care.Trial registration numberAustralian New Zealand Clinical Trial Registry (ACTRN 12610000505000).

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Contamination of intravenous infusion systems—the effect of changing administration sets

Cited by 16 publications

References 11 publications

Timing of Intravenous Administration Set Changes: A Systematic Review

Timing of Intravenous Administration Set Changes: A Systematic Review

Prävention Gefäßkatheterassoziierter Infektionen

Intravascular device administration sets: replacement after standard versus prolonged use in hospitalised patients—a study protocol for a randomised controlled trial (The RSVP Trial)

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