Contamination of headwater streams in the United Kingdom by oestrogenic hormones from livestock farms

Matthiessen, Peter; Arnold, David W.; Johnson, Andrew C.; Pepper, T. J.; Pottinger, T.G.; Pulman, Kim G.T.

doi:10.1016/j.scitotenv.2006.02.007

Cited by 165 publications

(100 citation statements)

References 32 publications

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“…They are excreted by humans and livestock and discharged in the environment with effluents of sewage treatment plants (Kolpin et al 2002;Legler et al 2002;Snyder et al 2003) or with agricultural run off (Lange et al 2002;Johnson et al 2006;Matthiessen et al 2006). Only at certain specific locations, estrogenic activities were partly or fully caused by high concentrations of alkylphenols (Sheahan et al 2002;Fenet et al 2003;Cespedes et al 2004;Quiros et al 2005).…”

Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe

Houtman

2010

Journal of Integrative Environmental Sciences

196

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An increasing part of drinking water in Europe is prepared from surface water. At the same time, a growing number of emerging contaminants is being discovered in surface water. This review provides an overview of classes of emerging contaminants nowadays detected in the aquatic environment that are of relevance for drinking water production. These comprise e.g. endocrine disrupting compounds, such as hormones and compounds with hormone-like properties, pharmaceuticals, illicit and non-controlled drugs, sweeteners, personal care products, complexing agents, nanoparticles, perfluorinated compounds, flame retardants, pesticides, and fuel additives. The individual compounds are observed in concentrations that are generally considered too low to cause acute effects. Nevertheless, health effects due to long-term exposure to a mixture of low concentrations of all kinds of emerging contaminants cannot be excluded with current knowledge. Moreover, contamination of drinking water with man-made substances is considered unwanted in principle. The precautionary principle is used to motivate that prevention of emission of emerging contaminants into the environment is the preferred approach to safeguard sustainable drinking water production. In the mean time, extensive monitoring of the sources and development and application of advanced treatment techniques are used to prepare safe drinking water.

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Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe

Houtman

2010

Journal of Integrative Environmental Sciences

196

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“…To detect and identify the substances responsible for the observed estrogenic activities in environmental samples and trace their sources, the bioassay combined with gas (or liquid) chromatography-mass spectrometry was proved to be an effectively method (GS-MS or LC-MS) (Reineke et al, 2002;Matthiessen et al, 2006;Jonkers et al, 2010). Of the bioassays, in vivo experiments for investigating estrogenic effects are usually expensive and time-consuming, while in vitro bioassays are relatively rapid, inexpensive, and easy to perform to give first evidence of the occurrence of the total estrogenic contaminants in environmental samples (Campbell et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Determination of estrogens and estrogenic activities in water from three rivers in Tianjin, China

Rao

Lei

et al. 2013

Journal of Environmental Sciences

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Studies on estrogenic disrupting compounds (EDCs) occurrence and identification of main responsible compounds in river water discharged into the sea are of significance. In the present research, we screened estrogenic activities of 10 river water samples from 3 main rivers discharged into Bohai Sea in Tianjin using a recombinant two-hybrid yeast assay and chemical analysis by gas chromatography-mass spectrometry. All sample extracts induced significant estrogenic activity, with 17β-estradiol equivalents (EEQ) of raw water ranging from 5.72 to 59.06 ng/L. Six most concerned EDCs in the river water samples including estrone, 17β-estradiol, 17α-ethinylestradiol, estriol, diethylstilbestrol and estradiol valerate were determined, with their concentrations up to 50.70, 31.40, 24.40, 37.20, 2.56, and 8.47 ng/L, respectively. Through causality analysis by comparing the EEQ values of yeast assay and chemical analysis, 17α-ethinylestradiol and 17β-estradiol were identified as the main contributors to the estrogenic effects of the river samples, accounting for the whole estrogenic activities (62.99% to 185.66%), and estrogen antagonistic compounds might presented in the heavy polluted water samples. The proposed approach using both chemical analysis and bioassay could be used for identification and evaluation of the estrogenic activity of EDCs in river water.

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“…aneuploidy ͉ EE2 ͉ xenoestrogens E ndocrine disrupting chemicals are found ubiquitously worldwide due to human environmental contamination (1)(2)(3)(4). These chemicals comprise several different classes and those with an estrogenic mode of action (i.e., environmental estrogens) are of major concern.…”

mentioning

confidence: 99%

Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17α-ethynylestradiol

Brown

Schultz

Cloud

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Environmental contaminants that mimic native estrogens (i.e., environmental estrogens) are known to significantly impact a wide range of vertebrate species and have been implicated as a source for increasing human male reproductive deficiencies and diseases. Despite the widespread occurrence of environmental estrogens and recognized detrimental effects on male vertebrate reproduction, no specific mechanism has been determined indicating how reduced fertility and/or fecundity is achieved. Previous studies show that male rainbow trout, Oncorhynchus mykiss, exposed to the environmental estrogen 17␣-ethynylestradiol (EE2) before gamete formation and fertilization produce progeny with significantly reduced embryonic survival. To determine whether this observed decrease results from sperm chromosome alterations during spermatogenesis, male rainbow trout were exposed to 10 ng of EE2/l for 50 days. After exposure, semen was collected and sperm aneuploidy levels analyzed with two chromosome markers by fluorescent in situ hybridization. In vitro fertilizations were also conducted by using control and exposed sperm crossed to eggs from an unexposed female for offspring analysis. Evaluations for nucleolar organizer region number and karyotype were performed on developing embryos to determine whether sperm aneuploidy translated into embryonic aneuploidy. Results conclusively show increased aneuploid sperm formation due to EE2 exposure. Additionally, embryonic cells from propagated progeny of individuals possessing elevated sperm aneuploidy display high levels of embryonic aneuploidy. This study concludes that EE2 exposure in sexually developing male rainbow trout increases levels of aneuploid sperm, providing a mechanism for decreased embryonic survival and ultimately diminished reproductive success in EE2 exposed males.aneuploidy ͉ EE2 ͉ xenoestrogens

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Contamination of headwater streams in the United Kingdom by oestrogenic hormones from livestock farms

Cited by 165 publications

References 32 publications

Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe

Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe

Determination of estrogens and estrogenic activities in water from three rivers in Tianjin, China

Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17α-ethynylestradiol

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