Contamination of glioblastoma multiforme with type 1 herpes simplex virus

Postoperative Herpes Simplex Virus Encephalitis after Neurosurgery: Case Report and Review of the Literature

“…Even with adequate treatment, this infection is associated with a mortality rate of 19%-30% and important neurological aftereffects among survivors [1]. The occurrence of HSV encephalitis after neurosurgery is rare (table 1) [2][3][4][5][6][7]. All but 2 cases reported in the medical literature had an unfavorable outcome.…”

Herpes Simplex Encephalitis after Neurosurgical Operations: Report of 2 Cases and Review of the Literature

“…Except for one case with full recovery, the patients died or suffered from severe neurological deficits. 2,4,8,12,13,18,19 The most remarkable aspect is, that except for one case, surgery took place either in the frontotemporal area or the pituitary, near the sensory Gasserian ganglion. Therefore a relationship between this localization with consecutive involvement of the trigeminal ganglion should be considered.…”

Defining nervous system susceptibility during acute and latent herpes simplex virus-1 infection

“…An additional report recognized HSE symptoms and seizure development following neurosurgectomy of a parasagittal meningioma that resulted in death (Spuler et al, 1999). In a somewhat unique case, HSV-1 antigen was detected in cells of a glioblastoma removed from a 28-year old patient who later died 3 days following the surgery (Sheleg et al, 2001). Whether HSV-1 was acquired or reactivated during the development of the malignancy and may have contributed to the neuropathology associated with the neoplasia is unknown.…”