Contamination of Corneal Tissue From Infected Donors

Chittum, Mark E.; Grutzmacher, Richard D.; Oiland, Donna; Kalina, Robert E.

doi:10.1001/archopht.1985.01050060062026

Cited by 17 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Like sepsis, other donor conditions may affect the incidence of microbial colonization or contamination of the ocular surface and cornea. 7,9,16,17 This study examined the medical status of corneal donors before donation. We found that hospitalization or malignant neoplasm at the time of death more than doubled the odds of infection after keratoplasty.…”

Section: Commentmentioning

confidence: 99%

“…5,6 Judicious donor screening and good tissue practices aim to avert infections associated with transplant. Preventive strategies include deferral of donors with septicemia or endocarditis, [7][8][9] antiseptic preparation and aseptic retrieval of donor tissue, [9][10][11] and anti-infective preservation. 12,13 Microbiological assessment may also be done before distribution 14 or at keratoplasty.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Infectious Disease Risk Factors of Corneal Graft Donors

Hassan

Wilhelmus²,

Dahl³

et al. 2008

Arch Ophthalmol

View full text Add to dashboard Cite

To determine how donor health status affects the risk of infection after corneal transplant.Methods: An adverse reaction surveillance registry was used to conduct a matched case-control study among transplanted donor corneas from January 1, 1994, to December 31, 2003. Cases comprised 162 reports of endophthalmitis after penetrating keratoplasty including 121 with microbial recovery, of which 59 had concordant donor and recipient microbial isolates. Two controls were matched to each case by surgery date. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals according to the premortem status of decedent donors.Results: Postkeratoplasty endophthalmitis was associated with recent hospitalization (odds ratio, 2.84; 95% confidence interval, 1.61-4.98) and fatal cancer (odds ra-

show abstract

Section: Commentmentioning

confidence: 99%

mentioning

confidence: 99%

Infectious Disease Risk Factors of Corneal Graft Donors

Hassan

Wilhelmus²,

Dahl³

et al. 2008

Arch Ophthalmol

View full text Add to dashboard Cite

show abstract

“… 10 Early MK is usually due to ocular surface problems in the recipient, contamination of the donor cornea, and intraoperative contamination, whereas later MK is believed to be due to environmental pathogens. 9 , 15 , 16 , 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

Distribution of Microbial Keratitis After Penetrating Keratoplasty According to Early and Late Postoperative Periods

Özalp

Atalay

Köktaş³

et al. 2020

tjo

View full text Add to dashboard Cite

Objectives: The aim of this study was to investigate the distribution of microbial agents in the early and late postoperative periods in patients with microbial keratitis (MK) after penetrating keratoplasty (PK). Materials and Methods: The records of 36 patients who were clinically diagnosed as having MK after PK were retrospectively reviewed. Culture results were obtained from microbiology records and the organisms that were produced were noted. A case was deemed as viral keratitis based on the clinical appearance, negative cultures, and response to antiviral treatment. Keratitis development times were evaluated in 2 categories: early (within the first year) and late (after year 1) postoperative period. Mann-Whitney U and Kruskal-Wallis tests were used to compare numerical variables that did not show normal distribution and chi-square test was used to compare categorical variables. Results: The majority of MK cases were of bacterial origin (55.5%, n=20), followed by viral (41.7%, n=15) and fungal (2.8%, n=1). Of the 15 cases of early postoperative MK, 10 were bacterial, 4 were viral, and 1 was fungal; however, among cases of late postoperative MK, 10 were bacterial and 11 were viral. The majority (65%) of early and late bacterial infections were caused by gram-positive strains (most commonly staphylococci). Gram-positive bacteria caused keratitis significantly earlier than gram-negative bacteria (p=0.037). Viral and gram-negative bacterial MK was more frequent in the late postoperative period, but the difference was not statistically significant. Conclusion: In our study, bacterial keratitis was more common in post-keratoplasty MK than viral and fungal keratitis. Gram-positive bacteria were the most common causative agents. The increased incidence of gram-negative bacterial agents and viral keratitis in the late postoperative period can be explained by long-term topical steroid use.

show abstract

“…Fungal colonization of corneal transplants appears to be a combination of both donor-derived infection and contamination during organ harvesting and storage [49]. In studies evaluating both bacterial and fungal endophthalmitis after keratoplasty, factors associated with a higher incidence of positive donor corneal rim cultures include a history of mechanical ventilation, systemic infection in the donor, death in the hospital, and history of cancer [50][51][52].…”

Section: Candidiasismentioning

confidence: 39%

Donor-Derived Fungal Infections in Transplant Patients

Roy

Park

Chiller

2010

Curr Fungal Infect Rep

View full text Add to dashboard Cite

Fungal infection can occur in transplant patients via one of four mechanisms: donor-derived infections, contamination during the transplantation period, reactivation of latent infection in the host, or new infection during the posttransplantation period. Distinguishing between these mechanisms is often difficult and as a result, donorderived fungal infections may be under-recognized with few data on its prevalence. We review published reports of donor-derived fungal infections and discuss the role of donor screening and the importance of establishing a national reporting, tracking, and notification system for transplant-transmitted infections.

show abstract

Contamination of Corneal Tissue From Infected Donors

Cited by 17 publications

References 9 publications

Infectious Disease Risk Factors of Corneal Graft Donors

Infectious Disease Risk Factors of Corneal Graft Donors

Distribution of Microbial Keratitis After Penetrating Keratoplasty According to Early and Late Postoperative Periods

Donor-Derived Fungal Infections in Transplant Patients

Contact Info

Product

Resources

About